A5029846347- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Virus-based gene therapy research
- Palliative Care and End-of-Life Issues
- Ethics in Clinical Research
- Animal Genetics and Reproduction
- Biomedical and Engineering Education
- Cancer survivorship and care
- Cutaneous Melanoma Detection and Management
- Cancer Risks and Factors
- Patient-Provider Communication in Healthcare
- Viral Infectious Diseases and Gene Expression in Insects
- Childhood Cancer Survivors' Quality of Life
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Health Systems, Economic Evaluations, Quality of Life
- Cultural Competency in Health Care
- Economic and Financial Impacts of Cancer
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Public Health Policies and Education
- Ethics in medical practice
- Food Security and Health in Diverse Populations
- AI in cancer detection
Mayo Clinic
2008-2023
Jacksonville College
2018-2023
Mayo Clinic in Florida
2007-2023
WinnMed
2012-2023
Park Terrace Care Center
2020
Mayo Clinic in Arizona
2002-2017
American Society of Clinical Oncology
2017
University of Wisconsin–Madison
2017
Fraternal Order of Eagles
2005-2017
Nemours Children’s Clinic
2017
Treatment with an aromatase inhibitor for 5 years as up-front monotherapy or after tamoxifen therapy is the treatment of choice hormone-receptor-positive early breast cancer in postmenopausal women. Extending to 10 may further reduce risk breast-cancer recurrence.
The American Cancer Society, the Centers for Disease Control and Prevention, National Institute, North Association of Central Registries collaborate annually to provide updated information on cancer occurrence trends in U.S. 2007 report features a comprehensive compilation Indians Alaska Natives (AI/AN).Cancer incidence data were available up 82% population. deaths entire Long-term (1975 through 2004) fixed-interval (1995 mortality evaluated by annual percent change using regression analyses...
Edmonston vaccine strains of measles virus (MV) have shown significant antitumor activity in preclinical models ovarian cancer. We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) also permit real-time monitoring viral gene expression tumors clinical setting. Patients with Taxol and platinum-refractory recurrent cancer normal CEA levels were eligible for this phase I trial. Twenty-one patients treated MV-CEA i.p. every 4 weeks up 6 cycles at seven different...
Alcohol drinking is an established risk factor for several malignancies, and it a potentially modifiable cancer. The Cancer Prevention Committee of the American Society Clinical Oncology (ASCO) believes that proactive stance by to minimize excessive exposure alcohol has important implications cancer prevention. In addition, role on outcomes in patients with its formative stages, ASCO can play key generating research agenda. Also, could provide needed leadership community this issue. issuance...
Objectives. We used improved data on American Indian and Alaska Native (AI/AN) ancestry to provide an updated comprehensive description of cancer mortality incidence among AI/AN populations from 1990 2009. Methods. linked the National Death Index central registry records independently Health Service (IHS) patient registration database improve identification persons in data, respectively. Analyses were restricted non-Hispanic residing Contract Delivery Area counties 6 geographic regions...
Abstract BACKGROUND Small cell carcinoma (SCC) of the urinary bladder accounts for 0.35–0.70% all tumors. There is no standard approach to management SCC bladder. METHODS The authors performed a retrospective study at Mayo Clinic (Rochester, MN) characterize clinical and pathologic features patients with diagnosed between 1975 2003 emphasis on management. RESULTS Forty‐four were identified who had primary SCC, 61.4% whom pure SCC. male:female ratio was 3:1, mean age 66.9 years, follow‐up 3.2...
Abstract BACKGROUND Prostate cancer is the most commonly diagnosed malignancy in American men, yet treatment of its metastatic androgen‐independent form remains inadequate. This mandates development new therapies such as immunotherapy. In this Phase 2 trial, we determined efficacy antigen presenting cells (APCs) loaded with PA2024, a recombinant fusion protein containing prostatic acid phosphatase (PAP) and GM‐CSF. METHODS We enrolled 21 patients histologically documented prostate carcinoma...
Abstract Background: Cancer incidence rates for American Indian and Alaska Native (AI/AN) populations vary by geographic region in the United States. The purpose of this study is to examine cancer trends AI/AN population compared with non-Hispanic white States years 2010 2015. Methods: Cases diagnosed during 2015 were identified from population-based registries linked Health Service (IHS) patient registration databases describe persons whites (whites) living IHS purchased/referred care...
Abstract BACKGROUND Patients with metastatic melanoma (MM) have very few therapy options. Based on reports of responses to paclitaxel and carboplatin (PC), 31 patients MM were treated PC. METHODS Data regarding PC abstracted from medical records. Clinical outcomes as determined by the treating oncologist used for this analysis. Response determination was retrospectively confirmed using Evaluation Criteria in Solid Tumors (RECIST). RESULTS Thirty‐one had a median 2 previous therapies,...
Thrombospondins are natural inhibitors of angiogenesis, tumor metastases, and growth (melanoma). ABT-510 is a synthetic analog thrombospondin-1, well tolerated in phase I studies. We conducted II trial evaluating the clinical efficacy its effects on biomarkers angiogenesis immunity patients with metastatic melanoma (MM).A 2-stage was to assess efficacy, safety, pharmacodynamic (angiogenesis immunity) stage IV melanoma. The primary endpoint 18-week treatment failure rate. Patients...
Abstract BACKGROUND: Increasing evidence shows chemotherapy in combination with vascular endothelial growth factor (VEGF) inhibition is a clinically active therapy for patients metastatic melanoma (MM). METHODS: A phase 2 trial was conducted chemotherapy‐naive unresectable stage IV MM who were randomized to temozolomide (200 mg/m on days 1 through 5) and bevacizumab (10 mg/kg intravenously 15) every 28 (Regimen TB) or nab ‐paclitaxel (100 , 80 post‐addendum 5 secondary toxicity, 1, 8, 15),...
To determine if there is a factor in the serum of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) that causes proliferation.Human melanocytes and melanoma cells were grown exposed to or plasma BDUMP, other neoplastic conditions, control media. Preliminary studies using conducted an unmasked fashion. In addition, IgG-depleted IgG-enriched was also tested similar Experiments triple masked. show melanocyte selective, human dermal fibroblasts, keratinocytes, ovarian...
BACKGROUND. Cancer incidence rates vary among American Indian and Alaska Native (AI/AN) populations often differ from non-Hispanic whites (NHWs). However, the misclassification of race for AI/AN cancer cases in central registries may have led to underestimates burden previous reports. METHODS. Cases diagnosed during 1999 through 2004 were identified population-based United States. Age-adjusted calculated 25 most common sites AI/ANs NHWs. To minimize race, registry records linked with patient...
BACKGROUND. Breast cancer is a leading cause of morbidity and mortality among American Indian Alaska Native (AI/AN) women. Although published studies have suggested that breast rates AI/AN women are lower than those other racial ethnic populations, accurate determinations the burden been hampered by misclassification race. METHODS. Cancer incidence data from National Program Registries Surveillance, Epidemiology, End Results were combined to estimate age-adjusted for diagnosis years 1999...
Objectives. We compared breast cancer death rates and mortality trends among American Indian/Alaska Native (AI/AN) White women using data for which racial misclassification was minimized. Methods. used deaths cases linked to Indian Health Service (IHS) calculate age-adjusted 95% confidence intervals (CIs) by IHS-designated regions from 1990 2009 AI/AN women; Hispanics were excluded. Mortality-to-incidence ratios (MIR) calculated 1999 as a proxy prognosis after diagnosis. Results. Overall,...
Mammalian target of rapamycin (mTOR) pathway is activated in malignant melanoma and situ lesions as opposed to benign nevi. Inhibition PI3K-Akt-mTOR signaling implicated sensitization cells alkylating agents (temozolomide [TMZ]) inhibition tumor angiogenesis.We conducted a single-arm phase II multi-institution cooperative group study assess the antitumor activity safety profile combination TMZ derivative everolimus patients with metastatic unresectable melanoma. Patients received 10 mg/d...
We examined the role of paclitaxel and cisplatin as first line therapy for metastatic urothelial cancer.A total 34 patients were enrolled in this study, all eligible treatment assessable response. Patients received 135 mg./m.2 intravenously 3 hours followed by 70 2 every weeks to a maximum 6 cycles.Of 70% experienced major response treatment, which was partial/regression 38% complete 32%. Toxicity manageable with no episodes grade 4 leukopenia or thrombocytopenia. Nonhematological toxicities...
Objectives: Therapeutic peptide vaccines for melanoma continue to only demonstrate anecdotal success. We set out evaluate the impact of low-dose GM-CSF emulsified in Montanide ISA-51 on immunogenicity HLA-A2 restricted differentiation antigen (MART-1, gp100 and tyrosinase) administered separate subcutaneous injections. Methods: conducted a randomized phase II clinical trial HLA-A2+ patients with metastatic that were immunized every 3 weeks one following vaccine preparations: (A) peptides +...
Background: We describe reach, partnerships, products, benefits, and lessons learned of the 25 Community Network Programs (CNPs) that applied community-based participatory research (CBPR) to reduce cancer health disparities. Methods: Quantitative qualitative data were abstracted from CNP final reports. Qualitative grouped by theme. Results: Together, CNPs worked with more than 2,000 academic, clinical, community, government, faith-based, other partners. They completed 211 needs assessments,...