A5012173490- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Brain Metastases and Treatment
- Ubiquitin and proteasome pathways
- Neutropenia and Cancer Infections
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- Childhood Cancer Survivors' Quality of Life
- Metastasis and carcinoma case studies
WinnMed
2014-2025
Mayo Clinic in Florida
2016-2025
Jacksonville College
2014-2024
Jacksonville University
2024
Nemours Children’s Clinic
2021-2024
Nemours Children's Clinic
2023-2024
St. George's University
2024
University of South Florida
2023
Mayo Clinic in Arizona
2022
Memorial Sloan Kettering Cancer Center
2022
Significant improvement in survival outcomes has been established with the addition of trastuzumab to adjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2) -positive early breast cancer treatment. However, may increase risk cardiac toxicity, and long-term evaluation its incidence factors are warranted.NCCTG (Alliance) N9831 trial compared doxorubicin cyclophosphamide (AC) followed by either weekly paclitaxel (arm A); then B); or plus alone C) patients HER2-positive...
Abstract Outcomes have improved considerably in multiple myeloma (MM), but disparities among racial‐ethnic groups exist. Differences utilization of novel therapeutics are likely contributing factors. We explored such differences from the SEER‐Medicare database. A analysis lenalidomide, thalidomide, bortezomib, and stem cell transplant (SCT) was performed for patients diagnosed with MM between 2007 2009, including use over time, by race, time‐dependent trends each racial subgroup, survival...
pansion states.These findings are consistent with age-adjusted state cancer mortality data reported by the US Centers for Disease Control and Prevention, which do not clearly demonstrate a difference that favors either expansion or nonexpansion states (Figure 1). 4 Baseline between being same after adjusting predictors of outcomes known to differ from suggests similar care is offered in different states.Clinically meaningful baseline differences survival before Affordable Care Act, combined...
Summary Deubiquitinase enzymes ( DUB s) of the proteasomal 19S regulatory particle are emerging as important therapeutic targets in several malignancies. Here we demonstrate that inhibition two proteasome‐associated s USP 14 and UCHL 5) with small molecule inhibitor b‐ AP 15, results apoptosis human Waldenström macroglobulinaemia WM ) cell lines primary patient‐derived tumour cells. Importantly, 15 produced proteotoxic stress cells have acquired resistance to proteasome bortezomib. In silico...
BACKGROUND Outcomes have improved significantly in multiple myeloma (MM), but racial disparities health care access and survival exist. A comprehensive analysis exploring MM is warranted. METHODS Patients with from 1991 to 2010 the Surveillance, Epidemiology, End Results‐Medicare database were evaluated for trends clinical myeloma‐defining events (MDEs), receipt of treatment (drugs stem cell transplantation; [SCT]), cost care, overall (OS). RESULTS Among 35,842 patients, frequency all MDEs...
Context: Previous studies suggestthe effect of metformin on TSH levels, but its impacton free T4 (fT4) levels has not been understood clearly. Objective:This Meta-analysis aims to studythe effects serum-free T4(fT4) in patients with or without underlying thyroid disease and/or diabetes. Data Sources:We reviewed articles from the Cochrane Library based systematic protocol. Extraction: Demographic, clinical, and relevant data was extracted. were analyzed according changes fT4 administration....
Activation of the RAS/MAPK pathway is associated with reduced tumor-infiltrating lymphocytes and poor outcomes in triple-negative breast cancer (TNBC). Previous studies demonstrated that inhibition MAPK a MEK inhibitor synergistic immune checkpoint inhibitors. We conducted phase I/II trial pembrolizumab binimetinib patients metastatic TNBC ≤ 3 prior lines therapy. There were two dose levels (DL) at 45 mg DL 0 30 -1. The recommended II was standard twice daily. objective response rate (ORR)...
"QIM25-237: Supporting Oncologists in Capturing and Using Structured Oncology Data Real-Time the Electronic Health Record (EHR)" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Abstract We conducted a surveillance epidemiology and end results ( SEER )‐based analysis to describe the incidence characteristics of second primary acute lymphoblastic leukemia sALL ) among adults (≥18 years) with history malignancies (1M). Standardized ratios SIR s) cases were calculated by site 1M stage. also evaluated differences in 5‐year survival age, site, extent 1M, latency after evidence underlying racial/ethnic disparity. identified 10,956 patients de‐novo/primary (1 ALL 772 ....
Background Invasive lobular carcinoma (ILC) comprises approximately ~10–20% of breast cancers. In general, multifocal/multicentric (MF/MC) cancer has been associated with an increased rate regional lymph node metastases. Tumor heterogeneity between foci represents a largely unstudied source genomic variation in those rare patients MF/MC ILC. Methods We characterized gene expression and copy number 2 or more from 11 ILC (all ER+, HER2-) adjacent normal tissue. RNA DNA were extracted 3x1.5mm...
National Cancer Institute (NCI)/National Comprehensive Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated.Adult MM diagnosed between 1973 and 2011 were identified from the Surveillance, Epidemiology, End Results database stratified by county of residence at time diagnosis year CC designation. The influence NCI/NCCN access, race, overall survival (OS) was evaluated with a...
Chronic lymphocytic leukemia (CLL) is the most common adult and currently incurable. To expand therapeutic armamentarium, we investigated neem leaf extract (NLE) after a patient with CLL demonstrated disease regression upon taking oral NLE. NLE-mediated apoptosis was examined in peripheral blood mononuclear cells (PBMCs) from 41 patients CLL. NLE induced dose-dependent reduction cell viability significant observed at 0.06% (w/v) by 24 h. Annexin-V staining poly(ADP-ribose) polymerase 1...
BACKGROUND: Paget’s disease of the breast is rare. The National Cancer Database (NCDB) one largest tumor databases in United States. METHODS: We queried NCDB to identify male and female patients with who were treated from January 1, 2004, through December 31, 2015. No age limitations applied. Descriptive statistical analysis survival performed. RESULTS: analyzed demographic, disease, treatment characteristics 7,191 breast. median (range) was 64 (20–90) years. Only 2.1% men, 85.4% white. most...
Abstract Background mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic is unknown. We here present a temporal vaccination in oncology patients undergoing standard care PET. Methods 262 were included analysis. 231 had at least one dose vaccine while 31 not been vaccinated. The SUVmax lymph nodes ipsilateral was compared contralateral obtain absolute change (ΔSUVmax). Results ΔSUVmax more significant shorter times...
Background: Thirty-six states, including Florida, have legalized marijuana for medical and/or recreational use, yet how it is used and perceived by persons with cancer not well understood. Objectives: The purpose of this study was to identify patterns benefits, side effects (MMJ) among patients in Florida. Methods: For descriptive, cross-sectional study, anyone residing within the state Florida who diagnosed or treated a malignancy last five years had MMJ eligible. An online survey...
Doxorubicin (DOX) and trastuzumab (TRA) are associated with cardiac dysfunction.High-sensitivity troponin T (hs-TnT) brain natriuretic peptide attached to the amino acid N-terminal fragment in prohormone (NT-proBNP) were measured before on days +1, +2, +3, +7 during cycles 1 2 of therapy DOX or TRA breast cancer patients.Five eleven DOX-treated women, compared 2/11 TRA-treated had undetectable baseline hs-TnT. By day +1 cycle 2, all women (p = 0.03) but only 7/11 ns) detectible Time peak was...