A5107048480- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Microtubule and mitosis dynamics
- Elasticity and Material Modeling
- Photoreceptor and optogenetics research
- Cellular Mechanics and Interactions
- Legionella and Acanthamoeba research
- Radiopharmaceutical Chemistry and Applications
- Cellular transport and secretion
- Proteoglycans and glycosaminoglycans research
- Vibrio bacteria research studies
- Neonatal Respiratory Health Research
- HER2/EGFR in Cancer Research
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial Inactivation Methods
- Clostridium difficile and Clostridium perfringens research
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging Techniques and Applications
- Neuroscience and Neural Engineering
- Neurogenetic and Muscular Disorders Research
- Connective tissue disorders research
- Gut microbiota and health
University of Otago
2023-2024
Kettering University
2021-2024
Memorial Sloan Kettering Cancer Center
2021-2024
Duke-NUS Medical School
2024
Loma Linda University
2024
Loma Linda University Medical Center
2024
Geisinger Medical Center
2024
Columbia University
2021-2023
University of Washington
2018-2022
Harvard University
2022
Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation unclear. In a cohort 174 patients who underwent allo-HCT, we demonstrate that diverse intestinal microbiome early after allo-HCT an increased number innate-like mucosal-associated invariant T (MAIT) cells, which are turn overall survival and less acute graft-versus-host disease (aGVHD). Immune profiling conventional...
T cells are the central drivers of many inflammatory diseases, but repertoire tissue-resident at sites pathology in human organs remains poorly understood. We examined site-specificity cell receptor (TCR) repertoires across tissues (5 to 18 per patient) prospectively collected autopsies patients with and without graft-versus-host disease (GVHD), a potentially lethal tissue-targeting complication allogeneic hematopoietic transplantation, mouse models GVHD. Anatomic similarity between was key...
The analysis of neural circuits has been revolutionized by optogenetic methods. Light-gated chloride-conducting anion channelrhodopsins (ACRs)-recently emerged as powerful neuron inhibitors. For cells or sub-neuronal compartments with high intracellular chloride concentrations, however, a conductance can have instead an activating effect. recently discovered light-gated, potassium-conducting, kalium (KCRs) might serve alternative in these situations, potentially broad application. As yet,...
The food-borne pathogen
<sec> <title>UNSTRUCTURED</title> Alcohol consumption is socially accepted in Australia and places where alcohol not served are rare. However, remains a major public health concern. Since COVID-19, has increased even more, increasing non-communicable disease risks, social harms economic costs. The engrained nature of adds complexity to designing successful reduction approaches. Rather than implementing another intervention, we will undertake natural experiment on the 'sober curious'...
Vibrio vulnificus, a waterborne and foodborne pathogen, lives in estuarine environments thrives warmer waters.V. vulnificus can infect open wounds through contact with salt water, brackish or raw seafood; infections also occur after consuming undercooked seafood.In the United States, 150-200 V. are reported to CDC annually, approximately 20% of which fatal.*During June-August 2023, widespread heat waves above-average sea surface temperatures occurred States (1).During July-August public...
The signaling pathways by which mechanical forces modulate fetal lung development remain largely unknown. In the present study, we tested hypothesis that strain-induced type II cell differentiation is mediated via cAMP pathway. Freshly isolated E19 epithelial cells were cultured on collagen-coated silastic membranes and exposed to strain for varying intervals, simulate during development. Unstretched samples used as controls. Mechanical activated heterotrimeric G-protein alpha(s) subunit,...
Abstract Introduction and Aims There are no medications approved for the treatment of methamphetamine withdrawal. Wake‐promoting agent modafinil has recently been proposed as a viable option. This paper reports on results pilot study that tested feasibility in an inpatient withdrawal setting during acute Design Methods In double‐blind, randomised, placebo‐controlled study, 19 dependent participants received ( n = 9) or placebo 10) daily 7 days (200 mg first 5 100 6 7). Primary outcomes were...
Naegleria fowleri is a thermophilic ameba found in freshwater that causes primary amebic meningoencephalitis (PAM) when it enters the nose and migrates to brain. Patient exposure water containing typically occurs warm lakes ponds during recreational activities. In June 2016, an 18-year-old woman died of PAM after traveling North Carolina, where she participated rafting on artificial whitewater river. We conducted epidemiologic environmental investigation determine led death this patient. The...
Abstract Pre-leukemic stem cells (pre-LSCs) give rise to leukemic through acquisition of additional gene mutations and are an important source relapse following chemotherapy. We postulated that cell-cycle kinetics pre-LSCs may be determinant clonal evolution therapeutic resistance. Using a doxycycline-inducible H2B-GFP transgene in mouse model T-cell acute lymphoblastic leukemia study cell cycle vivo, we show self-renewal, resistance limited rare population with restricted cycle....
Metazoan cells can generate unequal-sized sibling during cell division. This form of asymmetric division depends on spindle geometry and Myosin distribution, but the underlying mechanics are unclear. Here, we use atomic force microscopy live imaging to elucidate biophysical forces involved in establishment physical asymmetry Drosophila neural stem cells. We show that initial apical cortical expansion is driven by hydrostatic pressure, peaking shortly after anaphase onset, enabled a relief...
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves implantation a device battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. modulates neuronal activities in nucleus improving physiological responses as long an electric discharge above threshold can be achieved. In effort improve performance device, size, implementation cost, power...
We investigated an outbreak initially attributed to norovirus; however, Clostridium perfringens toxicoinfection was subsequently confirmed. C. is underrecognized but frequently observed cause of food-borne disease outbreaks. This investigation illustrates the importance considering epidemiologic and laboratory data together when evaluating potential etiologic agents that might require unique control measures.
Purpose: The purpose of this study was to evaluate the labor characteristics and maternal/perinatal consequences following indicated induction labor.Methods: This retrospective examined all inductions over 24 months at two institutions evaluated mode delivery (vaginal versus cesarean) as well a comprehensive list outcomes.Results: There were 1577 with 1097/1577 (69.6%) delivering vaginally. Women cesarean had lower parity (p < (0).0001) Bishop's score (0).0001), higher body mass indices =...
Intracellular bacterial pathogens remodel the plasma membrane of eukaryotic cells in order to establish infection. A common and well-studied mechanism remodelling involves stimulation polymerization host actin cytoskeleton. Here, we discuss recent results showing that several also exploit vesicular trafficking pathway 'polarized exocytosis' expand reshape specific regions during Polarized exocytosis is mediated by an evolutionarily conserved octameric protein complex termed exocyst. We...