A5012459189- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Elasticity and Material Modeling
- Coronary Interventions and Diagnostics
- Color Science and Applications
- Pelvic floor disorders treatments
- Bone fractures and treatments
- Cardiovascular Health and Disease Prevention
- Optical Coherence Tomography Applications
- Industrial Vision Systems and Defect Detection
- Pelvic and Acetabular Injuries
- Cardiovascular Disease and Adiposity
- Photoacoustic and Ultrasonic Imaging
- Maternal and fetal healthcare
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Spectroscopy and Chemometric Analyses
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Acute Myocardial Infarction Research
- Ectopic Pregnancy Diagnosis and Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Textile materials and evaluations
- Frailty in Older Adults
- Bariatric Surgery and Outcomes
Columbia University
2020-2024
Beijing Institute of Graphic Communication
2021-2024
Mount Sinai Hospital
2018
St. Luke's Hospital
2018
Maimonides Medical Center
2018
Icahn School of Medicine at Mount Sinai
2018
Mount Sinai Hospital
2018
Emory University
2015-2017
Despite the advancements in skin bioengineering, 3D constructs are still produced as flat tissues with open edges, disregarding fully enclosed geometry of human skin. Therefore, they do not effectively cover anatomically complex body sites, e.g., hands. Here, we challenge prevailing paradigm by engineering a tissue that can be shaped after part and seamlessly transplanted biological clothing. Our wearable edgeless (WESCs) show enhanced dermal extracellular matrix (ECM) deposition mechanical...
Abstract Cervical remodeling is critical for a healthy pregnancy. Premature tissue changes can lead to preterm birth (PTB), and the absence of post-term birth, causing significant morbidity. Comprehensive characterization cervical material properties necessary uncover mechanisms behind abnormal softening. Quantifying during gestation challenging in humans. Thus, nonhuman primate (NHP) model employed this study. In study, samples were collected from Rhesus macaques before pregnancy at three...
Tissue mechanics is central to pregnancy, during which maternal anatomic structures undergo continuous remodeling serve a dual function first protect the fetus in utero while it develops and then facilitate its passage out. In this study of normal pregnancy using biomechanical solid modeling, we used standard clinical ultrasound images obtain measurements structural dimensions gravid uterus cervix throughout gestation. 2-dimensional were acquired from 30 pregnant subjects supine standing...
Automatic quantification and visualization of 3-D collagen fiber architecture using Optical Coherence Tomography (OCT) has previously relied on polarization information and/or prior knowledge tissue-specific architecture. This study explores image processing, enhancement, segmentation, detection algorithms to map from OCT images alone. mapping, histogram analysis, tractography revealed groupings macro-organization unseen in uterine tissue samples. We applied our method centimeter-scale...
Birthing mechanics are poorly understood, though many injuries during childbirth mechanical, like fetal and maternal tissue damage. Several biomechanical simulation models of parturition have been proposed to investigate birth, but do not include the uterus. Additionally, most solid rely on segmenting anatomical structures from clinical images generate patient geometry, which can be time-consuming. This work presents two new parametric modeling methods for generating patient-specific,...
The uterus has critical biomechanical functions in pregnancy and undergoes dramatic material growth remodeling from implantation to parturition. intrinsic properties of the human how they evolve are poorly understood. To address this knowledge gap assess heterogeneity these tissues, time-dependent all uterine layers were measured with nanoindentation. endometrium-decidua layer was found be least stiff, most viscous, permeable nonpregnant third-trimester pregnant tissues. In pregnancy,...
In spectral-based ink content measurement, improving the accuracy of spectral collection system and reducing algorithm complexity measurement model are important aspects research. This study designs a with an M-type Czerny–Turner optical path structure, uses third-order polynomial fitting method for calibration analysis, collects standard color card denoises it through Savitzky–Golay convolution smoothing, establishes functional relationship between logarithm content. Uninformative Variable...
ABSTRACT The uterus is central to the establishment, maintenance, and delivery of a healthy pregnancy. Biomechanics an important contributor pregnancy success, alterations normal uterine biomechanical functions can contribute array obstetric pathologies. Few studies have characterized passive mechanical properties gravid human uterus, ethical limitations largely prevented investigation mid-gestation periods. To address this key knowledge gap, study seeks characterize structural,...
High resolution collagen fiber organization is a prime metric for evaluating uterine health. In this research, computational methods orientation analysis of registered and stitched ultra-large OCT volumes were developed.
Background: Mental stress induced myocardial ischemia (MSIMI) is linked to increased risk of adverse cardiovascular outcomes, but its mechanisms are thought be different from those conventional stress-induced (CSIMI). Specifically, whether MSIMI associated with more severe underlying obstructive coronary artery disease (CAD) unclear. We investigated the association between angiographically-defined CAD severity and both CSIMI a hypothesis that, will CSIMI, not MSIMI. Methods: A total 273...