A5072429105- Research on Leishmaniasis Studies
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Toxin Mechanisms and Immunotoxins
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Acne and Rosacea Treatments and Effects
- Insect and Pesticide Research
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Lipid Membrane Structure and Behavior
- Antioxidant Activity and Oxidative Stress
- Agricultural and Food Sciences
- Insect Pest Control Strategies
- Fatty Acid Research and Health
- Nail Diseases and Treatments
- Phytochemistry Medicinal Plant Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Diabetic Foot Ulcer Assessment and Management
- Natural product bioactivities and synthesis
- Garlic and Onion Studies
- Metabolomics and Mass Spectrometry Studies
Universidade Federal do Rio de Janeiro
2025
Universidade Federal de Minas Gerais
2015-2024
Universidade Federal do Tocantins
2024
Plan International
2024
Centro Hospitalar do Porto
2018-2023
GTx (United States)
2020
Universidade Estadual de Campinas (UNICAMP)
2017
MCPHS University
2012
University of Minho
2011
Hospital de Santo António
2004-2006
This work aims to investigate the influence of formation ion pairing between all-trans retinoic acid (RA) and a lipophilic amine (stearylamine; STE) on drug encapsulation efficiency (EE) stability solid lipid nanoparticles (SLNs). The SLNs were characterized for EE size. particle size significantly improved reduced, respectively, when surfactant or co-surfactant concentration increased. However, while formulation without STE allowed only 13% RA encapsulation, RA-STE-loaded was 94%. studies...
This work aimed to develop solid lipid nanoparticles (SLN) co-loaded with doxorubicin and α-tocopherol succinate (TS) evaluate its potential overcome drug resistance increase antitumoral effect in MCF-7/Adr NCI/Adr cancer cell lines. The SLN were prepared by a hot homogenization method characterized for size, zeta potential, entrapment efficiency (EE), loading (DL). cytotoxicity of or penetration was evaluated NCI/adr as monolayer spheroid model. showed size the range 74-80nm, negative EE...
Doxorubicin (DOX) is widely used in cancer treatment, however, its use often limited due to side effects. To avoid these shortcomings, the encapsulation of DOX into nanocarriers has been suggested. Herein, we proposed a novel nanostructured lipid carrier (NLC) formulation loading DOX, docosahexaenoic acid (DHA), and α-tocopherol succinate (TS) for treatment. DHA an omega-3 fatty TS vitamin E derivative. It that compounds can enhance antitumor activity chemotherapeutics. Thus, hypothesized...
Lapachol (LAP) is a natural compound with various biological properties, including anticancer activity. However, its clinical application limited due to the low aqueous solubility and potential adverse side effects. Nanoemulsions are drug delivery systems that can assist in administration of hydrophobic drugs, increasing their bioavailability protecting from degradation. Thus, this study aimed prepare LAP-loaded nanoemulsion (NE-LAP), evaluate antitumor For purpose, was prepared using hot...
Cancer is one of the leading causes death worldwide. Although several drugs are used clinically, some tumors either do not respond or resistant to existing pharmacotherapy, thus justifying search for new drugs. Ursolic acid (UA) a triterpene found in different plant species that has been shown possess significant antitumor activity. However, UA presents low solubility aqueous medium, which barrier its biological applications. In this context, use liposomes promising strategy deliver and...
Objetivo: Investigar como os avanços na compreensão dos mecanismos moleculares da calcificação valvar podem impactar o desenvolvimento e a eficácia das novas terapias emergentes para tratamento dessa condição, comparando com métodos tradicionais. Métodos: Esta revisão integrativa literatura. PubMed Biblioteca Virtual em Saúde (BVS), focando artigos publicados nos últimos cinco anos, entre 2019 2024. O objetivo foi identificar estudos que abordassem Calcificação Válvula Aórtica (CAVD)...
Herein, we present a versatile and efficient continuous flow protocol for the synthesis of structurally diverse butenolides coumarins through in situ generation acylketenes via retro hetero-Diels-Alder...
A gestação é um período marcado por profundas mudanças biológicas, psicológicas e sociais, que podem exacerbar ou desencadear transtornos psiquiátricos em mulheres predispostas. As emergências psiquiátricas, como de humor, ansiedade, psicose uso substâncias, requerem intervenções rápidas devido ao seu impacto na saúde materna nos desfechos obstétricos. O objetivo dessa pesquisa consistiu explorar as principais condições psiquiátricas emergenciais, suas implicações para a materno-fetal...
Topical therapy is the first choice for treatment of mild to moderate acne and all-trans retinoic acid one most used drugs. The combination retinoids antimicrobials an innovative approach therapy. Recently, lauric acid, a saturated fatty has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application followed by high incidence side-effects, including erythema irritation. Solid lipid nanoparticles represent alternative overcome these side-effects. This...
Doxorubicin (DOX) is an anthracycline antibiotic widely used in the treatment of cancer, however, it associated with occurrence adverse reactions that limits its clinical use. In this context, encapsulation DOX micelles responsive to pH variations has shown be a strategy for tumor delivery drug, potential increase therapeutic efficacy and reduce toxic effects. addition, radiolabeling nanoparticles radioactive isotope great use preclinical studies, since allows vivo monitoring nanostructure...
Paromomycin (PA), a very hydrophilic antibiotic, has been tested as an alternative topical treatment against cutaneous leishmaniasis (CL). Although this shown promising results, it not successful in accelerating the recovery most cases. This could be attributed to low skin penetration of PA. Liposomal formulations usually provide sustained and enhanced drug levels skin. The aim study was prepare liposomal containing PA investigate their potential delivery systems antileishmanial. Large...