A5101815188- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Advanced Neuroimaging Techniques and Applications
- Corneal surgery and disorders
- Immune Response and Inflammation
- Intraocular Surgery and Lenses
- EEG and Brain-Computer Interfaces
- Acne and Rosacea Treatments and Effects
- Retinal and Macular Surgery
- Empathy and Medical Education
- Retinal and Optic Conditions
- Diversity and Career in Medicine
- Memory and Neural Mechanisms
- Advances in Oncology and Radiotherapy
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Genetic Neurodegenerative Diseases
- Immune Cell Function and Interaction
- Food Security and Health in Diverse Populations
- Infant Development and Preterm Care
- Inflammasome and immune disorders
Human Longevity (United States)
2024
University of California, San Diego
2024
University of Southern California
2015-2024
Southern California Eye Institute
2020-2024
Washington University in St. Louis
2018-2019
New York Eye and Ear Infirmary
2017
University of California, Irvine
2015
ENT and Allergy
2012
Resting-state functional magnetic resonance imaging (fMRI) has provided converging descriptions of group-level brain organization. Recent work revealed that networks identified in individuals contain local features differ from the description. We define these as network variants. Building on studies, we ask whether distributions variants reflect stable, trait-like differences Across several datasets highly-sampled show 1) are highly stable within individuals, 2) found characteristic...
Control over behavior is enabled by the brain's control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated specialized "connector hub" regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, although unitary nature dubious when examined in individual brains. Here we investigated using fMRI characterize individual-specific hub two independent...
Tregs expressing the transcription factor Foxp3 suppress self-reactive T cells, prevent autoimmunity, and help contain immune responses to foreign antigens, thereby limiting potential for inadvertent tissue damage. Mutations in FOXP3 gene result Treg deficiency mice humans, which leads development of a multisystem autoimmune inflammatory disease. The contribution dysregulated innate pathogenesis disease is unknown. In this study, we examined role microbial signals by studying mutant that had...
<h3>Importance</h3> Affordable, quantitative methods to screen children for developmental delays are needed. Motor milestones can be an indicator of delay and may used track progress. Accelerometry offers a way gather real-world information about pediatric motor behavior. <h3>Objective</h3> To develop referent cohort accelerometry from bilateral upper extremities (UEs) determine whether movement accurately distinguish those with without deficits. <h3>Design, Setting, Participants</h3>...
Objective: We evaluated the safety and efficacy of an augmented BroadBand Light (BBL™) protocol on upper lower eyelids in improving meibomian gland dysfunction (MGD) and/or dry eye disease (DED). Background: DED, often associated with MGD, can cause significant morbidity accounts for 3.54 billion U.S. dollars health care spending yearly. Intense pulsed light (IPL) has been used to treat MGD DED some success. BBL therapy, a high-quality IPL machine, shows much promise decreasing inflammation...
Gender disparities in the field of ophthalmology have been increasingly recognized. Although mentorship has proposed as a contributing factor, there are limited data on differences experiences by gender among ophthalmologists.
The tear miRNAome of the male NOD mouse, a model ocular symptoms Sjögren's syndrome (SS), was analyzed to identify unique miRNAs. Male mice, aged 12-14 weeks, were used miRNAs associated with development autoimmune dacryoadenitis. Age- and sex-matched BALB/c mice served as healthy controls while age-matched female that do not develop dacryoadenitis characteristic SS additional controls. Total RNA isolated from stimulated tears pooled 5 per sample sequenced analyzed. Putative miRNA hits...
Abstract Objectives Characterize the relationship between infant outcomes and prenatal homelessness, food insecurity unemployment. Study design California live births 22- 44-weeks’ gestation comprised 6,089,327 pregnancies (2007–2020). Data were collected from linked Vital Statistics hospital discharge records. Prenatal insecurity, unemployment classified as health-related social needs (HRSN) using International Classification of Disease codes in delivery Risk ratios for preterm birth, low...
Complementary and alternative medicine (CAM) is widely used by adults in the USA. However, most physicians do not inquire about CAM use leading to missed opportunities dialogue wellness detect harmful practices. In 2012, an integrative (IM) consultation clinic alongside optional IM Residency Track for family residents was established at University of California, Irvine Family Health Center Santa Ana, CA. This study evaluated impact these programmes on physicians’ CAM/IM knowledge...
The breakdown of dominant tolerance mediated by CD4+Foxp3+ T regulatory cells results in severe inflammatory skin disease and colitis. Under normal conditions, commensal bacteria reside at mucosal surfaces the without generating an response. We hypothesized that FoxP3-deficient mice, normally innocuous trigger response via toll-like receptor (TLR) signaling. To test this hypothesis, we examined evolution TLR adaptor protein MyD88/FoxP3 double knockout mice. MyD88 deficiency FoxP3 mice...
Control over behavior is enabled by the brain's control networks, which interact with lower-level processing networks to regulate their functions. Such interactions are facilitated specialized "connector hub" regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, though unitary nature dubious when examined in individual brains. Here, we investigated using functional magnetic resonance imaging characterize individual-specific hub two...
Abstract We investigate the perception of financial exploitation and its causes consequences by older adults who have firsthand experience being exploited. Thirty-one cognitively healthy adult participants aged 50 or were drawn from Finance, Cognition, Health in Elders Study. In-depth, one-on-one interviews conducted. Interview transcripts analyzed using an iterative, data-driven, thematic coding scheme emergent themes summarized. Categories included (a) investment fraud, (b) wage...
OPINION article Front. Ophthalmol., 06 February 2023Sec. Inflammatory Eye Diseases Volume 3 - 2023 | https://doi.org/10.3389/fopht.2023.958955