A5067128307- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Nanowire Synthesis and Applications
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Insect Resistance and Genetics
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Transgenic Plants and Applications
City Of Hope National Medical Center
2024
Memorial Sloan Kettering Cancer Center
2020-2024
City of Hope
2024
Kettering University
2023-2024
California University of Pennsylvania
2024
University of Freiburg
2020
University Medical Center Freiburg
2013-2020
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML allo-HCT exhibited reduced glycolysis and interferon-γ production. Functional studies in multiple mouse models showed leukemia-derived lactic acid (LA) interfered proliferation. Mechanistically, LA intracellular pH cells, led to lower transcription glycolysis-related enzymes, decreased activity essential metabolic...
Abstract Resistance to chimeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms including antigen-loss escape and tumor-induced immune suppression. Expression of CARs may overcome multi-antigen-loss escape. Similarly, expression switch receptors that convert inhibitory checkpoint signals into positive costimulatory enhance CAR activity in the tumor microenvironment. Engineering features one product, however, is limited by transgene packaging constraints current...