A5046889994- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Frailty in Older Adults
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- T-cell and B-cell Immunology
- Mobile Health and mHealth Applications
- Health Systems, Economic Evaluations, Quality of Life
- Peptidase Inhibition and Analysis
- Economic and Financial Impacts of Cancer
- Protein Degradation and Inhibitors
- Biosimilars and Bioanalytical Methods
- Mycobacterium research and diagnosis
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
Duke University
2020-2024
Duke Medical Center
2019-2024
Duke Cancer Institute
2020-2024
Duke University Hospital
2019-2023
Stanford Medicine
2017
St. Luke's Hospital
2010
Howard Hughes Medical Institute
2008
Epidemiological studies have associated certain human disease outcomes with particular killer cell Ig-like receptor (KIR) and HLA genotypes. However, the functional explanation for these associations is poorly understood, because KIRs were initially described as natural (NK) inhibitory receptors specificity molecules on their cellular targets. Yet resolution of infections often genotypic pairing cognate ligands. Recent in mice indicate a second role MHC-specific receptors, i.e., self-MHC...
Hematopoietic stem cell transplantation (HCT) is a curative treatment option for patients with hematologic conditions but presents many complications that must be managed as complex, chronic condition. Mobile health applications (mHealth apps) may permit tracking of symptoms in HCT. In seeking strategies to manage the complexities HCT, our team collaborated Sicklesoft, Inc., develop an mHealth app specifically HCT allow daily evaluation patient health, Technology Recordings better Understand...
(1) Background: There is evidence that abnormality in lipid metabolism promotes cancer development. This study investigated whether level and its variability are associated with the development of MM at a population level. (2) Methods: A retrospective cohort included total 3,527,776 subjects aged 40 above who participated ≥3 health examinations within previous five years, including index year (2012–2013). Total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C)...
Despite the exciting advancement of novel therapies, chronic graft-versus-host disease (cGVHD) remains most common cause non-relapse mortality after allogeneic hematopoietic stem cell transplantation (HCT). Frontline treatment cGVHD involves systemic steroids, which are associated with significant morbidities. We previously found that inhibition spleen tyrosine kinase (SYK) fostamatinib preferentially eradicated aberrantly activated B cells in both ex vivo studies patient cells, as well...
Anaplastic multiple myeloma (AMM) is a very rare but distinct subtype of (MM) with an extremely poor prognosis. Due to its rarity, AMM lacks detailed descriptions and clear definitions. Moreover, there no consensus on the treatment evidence suggests that responds poorly several novel therapies. We conducted literature review retrospective case series determine clinical characteristics, pathological features, outcomes AMM.Published reports since 1983 were systematically extracted reviewed. A...
Allogeneic hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for both malignant and nonmalignant hematologic diseases; however, reported rates of treatment-related mortality approach 30%. Outcomes are worse in patients who begin HCT with functional impairments. To detect such impairments, geriatric assessment (GA) recommended adults age ≥65 years. Younger candidates also may be impaired because chemotherapy regimens pre-HCT. Therefore, we hypothesized that GA...
Patients undergoing allogeneic (allo) and autologous (auto) hematopoietic cell transplantation (HCT) require extensive hospitalizations or daily clinic visits for the duration of their transplantation. Home HCT, wherein patients live at home providers make trips to patient's residence perform assessments deliver any necessary interventions, may enhance patient quality life improve outcomes. We conducted first study HCT in United States evaluate this model US healthcare setting determine...
PURPOSE We investigated the prevalence of financial toxicity in a population undergoing hematopoietic cell transplantation (HCT) evaluation and measured its impact on post-transplant clinical health-related quality-of-life outcomes. MATERIALS AND METHODS This was prospective study patients for allogeneic HCT between January 1, 2018, September 23, 2020, at large academic medical center. Financial health via baseline survey comprehensive score toxicity-functional assessment chronic illness...
Despite the growing interest in Alzheimer's disease, issues of ethnicity and culture associated with dementia are still under-studied. In this study, particular attention was given to Korean caregivers who seem suffer most terms family burdens emotional distress. Content analysis performed on 798 messages posted online support groups for caregivers. The results indicated that expressed more burden (“impact finance” “sense entrapment”) than U.S. Also, negative emotions caregivers,...
Bloodstream infections (BSIs) occur in 20% to 45% of inpatient autologous and allogeneic hematopoietic cell transplant (HCT) patients. Daily bathing with the antiseptic chlorhexidine gluconate (CHG) has been shown reduce incidence BSIs critically ill patients, although very few studies include HCT patients or have evaluated impact compliance on effectiveness. We conducted a prospective cohort study historical controls assess CHG rate gut microbiota composition among adults undergoing at Duke...
Life expectancy for long-term survivors of allogeneic hematopoietic stem cell transplantation (alloHSCT), defined as those living ≥5 years post-transplantation, is significantly lower compared with that the age-matched general population despite a relatively low primary disease relapse rate at >2 post-transplantation. Among several factors, patient sex increasingly recognized prognostic indicator survival. We examined influence and donor-recipient matching on overall survival (OS) in...
Recent studies have revealed the possible association between serum cholesterol levels and hematologic malignancy (HM). However, limited information is available about how reproductive factors interact with this association. Therefore, we investigated roles of in risk HM according to menopausal status. We finally identified 1,189,806 premenopausal 1,621,604 postmenopausal women who underwent a national health screening program 2009 using data from Korean National Health Insurance Service...
Allogeneic hematopoietic stem cell transplantation (HCT) has the potential to cure hematologic malignancies but is associated with significant morbidity and mortality. Although deaths during first year after are often attributable treatment toxicities complications, death may be due sequelae of accelerated aging caused by cellular senescence. Cytotoxic therapies radiation used in cancer treatments conditioning regimens for HCT can induce at molecular level; patients experience time-dependent...
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized hepatic steatosis on pre-HCT computed tomography (CT) scans a marker development of GVHD and poor outcomes allo-HCT. In this retrospective study, we reviewed the CT transplant outcome data patients who underwent allo-HCT at Duke University Medical Center from...
Background Allogeneic hematopoietic stem cell transplantation (HCT) is an often curative intent treatment, however it associated with significant gastrointestinal (GI) toxicity and treatment related mortality. Graft-versus-host disease a contributor to transplant-related We performed phase 2 trial of the somatostatin analog pasireotide prevent GVHD after myeloablative allogeneic HCT. Methods Patients received 0.9mg every 12 hours from day prior conditioning through +4 HCT (or maximum 14...
e18517 Background: Myeloproliferative neoplasms (MPN) and myelodysplastic syndrome (MDS)/MPN overlap syndromes are rare hematopoietic malignancies in which allogeneic cell transplantation (HCT) is the only treatment with curative potential. Even for higher risk patients, optimal timing HCT largely unknown. We interrogated outcomes of myelofibrosis (MF) rest MPN, MDS/MPN based on from diagnosis (Dx) to help oncologists determine refer patients HCT. Methods: This retrospective, single-center...