A5091060974- Cardiac Health and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes Treatment and Management
- Cardiovascular Health and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Cardiovascular Health and Disease Prevention
- Systemic Sclerosis and Related Diseases
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Intensive Care Unit Cognitive Disorders
- Telomeres, Telomerase, and Senescence
- Cerebrovascular and Carotid Artery Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiovascular Disease and Adiposity
- Gastric Cancer Management and Outcomes
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Treatment
- Pancreatic and Hepatic Oncology Research
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
Boehringer Ingelheim (United States)
2019-2024
Institute of Engineering
2024
Boehringer Ingelheim (Germany)
2024
Cleveland Clinic
2021
Humana (United States)
2021
Emory University
2013-2019
Bridge University
2019
University of Alberta
2014-2017
Veterans Health Administration
2017
Tulane University
2016
Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and associated worse prognosis. Young women a previous infarction (MI), group unexplained higher mortality than men of comparable age, have shown elevated rates MSIMI, but the mechanisms are unknown.
Background Young women with coronary heart disease have high rates of depression and a higher risk adverse events than men similar age. Whether has prognostic value in this group older is not known. Our objective was to assess whether young associated artery ( CAD ) outcomes compared similarly aged women. Methods Results We examined 3237 patients undergoing angiography for evaluation followed them 2.9 years (median). Depressive symptoms were assessed the Patient Health Questionnaire PHQ )‐9,...
Objectives Emotional stress may disproportionally affect young women with ischemic heart disease. We sought to examine whether mental stress–induced myocardial ischemia (MSIMI), but not exercise-induced ischemia, is more common in previous infarction (MI) than men. Methods studied 98 post-MI patients (49 and 49 men) aged 38 60 years. Women men were matched for age, MI type, months since MI. Patients underwent technetium-99m sestamibi perfusion imaging at rest, after stress,...
Background Emerging data suggest that young women with coronary heart disease ( CHD ) are disproportionally vulnerable to the adverse cardiovascular effects of psychological stress. We hypothesized younger, but not older, stable more likely than their male peers develop mental stress‐induced myocardial ischemia MSIMI ). Methods and Results studied 686 patients (191 women) Patients underwent 99m Tc‐sestamibi perfusion imaging at rest both (speech task) conventional (exercise/pharmacological)...
Background Higher symptom levels of a variety measures emotional distress have been associated with cardiovascular disease ( CVD ), especially among women. Here, our goal was to investigate the association between composite measure psychological and incident events. Methods Results In prospective cohort study, we assessed 662 individuals (28% women; 30% blacks) stable coronary artery disease. We used score derived through summation Z-transformed scales (depression, posttraumatic stress,...
Leukocyte telomere length (LTL) is a biological marker of aging, and shorter LTL associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as mechanism. Bone marrow-derived circulating progenitor cells are involved in tissue repair regeneration.Main objective this study was to examine the relationship between their impact on outcomes.We measured by quantitative polymerase chain reaction 566 outpatients (age: 63±9 years; 76% men) coronary artery disease....
Objective— To investigate sex-specific vascular mechanisms for mental stress-induced myocardial ischemia (MSIMI). Approach and Results— Baseline data from a prospective cohort study of 678 patients with coronary artery disease underwent perfusion imaging before during public speaking stressor. The rate-pressure product response was calculated as the difference between maximum value speech minus minimum rest. Peripheral vasoconstriction by peripheral arterial tonometry ratio pulse wave...
Depressive symptoms are associated with lower heart rate variability (HRV), an index of autonomic dysregulation, but the direction association remains unclear.To investigate temporal between depression and HRV.A longitudinal, cross-lagged twin difference study, baseline assessments from March 2002 to 2006 (visit 1) a 7-year follow-up 2) at academic research center participants recruited national registry. Twins (n = 166) Vietnam Era Twin Registry, who served in US military during War, were...
Objectives Depression is an adverse prognostic factor after acute myocardial infarction (MI), and increased propensity toward emotionally-driven ischemia may play a role. We aimed to examine the association between depressive symptoms mental stress-induced in young survivors of MI. Methods studied 98 patients (49 women 49 men) age 38–60 years who were hospitalized for MI previous 6 months. Patients underwent perfusion imaging at rest, stress (speech task), exercise or pharmacological stress....
Abstract The influence of acute psychological stress on cardiovascular disease is an emerging public health concern. Identification brain mechanisms underlying this may aid in the discovery possible treatments. Acute induce arteriolar vasoconstriction and reduce blood flow to vital organs. We hypothesized that functional changes regions involved with memory autonomic/emotional regulation are implicated vasoconstrictive response, including medial prefrontal cortex (anterior cingulate),...
Abstract Aim To estimate the cost‐effectiveness of sequential addition empagliflozin versus sitagliptin after metformin in patients with type 2 diabetes (T2D) or without cardiovascular disease (CVD) from perspective US healthcare payer. Methods An individual simulation model predicted lifetime diabetes‐related complications, using UKPDS‐OM2 equations CVD, and EMPA‐REG OUTCOME CVD. Additional US‐based sources informed inputs for population characteristics, adverse events, non‐CV death,...
Background: Many patients with coronary artery disease (CAD) are routinely referred for surveillance stress testing despite recommendations against it. Objective: To determine whether low levels of resting high-sensitivity cardiac troponin I (hs-cTnI) can identify persons without inducible myocardial ischemia. Design: Observational study. Setting: A university-affiliated hospital network. Patients: Persons stable CAD: 589 in the derivation group and 118 validation cohort. Measurements:...
ABSTRACT Objective Mental stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease (CAD). The link between an integrated measure of chronic psychosocial distress and mental ischemia, whether it differs by sex, has not been examined before. Methods We used latent class analysis to derive composite integrating scales depression, posttraumatic stress, anxiety, anger, hostility, perceived stress 665 individuals stable CAD. Participants underwent...
To estimate the cost-effectiveness of sequential use sodium-glucose co-transporter-2 inhibitor empagliflozin and glucagon-like peptide-1 receptor agonist liraglutide after metformin in patients with type 2 diabetes (T2D) from US payer perspective.An economic simulation model a lifetime horizon was developed to T2D-related complications (including cardiovascular [CV] death, myocardial infarction, stroke, renal outcomes) using EMPA-REG OUTCOME data or UK Prospective Diabetes Study risk...
BackgroundThe response of progenitor cells (PCs) to transient myocardial ischemia in patients with coronary artery disease remains unknown. We aimed investigate the PC exercise-induced (ExMI) and compare it flow mismatch during pharmacological stress testing. Methods ResultsA total 356 stable underwent 99mTc-sestamibi perfusion imaging exercise (69%) or (31%). CD34