A5047236873- Essential Oils and Antimicrobial Activity
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Cerebrovascular and genetic disorders
- Healthcare and Venom Research
- Restless Legs Syndrome Research
- Atherosclerosis and Cardiovascular Diseases
- Phytochemistry Medicinal Plant Applications
- Medicinal Plants and Neuroprotection
- Ocular Surface and Contact Lens
- Blood Coagulation and Thrombosis Mechanisms
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Neurological Disease Mechanisms and Treatments
- Microencapsulation and Drying Processes
- Venomous Animal Envenomation and Studies
- Bee Products Chemical Analysis
- Food Safety and Hygiene
- Biochemical effects in animals
- Systemic Lupus Erythematosus Research
- Insect and Pesticide Research
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Biomarkers in Disease Mechanisms
Universidade de Brasília
2016-2025
Centro Universitário Central Paulista
2024
Comissão Executiva do Plano da Lavoura Cacaueira
2024
Keck Hospital of USC
2019-2023
Faculdade Brasil
2018-2020
University of Southern California
2018-2020
Keck Graduate Institute
2019
Polytechnic Institute of Porto
2019
University of Lisbon
2017
Icahn School of Medicine at Mount Sinai
2012-2016
Alzheimer's disease (AD) is the most prevalent neurodegenerative of aging and currently has no cure. Its onset progression are influenced by multiple factors. There growing consensus that successful treatment will rely on simultaneously targeting pathological features AD. Polyphenol compounds have many proven health benefits. In this study, we tested hypothesis combining three polyphenolic preparations (grape seed extract, resveratrol, Concord grape juice extract), with different...
The present work reports the influence of presence different ions (Cl − , Br NO 3 or SO 4 2− ) on formation and proprieties Cu(II) complexes with pyridoxal-benzoylhydrazone (PLBHZ). Four new were successfully synthesized, [CuCl 2 (PLBHZ)] (1), [CuBr (2), [CuCl(PLBHZ)H O]⋅NO ⋅H O (3), [CuSO (PLBHZ)H O]⋅3H (4), characterized by spectroscopic physicochemical methods. A single-crystal X-ray study reveals Schiff base coordinated to metal center tridentate ONS -donor system, resulting in distorted...
Aim: Secretion of proteins into basal tears Parkinson's disease (PD) patients may be altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total α-SynTotal, CCL-2, DJ-1, LF MMP-9 were measured from 93 PD 82 age- sex-equivalent healthy controls. Results: α-SynTotal was decreased (p = 0.0043), whereas < 0.0001) the ratio α-SynOligo/α-SynTotal increased compared with Area under receiver-operating curves contents 0.70 (95% confidence limits: 0.621–0.774) 0.72...
We describe here a green method for the preparation of silver nanoparticles (AgNPs), by microwave-assisted synthesis route using Handroanthus impetiginosus underbark extract, with antibacterial activity. After optimizing parameters Box-Benhken designed experiment, samples were characterized powder XRD, TEM, UV-Vis spectroscopy, FTIR and zetametry. Using overall optimized conditions - time reaction 15 min at 200 °C plant extract/AgNO3 volume ratio equal to 10% highly crystalline ∼13.4...
Background/Objectives: This study aimed to develop gel nanoemulsions (NEs) of Brazilian essential oils (EOs) from Eugenia uniflora and Psidium guajava, as well perform chemical characterization investigate the antimicrobial activity EOs NEs. Results/Conclusions: The main compounds E. EO were curzerene (34.80%) germacrene B (11.92%), while those P. guajava β-caryophyllene (25.92%), β-selinene (22.64%), γ-selinene (19.13%). NEs had droplet sizes 105.30 99.50 nm polydispersity index (PDI)...
ABSTRACT The prevalence of childhood/adolescent obesity and insulin resistance has reached an epidemic level. Obesity's immediate clinical impacts have been extensively studied; however, current evidence underscores the long‐term implications. study explored brief on cognitive function in later life. To mimic resistance, we exposed 9‐week‐old C57BL/6J mice to a high‐fat diet for 15 weeks, after which exhibited diet‐induced resistance. We then put these back normal low‐fat diet, body weight...
Scope Metabolic syndrome has become an epidemic and poses tremendous burden on the health system. People with metabolic are more likely to experience cognitive decline. As obesity sedentary lifestyles common, development of early prevention strategies is critical. In this study, we explore potential beneficial effects a combinatory polyphenol preparation composed grape seed extract, Concord purple juice resveratrol, referred as standardized (SGP), peripheral well brain dysfunction induced by...
Traumatic brain injury (TBI) is a leading cause of death and disability among children young adults in the United States. In this study, we explored whether changes gene expression profile peripheral blood mononuclear cells (PBMC) may p
Aim: Due to active engagement of sensory and afferent nerve fibers in reflex tearing which could be affected Parkinson's disease (PD), we tested tears as a source potential PD biomarkers. Patients & methods: Reflex collected from 84 age- sex-equivalent healthy controls (HC) were used measure levels oligomeric α-Syn (α-SynOligo), total (α-SynTotal), CCL2, DJ-1, lactoferrin MMP9. Results: α-synOligo (p < 0.0001), CCL2 = 0.003) 0.002) significantly elevated patient relative HC tears. Tear flow...
The aim of this study was to evaluate the physicochemical composition and antibacterial activity Brazilian propolis extracts from different types, concentrations, extraction solvents regions in Brazil. A total 21 samples were analyzed, comprising 14 Apis mellifera (12 green, 1 brown, red) 7 stingless bees (3 mandaçaia, 2 jataí, hebora, tubuna). analyses performed dry extract, phenolic content (TPC) antioxidant (DPPH ABTS). by Determination Minimal Inhibitory Concentration (MIC) Bactericidal...
Alzheimer's disease (AD) is rapidly becoming one of the leading causes disability and mortality in elderly. As life-expectancy increases, an increasing number people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others exacerbate, pathogenesis AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity identified that can potentially influence amyloid precursor protein processing. In this study, we...
Nanoformulation with AgNPs derived from P. sidoides extract demonstrates potent antimicrobial efficacy against pathogenic bacteria including drug-resistant strains.
Tears are a known source of biomarkers for both ocular and systemic diseases with particular advantages; specifically, the noninvasiveness sample collection unique increasingly better-defined protein composition. Here, we discuss our rationale use tears discovery Parkinson's disease (PD). These reasons include literature supporting changes in tear flow composition PD, interconnections between surface system neurons affected PD. We highlight recent data on identification including oligomeric...
Abstract The rising number of multidrug‐resistant microorganisms has triggered interest in the prospection biocompounds with antimicrobial activities. Synoeca‐MP consists an peptide (AMP) classified as a mastoparan, which was isolated from venom Synoeca surinama , social wasp. presented potent activity, values MIC 50 and 90 against methicillin‐resistant Staphylococcus aureus —MRSA (1.9 2.2 μM), Escherichia coli ESBL (2.0 2,1 vancomycin‐resistant Enterococcus faecalis (8.3 17.1 Pseudomonas...
Recent evidence suggests decreased expression of synaptic-related genes and loss synapses in major depressive disorder (MDD), the pre-synaptic-related is accompanied by an increased depression-associated transcription factor GATA1 transcriptional factor. Depression also linked to cognitive decline, including Alzheimer disease (AD), but exact nature relationship poorly understood. In this study, we explored postmortem AD brains examined causal effect on amyloid processing neuronal cells...
This study aimed to evaluate the chemical and antibacterial properties of essential oil B. dracunculifolia from three regions Brazil: Midwest, Southeast South region. The major compounds Midwest region were (E)-nerolidol (28.15%) spathulenol (17.68%), both oxygenated sesquiterpenes. And oils (12.75–13.95%), bicyclogermacrene (10.76–14.21%) limonene (10.49–19.36%). showed activity for Gram-positive Gram-negative bacteria tested, with MIC values 0.03 0.15 mg/mL MBC 0.05 0.30 mg/mL. Brazil...
Pathological anxiety is among the most common psychiatric illnesses, but current treatment highly limited. In this study, we investigated potential anxiolytic-like effects of a peptide isolated from Synoeca surinama venom. Rats treated with spent more time exploring open arms elevated plus maze, which indicates an profile for peptide. This study first to show pharmacological use S. venom in anxiety.
The detection of pathogenic microorganisms in aquatic environments is extremely relevant terms public health. As these laboratorial methodologies are usually difficult, expensive and time-consuming, they frequently replaced by the assessment fecal indicator bacteria, such as Escherichia coli. This study aimed to assess presence E. coli samples from Neotropical otters, evaluate its potential be applied determination water microbiological quality areas where otters' populations high....