Annelie Clurman
A5008311120- Gut microbiota and health
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- Clinical Nutrition and Gastroenterology
- Polyomavirus and related diseases
- Microscopic Colitis
- CAR-T cell therapy research
- Probiotics and Fermented Foods
- Salivary Gland Disorders and Functions
- Childhood Cancer Survivors' Quality of Life
- Biochemical Analysis and Sensing Techniques
- Diabetic Foot Ulcer Assessment and Management
- Silymarin and Mushroom Poisoning
- T-cell and B-cell Immunology
- Infant Nutrition and Health
- Pancreatic and Hepatic Oncology Research
- Ginseng Biological Effects and Applications
- Pancreatitis Pathology and Treatment
- Palliative Care and End-of-Life Issues
Memorial Sloan Kettering Cancer Center
2018-2024
Centre Hospitalier Régional et Universitaire de Nancy
2023
Institute Cancer De La Loire Lucien Neuwirth
2023
Hôpital Universitaire Dupuytren
2023
Centre Hospitalier Universitaire de Toulouse
2023
Kettering University
2019-2022
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Abstract Patients with multiple myeloma (MM) who achieve minimal residual disease (MRD) negativity after upfront treatment have superior outcomes compared those remain MRD+. Recently, associations been shown between specific commensal microbes and development of plasma cell disorders. Here, we report the association intestinal microbiota composition outcome in MM. Microbiota fecal samples collected from 34 MM patients induction therapy at time flow cytometry–based bone marrow MRD testing was...
Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation unclear. In a cohort 174 patients who underwent allo-HCT, we demonstrate that diverse intestinal microbiome early after allo-HCT an increased number innate-like mucosal-associated invariant T (MAIT) cells, which are turn overall survival and less acute graft-versus-host disease (aGVHD). Immune profiling conventional...
Abstract Purpose: The gut microbiota is subject to multiple insults in allogeneic hematopoietic cell transplantation (allo-HCT) recipients. We hypothesized that preparative conditioning regimens contribute perturbation allo-HCT. Experimental Design: This was a retrospective study evaluated the relationship between exposure 1,188 allo-HCT recipients and microbiome. Stool samples collected from 20 days before up 30 after were profiled using 16S rRNA sequencing. Microbiota injury quantified by...
Intestinal microbiota composition is implicated in several diseases; understanding the factors that influence it are key to elucidating host-commensal interactions and designing microbiome-targeted therapies. We quantified how diet influences microbiome dynamics hospitalized patients. recorded 9,419 meals consumed by 173 patients undergoing hematopoietic cell transplantation profiled 1,009 longitudinally collected stool samples from 158 of them. Caloric intake was correlated with fecal...
Cellular therapy with chimeric antigen receptor (CAR) T cells has fundamentally changed the treatment of many cancers. Unfortunately, not all patients who receive this have a favorable response. Additionally, may develop toxicity due to cytokine release syndrome (CRS) or neurotoxicity. We hypothesized that composition intestinal microbiota prior CAR cell infusion is correlated efficacy and toxicity.We collected fecal samples from recipients at Memorial Sloan Kettering Cancer Center (MSKCC)...