A5084151681- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Diet and metabolism studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pineapple and bromelain studies
- Medical Coding and Health Information
- Electroconvulsive Therapy Studies
- Nanocomposite Films for Food Packaging
- Neonatal and fetal brain pathology
- Voice and Speech Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood properties and coagulation
- Sleep and Wakefulness Research
- Biosimilars and Bioanalytical Methods
Northwestern University
2016-2025
Northwestern Memorial Hospital
2016-2025
University Medical Center
2024
Northwestern Medicine
2023
All India Institute of Medical Sciences Bhubaneswar
2021
Athens Euroclinic
2017
Cleveland Clinic
2017
Harvard University
2013
Background Catheter ablation is an established treatment for atrial fibrillation (AF). Cryoballoon (CBA) has emerged as alternative to radiofrequency (RFA). However, there are few data comparing these modalities of paroxysmal AF (pAF) in the U.S. population. The purpose this study was compare procedural times, safety, and efficacy CBA against RFA. Methods A single‐center prospective cohort evaluated patients who underwent catheter pAF using or RFA between January 1, 2010 October 31, 2013....
BackgroundLoading oral sotalol for atrial fibrillation (AF) requires 3 days, frequently in-hospital, to achieve steady state. The FDA approved loading with intravenous (IV) through model-informed development, without patient data.ObjectiveWe present results of the first multicenter evaluation this recent labeling IV sotalol.MethodsThe Prospective Evaluation Analysis and Kinetics Sotalol (PEAKS) Registry was a observational registry patients undergoing elective load arrhythmias. Outcomes,...
Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL). Despite its efficacy, sotalol's use limited by potential cause life-threatening ventricular arrhythmias due QT interval prolongation. Traditionally, sotalol administration required hospitalization monitor these risks. The FDA approval of intravenous (IV) for loading before oral maintenance aims reduce duration facilitating an expedited dose, transitioning...
ABSTRACT Background Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there discretion regarding dosing chronic therapy, and target oral dose dictates infusion doses intravenous sotalol loading. To date, use outcomes by are not well‐described. Methods In Prospective Evaluation Analysis Kinetics IV (PEAKS) Registry, we analyzed undergoing elective load arrhythmias (AT/AF). Baseline characteristics, changes in ECG parameters, in‐hospital...
Cryoballoon ablation (CBA) for paroxysmal atrial fibrillation (pAF) can be performed under general anesthesia (GA) or moderate sedation (MS). Our objective was to compare the effectiveness, safety, procedure duration, and time spent in electrophysiology (EP) laboratory CBA GA MS.Patients undergoing a first pAF were identified. Patients received either administered by an anesthesiologist MS with midazolam fentanyl EP staff. Total (sum of nonprocedure time); fluoroscopy time; freedom from...
While several studies have evaluated predictors for atrial fibrillation (AF) recurrence following catheter ablation, there are limited data specific to cryoballoon ablation (CBA).We analyzed a prospective registry of patients at single institution who underwent CBA. Recurrence AF (RAF) was defined as by 12-month follow-up, excluding the 3-month blanking period. Univariate analysis performed evaluate RAF. Receiver operating characteristic used compare and performance various risk scores...
Abstract Epilepsy treatment is challenging because of multiple impediments like lack efficacy monotherapy, adverse drug reactions, and different comorbidities. Add‐on therapy to first‐line antiepileptics may be the option overcome therapeutic hurdles. The present randomized, double‐blind, add‐on placebo‐controlled clinical trial was conducted evaluate effect melatonin in generalized epilepsy with onset motor seizure adults. control group ( n = 52) received placebo, test (3 mg/day) valproate...
Background Prophylactic use of direct oral anticoagulants for recurrent stroke prevention in patients with embolic strokes undetermined source is currently being investigated. It uncertain whether the bleeding risks associated prophylactic will outweigh any benefit who lack underlying atrial fibrillation. Methods We determined proportion cryptogenic CRYSTAL fibrillation trial met inclusion criteria NAVIGATE and RE-SPECT trials their incidence. Both impose requirements on age, modified Rankin...
Standard two-dimensional (2D), phased-array intracardiac echocardiography (ICE) is routinely used to guide interventional electrophysiology (EP) procedures. A novel four-dimensional (4D) ICE catheter (VeriSight Pro, Philips) can obtain 2D and three-dimensional (3D) volumetric images cine-videos in real-time (4D). The purpose of this study was determine the early feasibility safety 4D during EP procedures.The placed from femoral vein ten patients into various cardiac chambers procedures...
ABSTRACT Introduction The subcutaneous implantable cardioverter defibrillator (S‐ICD) is an alternative to a transvenous ICD in patients who meet the criteria for implantation without concurrent need cardiac pacing. objective of this study examine rates and indications S‐ICD removal extraction. Methods A retrospective analysis all underwent between 2010 2022 at single multihospital healthcare system was performed. primary endpoint or Patient device characteristics were abstracted from...
Cardiac resynchronization therapy (CRT) has shown a significant clinical benefit over right ventricular pacing in patients with left dysfunction and high requirement.1 Traditionally, CRT relied on coronary sinus (CS) lead placement through the use of fluoroscopy venography. Three-dimensional (3D) electroanatomic mapping been used as an alternative technique for CS placement.2 Recently, permanent His bundle emerged another to achieve via near physiologic activation both ventricles native...
Abstract Introduction Obesity is an established risk factor for recurrent atrial fibrillation (AF) after ablation. The impact of pre‐procedure weight changes on freedom from AF (FFAF) ablation in obese and nonobese patients unknown. Methods A single‐center retrospective cohort study undergoing pulmonary vein isolation was performed. Before ablation, all candidates were encouraged to adopt healthy lifestyle habits according American Heart Association guidelines, including loss, by their...
Abstract Introduction Focal impulse and rotor modulation (FIRM) ablation can be used to target nonpulmonary vein (PV) sources of atrial fibrillation (AF). No published studies have compared freedom from (FFAF) after pulmonary reisolation (PVRI) plus FIRM PVRI alone in patients with reconnected PVs undergoing repeat ablation. Methods A 3:1 matched retrospective cohort study was performed on 21 recurrent AF PV reconnection who underwent FIRM‐guided 63 treated at a single institution. All the...