A5062403122- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrohydrodynamics and Fluid Dynamics
- Extracellular vesicles in disease
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Additive Manufacturing and 3D Printing Technologies
- Cellular Mechanics and Interactions
- Immune cells in cancer
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Periodontal Regeneration and Treatments
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Collagen: Extraction and Characterization
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Hemostasis and retained surgical items
University of the Basque Country
2015-2025
Instituto de Salud Carlos III
2020-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2015-2025
Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, recognition immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores process, highlighting engagement system, delving into behaviors innate adaptive cells chronic scenarios....
In the current study, we developed a novel gelatin-based bilayer wound dressing. We used different crosslinking agents to confer unique properties each layer, obtaining bioinspired multifunctional hydrofilm suitable for healing. First, produced resistant and non-degradable upper layer by lactose-mediated of gelatin, which provided mechanical support protection overall design. For lower crosslinked gelatin with citric acid, resulting in porous matrix great swelling ability. addition,...
Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory pro-regenerative properties that are beneficial for the treatment of chronic wounds. Thanks different mediators, MSC-EVs shown play an important role in proliferation, migration cell survival skin populations. However, there is still a big bid achieve most effective, suitable available source MSC-EVs.We isolated, characterized compared medium-large EVs (m-lEVs) small...
The formulation of hydrogels that meet the necessary flow characteristics for their extrusion-based 3D printing while providing good printability, resolution, accuracy and stability, requires long development processes. This work presents technological a hydrogel-based ink Laponite alginate evaluates its capacity. As novelty, this article reports standardizable protocol to quantitatively define best parameters novel inks, new printability evaluation such as Printing Accuracy Escalation...
Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based...
In the present study we developed an injectable, bioactive and degradable hydrogel composed of alginate at 2.5% oxidation degree calcium-activated platelet rich plasma (PRP) for wound healing applications (PRP-HG-2.5%). The gives mechanical support to while activated PRP provides growth factors that enhance fibrin which creates adequate microenvironment cell migration proliferation. rheological properties were characterized. Further characterization revealed PRP-HG-2.5% showed a faster...
Melanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling increase. However, traditional treatments lack effectiveness in advanced or metastatic patients. Immunotherapy, meanwhile, shown to be effective treatment option, but rate responding remains far from ideal. Here we have developed a personalized neoantigen peptide-based cancer vaccine by encapsulating patient derived melanoma neoantigens polyethylenimine (PEI)-functionalised...