A5075408170- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- NF-κB Signaling Pathways
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Cellular transport and secretion
- RNA regulation and disease
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Retinal Development and Disorders
- Plant Pathogenic Bacteria Studies
- Plant-Microbe Interactions and Immunity
- Gut microbiota and health
Helmholtz Zentrum München
2021-2023
Target (United States)
2023
University of California, Berkeley
2018
Abstract Understanding the mechanisms of coronavirus disease 2019 (COVID-19) severity to efficiently design therapies for emerging virus variants remains an urgent challenge ongoing pandemic. Infection and immune reactions are mediated by direct contacts between viral molecules host proteome, vast majority these virus–host (the ‘contactome’) have not been identified. Here, we present a systematic contactome map severe acute respiratory syndrome 2 (SARS-CoV-2) with human encompassing more...
Balanced control of T cell signaling is critical for adaptive immunity and protection from autoimmunity. By combining genetically engineered mouse models, biochemical analyses pharmacological interventions, we describe an unexpected dual role the tumor necrosis factor receptor–associated 6 (TRAF6) E3 ligase as both a positive negative regulator mucosa-associated lymphoid tissue 1 (MALT1) paracaspase. Although MALT1-TRAF6 recruitment indispensable nuclear κB in activated cells, TRAF6...
Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune response and hyperinflammation. Aberrant expression cytokines chemokines is associated strong activation the immunoregulatory transcription factor NF-κB, which can be directly induced by protein NSP14. Here, we use NSP14 mutants generated cells host knockouts (KOs) in NF-κB signaling pathways to characterize molecular mechanism NSP14-induced activation. We demonstrate that full-length...
CARD11 acts as a gatekeeper for adaptive immune responses after T cell or B antigen receptor (TCR/BCR) ligation on lymphocytes. PKCθ/β-catalyzed phosphorylation of promotes the assembly CARD11-BCL10-MALT1 (CBM) complex and lymphocyte activation. Here, we demonstrated that PKCθ/β-dependent also suppressed functions in cells. Through mass spectrometry–based proteomics analysis, identified multiple constitutive inducible sites We single TCR- BCR-inducible Ser 893 carboxyl terminus prevented...
SUMMARY The molecular mechanisms by which the gut microbiome influences human health remain largely unknown. Pseudomonadota is third most abundant phylum in normal microbiomes. Several pathogens this can inject so-called virulence effector proteins into host cells. We report identification of intact type 3 secretion systems (T3SS) 5 - 20% commensal To understand their functions, we experimentally generated a high-quality protein-protein meta-interactome map consisting 1,263 interactions...