A5023849192- Clinical practice guidelines implementation
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Antenna Design and Analysis
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Lymphoma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
- Orthopedic Surgery and Rehabilitation
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Ocular Oncology and Treatments
- Forensic Toxicology and Drug Analysis
- Salivary Gland Tumors Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Potassium and Related Disorders
- Hedgehog Signaling Pathway Studies
University of Southern California
2013-2024
University of Calgary
2021-2024
Los Angeles Medical Center
2017-2024
St. Paul's Hospital
2023
Keck Hospital of USC
2023
University of British Columbia
2022
Northwestern University
2021
Mayo Clinic Hospital
2017
NorthShore University HealthSystem
2015
USC Norris Comprehensive Cancer Center
2013
Purpose: To evaluate the efficacy of topical rapamycin in treating autoimmune dacryoadenitis a mouse model Sjögren's syndrome. Methods: We developed poly(ethylene glycol)-distearoyl phosphatidylethanolamine (PEG-DSPE) micelle formulation to maintain solubility. Rapamycin or PEG-DSPE eye drops (vehicle) were administered well-established syndrome disease model, male nonobese diabetic (NOD) mice, twice daily for 12 weeks starting at 8 age. Mouse tear fluid was collected and Cathepsin S,...
Purpose The aim of this study was to determine the prognostic significance PET/CT findings in women with cervical cancer and describe normalization lymph node SUV max (nSUV ). Materials Methods A retrospective review performed 113 patients who underwent a before receiving definitive therapy. measurements were normalized pelvic blood pool. Patient, tumor, data correlated extracervical recurrence-free survival (ecRFS) pathology. Results Of patients, there 23 (20%) recurrences. On univariate...
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. tumors display neuroendocrine features and polyomavirus (MCPyV) infection in the majority (80%) of patients. Although loss histone H3 lysine 27 trimethylation (H3K27me3) has been shown during MCC tumorigenesis, epigenetic dysregulation largely overlooked. We conducted global DNA methylation profiling clinically annotated primary tumors, metastatic lymph node paired normal tissues, two human...
Abstract Introduction Obesity is an established risk factor for recurrent atrial fibrillation (AF) after ablation. The impact of pre‐procedure weight changes on freedom from AF (FFAF) ablation in obese and nonobese patients unknown. Methods A single‐center retrospective cohort study undergoing pulmonary vein isolation was performed. Before ablation, all candidates were encouraged to adopt healthy lifestyle habits according American Heart Association guidelines, including loss, by their...
Recombinant Elastin-Like Polypeptides (ELPs) serve as attractive scaffolds for nanoformulations because they can be charge-neutral, water soluble, high molecular weight, monodisperse, biodegradable, and decorated with functional proteins. We recently reported that fusion of the FK-506 binding protein 12 (FKBP) to an ELP nanoparticle (FSI) reduces rapamycin (Rapa) toxicity enables intravenous (IV) therapy in both a xenograft breast cancer model murine autoimmune disease model. Rapa has poor...
Merkel cell carcinoma (MCC) is an aggressive, neuroendocrine of the skin with incidence 2,000 cases per year, and a 5-year survival rate 30% to 64%.1 Risk factors for MCC include advanced age, fair skin, immunosuppression, including history organ transplantation, HIV, lymphoproliferative disorders.1-3 presents clinically as rapidly growing cutaneous nodule frequent locoregional involvement. Although surgery radiation are mainstays treatment, management distant disease more challenging.
Approximately 4 million cases of nonmelanoma skin cancer affecting 2.5 individuals were diagnosed in the United States 2012, with nearly half being cutaneous squamous cell carcinoma (CSCC).1 Risk factors for development CSCC include ultraviolet exposure, older age, and immunosuppression.2 There are no standard guidelines to manage advanced or recurrent CSCC. Various systems have been devised predict which patients at high risk recurrence metastasis, based on clinical pathologic...
Objective: To identify clinically relevant predictive biomarkers of trastuzumab resistance.Material and methods: MTT, FACS assays, immunoblotting immunocytochemistry were used to phenotypically characterize drug responses two cell models BT474R SKBR3R. Student's t-test Spearman's correlation applied for statistic analysis.Results: The activity a downstream effector the HER2 pathway phosphorylated ribosomal protein S6 (p-rpS6), was suppressed by in parental lines yet remained unchanged...
Cutaneous myoepithelial neoplasms are a heterogenous group of with mixed tumors typically affecting the head and myoepitheliomas showing predilection for extremities. Their malignant counterparts, carcinoma, tumor exceptionally rare in skin, morphologic criteria malignancy only poorly defined. The aim present study was to characterize clinicopathologic features presenting on acral skin. clinical histopathologic 11 were recorded, follow-up obtained. Immunohistochemistry performed S100, SOX10,...
Abstract Catastrophic antiphospholipid antibody syndrome (CAPS) is a rare form of syndrome, an autoimmune condition characterized by vascular thromboses, pregnancy loss, and (aPL) antibodies. Diagnosis CAPS relies on thrombosis at least three different organs systems over 1 week, histopathological evidence small vessel occlusion, high aPL titers. In subset precipitating circumstances, activation or disruption endothelial cells in the microvasculature may occur along with cardiomyopathy. We...
Abstract The clinical benefit from trastuzumab (T) in HER2-positive breast cancers is limited by de novo or acquired resistance. By serial exposure of HER2+ cancer cell lines BT474 and SKBr3 to T at 200 µg/ml for 1 year clonogenic selection, we have developed T-resistant identified differentially expressing genes including consistent overexpression CXCR4 the mRNA protein levels. involved metastasis proliferation its human specimens linked poor prognosis. We sought functionally validate as a...
Aims Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterised by malignant transformation of a pre‐existing benign trichoblastoma, subdivided histologically into low‐grade high‐grade tumours. Whereas morphologically trichoblastic show indolent behaviour, have been associated with poor prognosis, but little is known about their true biological potential. The aim this study was to better define the clinicopathological features outcomes...
Aims Plaque‐type blue naevi are rare melanocytic tumours presenting as large, pigmented plaques at birth or during childhood. There is a risk for malignant transformation, but no larger comprehensive studies exist and the diagnosis challenging, especially on limited biopsy material. The aim to describe clinicopathological features behaviour of disease more comprehensively. Methods results We retrieved eight plaque‐type naevi, (median = 7 cm; range 3–26) most frequently affecting scalp (four)...
Basal cell carcinoma (BCC) is the most common malignancy in United States. The majority of cases are identified Non-Hispanic Whites (NHW) and far less demonstrated patients colour (POC). However, Hispanic population represents a large growing proportion US population, skin cancer diagnoses Hispanics rising. Thus, goal this study to examine clinicopathologic differences between BCC versus NHW.
Sleep, a fundamental human need, plays critical role in our physical, mental, and emotional health. Despite its importance, modern society often views sleep as luxury rather than necessity. This paper delves into the profound impact of rest on well-being, drawing wide array interdisciplinary research from neurology, psychology, public health to illuminate consequences deprivation transformative power quality sleep. Through quantitative analyses qualitative case studies, we examine...
The behavior of phyllodes tumors is unpredictable and can behave as benign fibroadenomas or malignant neoplasms mimicking the course aggressive sarcomas, characterized by distant metastases a high short-term mortality. forms are treated with surgery adjuvant chemotherapy, but often poor outcomes. We examine first reported case an osteosarcoma subtype tumor that recurred in skull after total mastectomy chemotherapy. lesion was excision, patient currently remains disease-free.
609 Background: Thetargeting of HER2/neu oncoprotein with trastuzumab (Herceptin) has altered the natural history HER2+ breast cancer, however, its clinical benefit is limited by de novo and/or acquired resistance which almost always develops in advanced setting. While several mechanisms have been postulated, none are validated for use to best select patients treatment. Our study aims were identify predictive biomarkers based on reproducible differences HER2 initiated signaling pathway...