A5086265192- Salivary Gland Disorders and Functions
- Ocular Surface and Contact Lens
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Diabetes and associated disorders
- Adsorption and biosorption for pollutant removal
- Connective tissue disorders research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bioactive Compounds and Antitumor Agents
- Graphene and Nanomaterials Applications
- Analytical chemistry methods development
- Ionic liquids properties and applications
- Systemic Sclerosis and Related Diseases
- Cellular Mechanics and Interactions
- Graphene research and applications
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Advancements in Transdermal Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Protease and Inhibitor Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Skin Protection and Aging
University of Southern California
2017-2025
Southern California Eye Institute
2021-2025
Birla Institute of Technology and Science, Pilani
2012-2015
Birla Institute of Technology and Science - Hyderabad Campus
2014
Background Sjögren’s Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the protein-rich aqueous component tears, SjD-associated dacryoadenitis (AD) may thus alter tear autoantibody composition. Methods presence tertiary lymphoid structures (TLS) in from two murine models AD, male non-obese diabetic (NOD) insulitis resistant (NOR) mice, were evaluated using immunofluorescence. IgG IgA reactivity serum tears...
The tear miRNAome of the male NOD mouse, a model ocular symptoms Sjögren's syndrome (SS), was analyzed to identify unique miRNAs. Male mice, aged 12-14 weeks, were used miRNAs associated with development autoimmune dacryoadenitis. Age- and sex-matched BALB/c mice served as healthy controls while age-matched female that do not develop dacryoadenitis characteristic SS additional controls. Total RNA isolated from stimulated tears pooled 5 per sample sequenced analyzed. Putative miRNA hits...
Sjögren's Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and loss of function moisture-producing exocrine glands as well systemic inflammation. SS diagnosis cumbersome, subjective complicated manifestation symptoms that overlap with those other rheumatic ocular diseases. Definitive averages 4-5 years this delay may lead to irreversible tissue damage. Thus, there urgent need for diagnostic biomarkers earlier detection SS. Extracellular vesicles called...
Tears are a known source of biomarkers for both ocular and systemic diseases with particular advantages; specifically, the noninvasiveness sample collection unique increasingly better-defined protein composition. Here, we discuss our rationale use tears discovery Parkinson's disease (PD). These reasons include literature supporting changes in tear flow composition PD, interconnections between surface system neurons affected PD. We highlight recent data on identification including oligomeric...
Recombinant Elastin-Like Polypeptides (ELPs) serve as attractive scaffolds for nanoformulations because they can be charge-neutral, water soluble, high molecular weight, monodisperse, biodegradable, and decorated with functional proteins. We recently reported that fusion of the FK-506 binding protein 12 (FKBP) to an ELP nanoparticle (FSI) reduces rapamycin (Rapa) toxicity enables intravenous (IV) therapy in both a xenograft breast cancer model murine autoimmune disease model. Rapa has poor...
Abstract In this study, we explored the pharmaceutically underexploited mycobacterial gyrase ATPase (GyrB) domain as a template for structure‐based virtual screening of our in‐house (BITS Pilani) compound collection to discover new inhibitors targeting Mycobacterium tuberculosis ( M.tb. ) The hit identified was further customized by using combination molecular docking and medicinal chemistry strategies obtain an optimized analogue displaying considerable in vitro enzyme efficacy bactericidal...
Purpose: To analyze the changes in lacrimal gland (LG) miRNAome from male nonobese diabetic (NOD) mice with autoimmune dacryoadenitis compared LG healthy BALB/c and dacryoadenitis-free female NOD mice. Methods: these were collected for small RNA sequencing to identify dysregulated miRNAs; hits validated by RT-qPCR LG. Dysregulation of species within immune cell–enriched cell fractions epithelial-enriched was probed RT-qPCR. Ingenuity pathway analysis identified putative miRNA targets, which...
The objective of this study is to synthesize and evaluate 1-(4-chlorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrobenzylidene) pyrazolidine-3,5-dione (CD59) analogues establish structure-activity relationship mechanism action. Thirty reported antitubercular CD59 were prepared by two-step synthetic protocols characterized. compounds evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity RAW 264.7 cells. molecules also three mycobacterial enzymes the Among compounds,...
Sjögren's Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the protein-rich aqueous component tears, SjD-associated dacryoadenitis (AD) may thus alter tear autoantibody composition.
<h3>Objective:</h3> We performed an RNA-Seq analysis of tears from 16 Parkinson's Disease (PD) patients and healthy, age-matched healthy controls (HC) to identify genes pathways that may serve as biomarkers PD. <h3>Background:</h3> previously demonstrated PD have significantly higher levels oligomeric a-synuclein than HC tears. Analyses hundreds subjects this biomarker predicted diagnosis, irrespective disease duration (AUROC=0.76). To improve model, we on Pilot studies brain revealed ~74%...
ABSTRACT Objective The tear miRNAome of the male NOD mouse, a model ocular symptoms Sjögren’s syndrome (SS), was analyzed to identify possible biomarkers disease. Methods Male mice, aged 12-14 weeks, were used miRNAs associated with development autoimmune dacryoadenitis. Age-matched female mice that do not develop dacryoadenitis characteristic SS as negative controls while age- and sex-matched BALB/c served healthy controls. Total RNA isolated from stimulated tears pooled 5 per sample...