A5066809390- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- ECG Monitoring and Analysis
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Health and Mental Health
- Cardiomyopathy and Myosin Studies
- HIV/AIDS drug development and treatment
- Methemoglobinemia and Tumor Lysis Syndrome
- Cardiovascular Issues in Pregnancy
- Neurological disorders and treatments
- Statistical Methods in Clinical Trials
- Heme Oxygenase-1 and Carbon Monoxide
- Electromagnetic Fields and Biological Effects
- Social Media in Health Education
- HIV Research and Treatment
- Cardiac Structural Anomalies and Repair
- Meta-analysis and systematic reviews
- Cardiovascular Disease and Adiposity
- HIV-related health complications and treatments
Northwestern University
2013-2024
Northwestern Medicine
2023
Northwestern University
2022
University Medical Center
2018
Emory University
2014-2017
The University of Texas Southwestern Medical Center
2016
King's College London
2016
Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and associated worse prognosis. Young women a previous infarction (MI), group unexplained higher mortality than men of comparable age, have shown elevated rates MSIMI, but the mechanisms are unknown.
Standard two-dimensional (2D), phased-array intracardiac echocardiography (ICE) is routinely used to guide interventional electrophysiology (EP) procedures. A novel four-dimensional (4D) ICE catheter (VeriSight Pro, Philips) can obtain 2D and three-dimensional (3D) volumetric images cine-videos in real-time (4D). The purpose of this study was determine the early feasibility safety 4D during EP procedures.The placed from femoral vein ten patients into various cardiac chambers procedures...
Abstract Introduction Oral sotalol initiation requires a multiple‐day, inpatient admission to monitor for QT prolongation during loading. A 1‐day intravenous (IV) loading protocol was approved by the United States Food and Drug Administration in March 2020, but limited data on clinical use administration currently exists. This study describes implementation of an IV within integrated health system, provides initial efficacy safety outcomes, examines length stay (LOS) compared with oral...
Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise.To evaluate feasibility, process, and outcomes of a reproduction analysis THERMOCOOL SMARTTOUCH Catheter Treatment Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial using shared data.A SMART-AF was performed data sets, dictionary, case report file, statistical plan from original accessed through Yale Open Access Project SAS Clinical Trials Transparency platform. multicenter,...
Atrial Flutter (AFL) is a supraventricular tachyarrhythmia typically arising from macroreentry circuit that can have variable atrial anatomy. It often treated by catheter ablation, the success of which depends upon correct determination electroanatomic circuit, generally through invasive electrophysiological (EP) study. We hypothesized machine learning (ML) methods applied to diagnostic 12-lead surface electrocardiogram (ECG) could determine specific prior any EP study.The ECGs were reduced...
Abstract Introduction Esophageal thermal injury (ETI) is a well‐recognized complication of atrial fibrillation (AF) ablation. Previous studies have demonstrated that direct esophageal cooling reduces ETI during radiofrequency AF The purpose this study was to evaluate the use an warming device prevent cryoballoon ablation (CBA) for AF. Methods This prospective, double‐blinded enrolled 42 patients with symptomatic undergoing CBA. Patients were randomized treatment group (42°C) using...
A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, patient received application of endobronchial lidocaine (4% gel). Within 2 h intubation, developed worsening hypoxia, and investigation arterial blood gasses revealed a pH 7.21, carbon dioxide partial pressure (PaCO2) 3.3 kPa, oxygen (PaO2) 55.1 measured saturation 49%. Co-oximetry this sample returned methemoglobin level 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg)...
Coronavirus disease 2019 (COVID-19) is a global pandemic increasingly encountered in the clinical setting. It typically manifests as respiratory illness, although cardiac involvement common and portends worse prognosis. We present case of 56-year-old male admitted with COVID-19 fulminant myocarditis cardiogenic shock. discuss important aspects multidisciplinary interventional care involved treating shock well likely mechanisms of, potential treatment for, myocarditis. The various pathways...
Background: The electronic medical record contains a wealth of information buried in free text. We created natural language processing algorithm to identify patients with atrial fibrillation (AF) using text alone. Methods and Results: 3 data sets from at least one AF billing code 2010 2017: training set (n=886), an internal validation site no. 1 (n=285), external 2 (n=276). A team clinicians reviewed adjudicated as present or absent, which served the reference standard. trained 54 algorithms...
Introduction: Multiple randomized clinical trials have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP1) receptor agonists reduce the risk of cardiovascular events mortality in patients with type diabetes (T2D) disease (CVD). In order to inform implementation strategies, we sought describe prescribing trends among T2D practice. Methods: We developed a cohort using validated computable phenotype from electronic data warehouse large academic health...
Introduction: The subcutaneous implantable cardioverter defibrillator (SICD) serves as an alternative to traditional transvenous defibrillators in patients who meet criteria for ICD implantation without concurrent need cardiac pacing. Data on SICD extraction is limited. This study examines the rates of extraction. Methods: A retrospective all underwent between 2010 and 2022 at a single healthcare system was performed. primary endpoint rate Results: total 402 (67.4% male; 48.5 ± 14.4 years...
Background: Mental stress induced myocardial ischemia (MSIMI) is linked to increased risk of adverse cardiovascular outcomes, but its mechanisms are thought be different from those conventional stress-induced (CSIMI). Specifically, whether MSIMI associated with more severe underlying obstructive coronary artery disease (CAD) unclear. We investigated the association between angiographically-defined CAD severity and both CSIMI a hypothesis that, will CSIMI, not MSIMI. Methods: A total 273...