A5026813880- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Oral health in cancer treatment
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Dermatology and Skin Diseases
- Oral Health Pathology and Treatment
- Microencapsulation and Drying Processes
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Crystallization and Solubility Studies
- Entomopathogenic Microorganisms in Pest Control
- Phytochemistry and biological activity of medicinal plants
- Head and Neck Cancer Studies
- Bee Products Chemical Analysis
- Insect Pest Control Strategies
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Nail Diseases and Treatments
- Phytochemistry Medicinal Plant Applications
- Protein purification and stability
- Lipid Membrane Structure and Behavior
- Proteins in Food Systems
Universidade Federal de Goiás
2015-2024
Nanosys (United States)
2021
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2016
National Council for Scientific and Technological Development
2016
Fundação de Apoio a Pesquisa do Estado de Goiás
2015-2016
Universidade de Brasília
2016
Universidade de São Paulo
2006-2014
Universidade Estadual de Goiás
2012
Universidade Federal de Sergipe
2008
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate effects process formulation variables on properties via Box-Behnken design. Liquid SMEDDS were developed, carvedilol was used as a class II model drug. Mean size, polydispersity index (PdI) zeta resulting microemulsions...
Abstract Objectives The aim of this study was to investigate in vitro the epidermal targeting potential clobetasol propionate-loaded nanostructured lipid carriers (CP-NLC) when compared that chitosan-coated (CP-NLC-C). Methods CP-NLC were prepared by microemulsion method and characterized dynamic light scattering, transmission electron microscopy, release permeation studies. To verify targeting, studies performed two sets experiments. For first set, skin removed from diffusion cell stratum...
This study was aimed to microencapsulate fish oil (FO) in two biocompatible polymeric blends: gum arabic (GA)-maltodextrin (MD) and casein-pectin (CP)-MD. GA-MD microparticles CP-MD were produced by spray-drying complex coacervation spray-drying, respectively. Encapsulation efficiency, particle size, moisture content, oxidative stability, morphological properties analysed. efficiencies of 51.2-56.8% (w/v) for GA 64.7-67.9% CP preparations found. sizes varied from 2 100 μm 120 microparticles....
Gatifloxacin (GAT), a fourth-generation fluoroquinolone, is currently marketed primarily in the form of eye drops. The literature shows physical-chemical methods with predominance use toxic organic solvents, which promote generation potentially harmful residues both for environment and operator. objective was to develop validate an excellent green method visible region quantification GAT Purified water NaOH 0.1 M, as diluent, phenolphthalein 1 %, reaction, at 552 nm were used. linear range...
To design and evaluate the potential of a topical delivery system for ocular administration voriconazole, based on cationic nanostructured lipid carriers (NLCs).NLC dispersions composed glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, cetylpyridinium chloride were obtained characterized. Ex vivo permeations experiments performed to their drug potential.NLCs presented mean diameter 250.2 ± 03.1 nm, narrow polydispersity index (0.288 0.03), positive zeta...
Clobetasol propionate (CP) is a potent topical corticosteroid that causes several cutaneous and systemic side effects. In the present work, CP was encapsulated in nanostructured lipid carriers (NLCs) to increase drug retention outer skin layers improve safety of therapy. NLCs were prepared using microemulsion technique with mixture lecithin, taurodeoxycholate, stearic acid, oleic acid. vitro penetration studies performed modified Franz-type diffusion cell, porcine ears used as model human...
The formation of inclusion complexes Hyptis pectinata essential oil (EOHP), with potent activities such as anti-nociceptive, anti-inflammatory, among others, β -cyclodextrin (β-CD), was obtained by slurry (SC) and paste procedures (PC). gas chromatography coupled to the mass spectrometry (GC/MS) analysis demonstrated a total 36.4% monoterpenes 63.6% sesquiterpenes in EOHP. major components EOHP were identified (E)- caryophyllene (54.07%). samples (PM, PC SC) GC/MS involved surface extracted...
Gastrointestinal mucositis induced during cancer treatment is considered a serious dose-limiting side effect of chemotherapy and/or radiotherapy. Frequently, interruption the due to this pathology leads reduction in cure rates, increase costs and decrease life quality patient. Natural products such as Bidens pilosa L. (Asteraceae), represent potential alternative for given its anti-inflammatory properties. In study, B. glycolic extract was formulated (BPF) with poloxamer, mucoadhesive...
Intestinal mucositis is a frequent limiting factor in anticancer therapy and there currently no broadly effective treatment targeted to cure this side effect.This study aimed evaluate the effects of mucoadhesive formulation containing curcuminoids (MFC) from Curcuma longa L. on pathogenesis 5-fluorouracil (5-FU)-induced intestinal mucositis.Three intraperitoneal 5-FU injections (200 mg/kg) were used induce adult Swiss male mice. Treatment was provided orally (MFC 3.75, 7.5 15 mg/kg), thirty...
ABSTRACT This study evaluates the performance of conventional spouted beds (CSB) with inert bodies in drying pharmaceutical pastes, based on dry product quality. The powder obtained by annatto extracts shows properties comparable to one commercial products, indicating that spouting is competitive other industrial and lab-scale processes. contents bixin caffeine guarana powders demonstrated a strong dependence inlet air temperature. Also, indomethacin-containing microcapsules dried CSB spray...