A5022742038- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Garlic and Onion Studies
- RNA regulation and disease
- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Cancer-related Molecular Pathways
- Reconstructive Facial Surgery Techniques
- Acute Lymphoblastic Leukemia research
- Bioactive Compounds and Antitumor Agents
- interferon and immune responses
- Nanowire Synthesis and Applications
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Prenatal Substance Exposure Effects
- Acute Myeloid Leukemia Research
- Global Cancer Incidence and Screening
- Family and Patient Care in Intensive Care Units
- Synthesis and Biological Evaluation
- Reproductive System and Pregnancy
University of North Carolina at Chapel Hill
2023-2024
The University of Sydney
2022-2023
Duke University
2022
World Health Organization - Pakistan
2021
Duke Medical Center
2020-2021
Baylor College of Medicine
2016-2020
Houston Methodist
2016-2020
Methodist Hospital
2020
Texas Children's Hospital
2016-2020
Michael E. DeBakey VA Medical Center
2019
Glioblastoma is the most aggressive primary brain tumor in humans and virtually incurable with conventional therapies. Chimeric antigen receptor (CAR) T cell therapy targeting glioblastoma EphA2 an attractive approach to improve outcomes because expressed highly but only at low levels normal tissue. Building upon our previous findings this area, we generated evaluated a panel of EphA2-specific CARs. We demonstrate here that cells expressing CD28.ζ 41BB.ζ CARs short spacers had similar...
Oncolytic virotherapy has been tested in numerous early phase clinical studies. However, the antitumor activity of oncolytic viruses thus far limited. Numerous strategies are being explored to enhance their by activating adaptive arm immune system. We reasoned that it might also be possible engineer redirect tumor-associated macrophages tumor cells for therapeutic benefit. engineered an vaccinia virus (VV) disrupt CD47/SIRPα interaction expressing a chimeric molecule consists ectodomain...
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by poikiloderma, small stature, sparse hair, skeletal abnormalities, increased risk of osteosarcoma, and decreased bone mass. To date, there has not been comprehensive evaluation the prevalence extent metabolic disease in RTS. Furthermore, mechanisms that result this phenotype are largely unknown. In report, we provide detailed 29 individuals with RTS respect to their status including mineral density,...
Life expectancy for long-term survivors of allogeneic hematopoietic stem cell transplantation (alloHSCT), defined as those living ≥5 years post-transplantation, is significantly lower compared with that the age-matched general population despite a relatively low primary disease relapse rate at >2 post-transplantation. Among several factors, patient sex increasingly recognized prognostic indicator survival. We examined influence and donor-recipient matching on overall survival (OS) in...
Abstract Background Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated utility ICGA decision to delay postmastectomy its predictive power for Methods Single-institution retrospective study implant-based reconstructions following mastectomy using from 2015 2021. A was made proceed immediate or based on clinical assessment perfusion analysis. Incidence complications delayed...
Carcinoid brain metastases are extremely rare and associated with a poor prognosis. Treatment options variable, ranging from surgery, radiation, or chemotherapy alone combined. We report on case of rectal carcinoid metastatic to the cerebellum review chemotherapeutic regimens for tumor treatment, focusing potential role temozolomide stereotactic radiosurgery.
ABSTRACT Infections are increasingly recognized as a common complication of chimeric antigen receptor (CAR) T-cell therapy. The incidence clinically-defined infection after CD19.CAR therapy for relapsed/refractory lymphoma ranges from 60-90% in the first year CAR and is most cause non-relapse mortality. However, infectious risk targeting other malignancies not well understood. Herein, we report time, complications CD30.CAR treatment patients with Hodgkin’s peripheral lymphoma. Since CD30...
<h3>Background</h3> Myeloid cells are actively recruited to the solid tumor microenvironment (TME) and have potential mediate control via phagocytosis, TME remodeling, T cell activation. We previously developed human chimeric antigen receptor macrophages (CAR-Macrophage) shown potent anti-tumor activity in pre-clinical models.<sup>1</sup> The anti-HER2 CAR-Macrophage therapy product, CT-0508, was evaluated a Phase 1 trial as monotherapy combination with pembrolizumab. Clinical data...
The World Health Organization declared COVID-19 a pandemic on March 11, 2020, and it became national emergency 13, 2020 (Hauck et al., 2020). delivery of patient care was significantly affected, with precautions emphasized to protect vulnerable populations who are at the greatest risk for increased mortality from viral transmission infection, such as those immunocompromised cancer, diabetes, organ transplantation. As result, medical oncology community had act quickly patients exposure COVID-19.
Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it associated with significant related morbidity and mortality. There great need predictive biomarkers overall survival (OS) clinical outcomes. We hypothesized that circulating metabolic, inflammatory, immune molecules have potential as AML patients who receive HCT treatment. This retrospective study was designed an exploratory approach to comprehensively characterize...
80 Background: There is a critical need to address potential delays in care for patients (pts) with new, undiagnosed cancer academic medical centers that operate on subspecialty clinic model. To bridge this gap, we established an Undiagnosed Cancer Clinic (UCC) staffed by oncology physicians and advanced practice providers (APP) provide rapid access specialty-led diagnostic work-up, symptom management, disease education the transition subspecialists at final diagnosis. Methods: A referral...
Background: Women experiencing substance use disorders face barriers to treatment, including childcare, stigma and lack of gender/trauma-informed programming. Several non-government organizations in New South Wales run women-only treatment services address these needs. Objectives: We aim assess characteristics women entering services. Design: Data on client from six organization disorder between 2014 2018 were extracted a database containing demographics, drug psychological distress...
Abstract Lung cancer is the leading cause of cancer-related death in United States, and it estimated more than 220,000 new cases will be diagnosed 2011. The first-line therapy for advanced lung almost always contains a platinum-based chemotherapeutic agent, regardless disease's histological profile. In vitro studies have shown that isothiocyanate compounds can sensitize cells to cisplatin treatment, however underlying mechanisms not been well defined until now, there no vivo demonstrations...