A5043471477- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Advancements in Transdermal Drug Delivery
- Injection Molding Process and Properties
- biodegradable polymer synthesis and properties
- Dermatology and Skin Diseases
- Essential Oils and Antimicrobial Activity
- Microencapsulation and Drying Processes
- Drug Solubulity and Delivery Systems
- Trypanosoma species research and implications
- Hair Growth and Disorders
- Computational Drug Discovery Methods
- Biosimilars and Bioanalytical Methods
- Facial Rejuvenation and Surgery Techniques
- Nonlinear Optical Materials Research
- Polymer crystallization and properties
- Bioactive Compounds and Antitumor Agents
- Parasite Biology and Host Interactions
- Bee Products Chemical Analysis
- Advanced Polymer Synthesis and Characterization
- Synthesis and Biological Evaluation
- Protein purification and stability
- Nanoparticle-Based Drug Delivery
- Helminth infection and control
- Biochemical and Molecular Research
Universidade de Brasília
2020-2025
Cosmetics Europe
2025
Background/Objectives: Chagas disease is a neglected tropical caused by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. This work aimed first time formulate tablets of hot melt extrusion coupled 3D printing as strategy increase drug dissolution production dosage on demand. Methods: Different pharmaceutical-grade polymers were evaluated through...
One of the challenges in developing three-dimensional printed medicines is related to their stability due manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging medicines, tested regarding morphology thermal, crystallographic, spectroscopic profiles. Generally, despite strong drug-polymer interactions observed, chemical model drugs was preserved under such conditions. In fact, metoprolol...
Alopecia areata is managed with oral corticosteroids, which has known side effects for patients. Given that a topical application of formulations containing corticoid and substance controlling hair loss progression could reduce or eliminate such adverse increase the patient's adherence to treatment, this study prepares polymeric lipidic nanoparticles (PNPs NLCs) co-entrap minoxidil betamethasone compares follicular drug delivery provided by these nanoparticles. The prepared PNPs loaded 99.1...
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for first time. For this, a combined mixture design was employed using paracetamol as model drug. Extrudates were obtained under reduced torque (up 0.3 Nm) at 100 °C preserve stability salts. Formulations showed vigorous and rapid disintegration (<3 min), adequate flow characteristics, complete solubilization instantly after reaction. containing PVPVA in concentration range 15-20% m/m...
This work aimed to develop a three-dimensional (3D) wearable drug-loaded earring tap treat affections caused by aesthetic perforations. The initial phase involved combination of polymers prepare filaments for fused deposition modeling (FDM) 3D printing using centroid mixture design. Optimized filament compositions were used in the second produce printed taps containing anti-inflammatory naringenin. Next, samples assessed via physicochemical assays followed vitro skin permeation studies with...
A novel sanitizer tablet containing clove essential oil (CO) microemulsion was developed. preformulation study using nuclear magnetic resonance and thermal analyses showed component compatibility. The main components of the samples remained intact despite a color change, probably due to strong acid-base interaction between eugenol diethanolamine. CO acaricidal larvicidal activities superior commercial product, with product efficacy 99.9% larvae mortality 94%. Optimal spray-drying conditions...