Lauren Bohannon
A5076674899- Hematopoietic Stem Cell Transplantation
- Gut microbiota and health
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Cancer survivorship and care
- Frailty in Older Adults
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Childhood Cancer Survivors' Quality of Life
- Health Systems, Economic Evaluations, Quality of Life
- Acute Lymphoblastic Leukemia research
- Economic and Financial Impacts of Cancer
- Cancer-related cognitive impairment studies
- Ginseng Biological Effects and Applications
- Anesthesia and Sedative Agents
- Histone Deacetylase Inhibitors Research
- Polyomavirus and related diseases
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Renal Transplantation Outcomes and Treatments
- Infant Health and Development
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
Duke University
2019-2025
Duke Medical Center
2019-2024
Duke University Hospital
2023
Levine Cancer Institute
2017-2023
Duke Cancer Institute
2020
Carolinas Healthcare System
2017
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
The COVID-19 pandemic continues to pose unprecedented challenges worldwide health. While vaccines are effective, additional strategies mitigate the spread/severity of continue be needed. Emerging evidence suggests susceptibility respiratory tract infections in healthy subjects can reduced by probiotic interventions; thus, probiotics may a low-risk, low-cost, and easily implementable modality reduce risk COVID-19.
Certain anaerobic bacteria are important for maintenance of gut barrier integrity and immune tolerance may influence the risk graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a single-center retrospective cohort study HSCT recipients to evaluate associations between receipt antibiotics with an spectrum activity GVHD outcomes. identified 1214 children adults who developed febrile neutropenia 7 days before 28 compared mortality...
The COVID-19 pandemic has proven to be an unprecedented challenge worldwide health, and strategies mitigate the spread severity of infection are urgently needed. Emerging evidence suggests that composition gut microbiome modification microbial ecology via probiotics can affect susceptibility a wide range infections, including respiratory tract infections. In this study, we aim evaluate effects probiotic Lactobacillus rhamnosus GG (LGG) versus placebo on status in subjects with household...
STRUCTURED ABSTRACT Importance The COVID-19 pandemic continues to pose unprecedented challenges worldwide health. While vaccines are effective, supplemental strategies mitigate the spread and severity of urgently needed. Emerging evidence suggests susceptibility infections, including respiratory tract may be reduced by probiotic interventions; therefore, probiotics a low-risk, widely implementable modality risk disease, particularly in areas with low vaccine availability and/or uptake....
Gut dysbiosis is linked to mortality and the development of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), but impact cutaneous remains unexplored. We performed a pilot observational study obtained retroauricular forearm skin swabs from 12 adult patients prior conditioning chemotherapy/radiation, at 1-week, 1-month 3-months allogeneic HSCT, shotgun metagenomic sequencing. The microbiome among HSCT was enriched for gram-negative bacteria such as E coli...
Abstract Ionizing-radiation causes acute radiation syndrome leading to hematopoietic, gastrointestinal and cerebrovascular injuries. Substantial federal efforts have been made develop therapeutic radioprotectants for routine clinical use, however it remains a long-standing unresolved problem. We investigated population of mice that recovered from high-dose live normal lifespans. These elite-survivors harbored distinct gut microbiota developed post-radiation protected against...
Hematopoietic stem cell transplantation (HCT) is a curative treatment option for patients with hematologic conditions but presents many complications that must be managed as complex, chronic condition. Mobile health applications (mHealth apps) may permit tracking of symptoms in HCT. In seeking strategies to manage the complexities HCT, our team collaborated Sicklesoft, Inc., develop an mHealth app specifically HCT allow daily evaluation patient health, Technology Recordings better Understand...
Allogeneic hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for both malignant and nonmalignant hematologic diseases; however, reported rates of treatment-related mortality approach 30%. Outcomes are worse in patients who begin HCT with functional impairments. To detect such impairments, geriatric assessment (GA) recommended adults age ≥65 years. Younger candidates also may be impaired because chemotherapy regimens pre-HCT. Therefore, we hypothesized that GA...
Patients undergoing allogeneic (allo) and autologous (auto) hematopoietic cell transplantation (HCT) require extensive hospitalizations or daily clinic visits for the duration of their transplantation. Home HCT, wherein patients live at home providers make trips to patient's residence perform assessments deliver any necessary interventions, may enhance patient quality life improve outcomes. We conducted first study HCT in United States evaluate this model US healthcare setting determine...
Introduction Although allogeneic hematopoietic stem cell transplantation (HCT) can be a curative therapy for hematologic disorders, it is associated with treatment-related complications and losses in cardiorespiratory fitness physical function. High-intensity interval training (HIIT) may practical way to rapidly improve function the weeks prior HCT. The primary aim of this study was assess feasibility implementing pre-HCT home-based HIIT intervention. secondary evaluate pre post changes...
PURPOSE We investigated the prevalence of financial toxicity in a population undergoing hematopoietic cell transplantation (HCT) evaluation and measured its impact on post-transplant clinical health-related quality-of-life outcomes. MATERIALS AND METHODS This was prospective study patients for allogeneic HCT between January 1, 2018, September 23, 2020, at large academic medical center. Financial health via baseline survey comprehensive score toxicity-functional assessment chronic illness...
Abstract Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown improve clinical compared chemotherapy alone. This is the first trial reporting on broad correlative studies define immunologic mechanisms action in older patients. newly diagnosed were eligible for enrollment, receiving induction cytarabine (100...
Bloodstream infections (BSIs) occur in 20% to 45% of inpatient autologous and allogeneic hematopoietic cell transplant (HCT) patients. Daily bathing with the antiseptic chlorhexidine gluconate (CHG) has been shown reduce incidence BSIs critically ill patients, although very few studies include HCT patients or have evaluated impact compliance on effectiveness. We conducted a prospective cohort study historical controls assess CHG rate gut microbiota composition among adults undergoing at Duke...
Life expectancy for long-term survivors of allogeneic hematopoietic stem cell transplantation (alloHSCT), defined as those living ≥5 years post-transplantation, is significantly lower compared with that the age-matched general population despite a relatively low primary disease relapse rate at >2 post-transplantation. Among several factors, patient sex increasingly recognized prognostic indicator survival. We examined influence and donor-recipient matching on overall survival (OS) in...