A5010749612- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Polyomavirus and related diseases
- Neonatal Respiratory Health Research
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Lysosomal Storage Disorders Research
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Renal Transplantation Outcomes and Treatments
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood groups and transfusion
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
Medical College of Wisconsin
2021-2024
National Marrow Donor Program
2022-2023
Duke University Hospital
2009-2022
Duke Medical Center
2013-2022
Duke University
2011-2022
Palmetto Hematology Oncology
2021
Children's Hospital of Wisconsin
2021
Imperial College London
2021
University of Central Florida
2021
Marcus (United States)
2018-2020
Importance Preventing relapse for adults with acute myeloid leukemia (AML) in first remission is the most common indication allogeneic hematopoietic cell transplant. The presence of AML measurable residual disease (MRD) has been associated higher rates, but testing not standardized. Objective To determine whether DNA sequencing to identify variants blood before transplant identifies patients at increased risk and poorer overall survival compared those without these variants. Design, Setting,...
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of hematopoietic cell transplantation (HCT) associated with significant morbidity and mortality. However, TA-TMA a clinical diagnosis, multiple criteria have been proposed without universal application. Although some patients self-resolving disease, others progress to multiorgan failure and/or death. Poor prognostic features also are not uniformly accepted. The lack harmonization...
The use of HLA-mismatched donors could enable more patients with ethnically diverse backgrounds to receive allogeneic hematopoietic cell transplantation (HCT) in the United States. However, real-world trends and outcomes following mismatched donor HCT for remain largely undefined. We conducted this study determine whether platforms have increased access patients, particularly through application novel graft-versus-host disease (GVHD) prophylaxis regimens, are comparable those non-Hispanic...
Persistence of FLT3 internal tandem duplication (ITD) in adults with acute myeloid leukemia (AML) first complete remission (CR) prior to allogeneic hematopoietic cell transplant (HCT) is associated increased relapse and death after transplant, but the association between level measurable residual disease (MRD) detected clinical outcome unknown.
Graft failure occurs in approximately 20% of patients after unrelated umbilical cord blood transplantation (UCBT). This could be because inadequate potency the unit (CBU). To this end, we investigated impact graft characteristics on engraftment and survival 435 primarily pediatric (median age: 5.3 years) receiving a single-unit UCBT myeloablative conditioning from 2000 to 2008. Pre-cryopreservation (pre-cryo) were provided by banks. Post-thaw parameters measured dextran/albumin-washed...
Hematopoietic cell transplantation (HCT) has been successfully used to treat many malignant and nonmalignant conditions. As supportive care, donor selection, treatment modalities evolve, documenting HCT trends outcomes is critical. This report from the Center for International Blood Marrow Transplant Research (CIBMTR) provides an update on current activity survival rates in United States. Additional data use of adolescent young adult (AYA) population are included. AYA patients more...
Background Banked unrelated donor umbilical cord blood ( CB ) has improved access to hematopoietic stem cell transplantation for patients without a suitably matched donor. In resource‐limited environment, ensuring that the public inventory is enriched with high‐quality units CBUs addressing needs of diverse group priority. Identification characteristics correlating higher CBU quality could guide operational strategies increase yield banked . Study Design and Methods Characteristics 5267...
Allogeneic hematopoietic stem cell transplantation (HSCT) can retard the progression of early infantile Krabbe disease (EIKD). Superior outcomes are achieved if HSCT is performed before onset symptoms; however, little information available about long-term in surviving patients. We now describe functional presymptomatic infants who underwent for EIKD at ≤ 2 months age. Records 19 patients age from 1996 to 2010 were reviewed. Long-term compared between those transplanted < 30 days and ≥ life....
Pediatric aggressive mature B-cell lymphomas are the most common types of non-Hodgkin lymphoma in children, and they include Burkitt (BL) diffuse large (DLBCL). These diseases highly but curable, treatment is complex, patients may have many complicated supportive care issues. The NCCN Guidelines for Aggressive Mature B-Cell Lymphomas provide guidance regarding pathology diagnosis, staging, initial treatment, disease reassessment, surveillance, therapy relapsed/refractory disease, clinicians...
Abstract When hematopoietic stem cell transplant (HSCT) is necessary for children with acute myeloid leukemia (AML), there remains debate about the best source. Post-HSCT relapse a common cause of mortality, and complications such as chronic graft versus host disease (cGVHD) are debilitating life-threatening. To compare post-HSCT outcomes different donor sources, we retrospectively analyzed consecutive transplants performed in several international centers from 2005 to 2015. A total 317...
Haploidentical hematopoietic cell transplantation (HCT) with posttransplant cyclophosphamide (PTCy) graft-versus-host-disease (GVHD) prophylaxis yields a similar overall survival (OS) to HLA-matched unrelated donor (MUD) HCT conventional prophylaxis. Given the prognostic implications of age, we investigated impact age (younger [<35 years, n = 868] vs older [≥35 418]) and type (haploidentical [n 373] MUD 913]) on OS in adult patients acute lymphoblastic leukemia (ALL). Older was independently...
Autoimmune cytopenias are a recognized complication of hematopoietic stem cell transplant (HSCT), and considered to be feature chronic graft-versus-host disease (cGVHD). We report on cohort very young infants (≤3 months age) receiving HSCT from unrelated donor umbilical cord blood for genetic disorders who developed posttransplant autoimmune at an increased rate compared older aged controls. These received conditioning regimen consisting busulfan, cyclophosphamide, antithymocyte globulin...
We describe haploidentical bone marrow transplantation with post-transplant cyclophosphamide (PT-CY) for 30 patients Fanconi anemia (FA). Twenty-six were transplanted upfront, and the preparatory regimens included fludarabine 150 mg/m2 + total body irradiation 200 to 300 cGy ± CY 10 mg/kg without (n = 12) or rabbit antithymocyte globulin (r-ATG) 4 5 14). Four rescued after primary secondary graft failure related unrelated donor above regimen 2) r-ATG 2). PT-CY at 25 mg/kg/day (total dose, 50...
This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 autologous (auto) HSCT United States between 2008 2014. In both settings, there was a greater proportion boys (n = 4327; 57%), children < 10 years age 4412; 59%), whites 5787; 77%), performance score ≥ 90% at 6187; 83%). Leukemia most common indication an allo-transplant 4170;...
Key Points A 6-year overall survival of 61% was observed in leukodystrophy patients after cord blood transplantation. Mismatched donors, symptomatic disease, and lower PS before transplantation were predictors survival.
Highlights•Late fatal infection (LFI) contributed to one-third of the deaths in both adult and pediatric hematopoietic cell transplantation (HCT) recipients surviving 2 years post-HCT.•In adults age ≥20 years, receipt matched unrelated donor (MUD) or mismatched (MMUD) HCT male sex were associated with an increased risk LFI.•In subjects, ≥10 MUD MMUD HCT, inherited abnormalities erythrocyte function LFI.ABSTRACTWe analyzed late infections (LFIs) allogeneic stem reported Center for...
We examined the impact of vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) on outcomes allogeneic hematopoietic cell transplantation (HCT) utilizing Center for International Blood and Marrow Transplant Research database.Adult pediatric patients (N = 7128) who underwent first HCT acute leukemia or myelodysplastic syndrome from 2008 through 2012 were analyzed as 3 groups-VRE BSI, non-VRE without BSI-according to BSI status at 100 days (D100) after HCT. Multivariable models...
Abstract There is marked paucity of data regarding late effects in adolescents and young adults (AYAs) who undergo myeloablative conditioning (MAC) allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML). We evaluated survival 826 1-year disease-free survivors MAC HCT AYA AML, with an additional focus on comparing based upon type (total body irradiation [TBI] vs high-dose chemotherapy only). The estimated 10-year cumulative incidence subsequent neoplasms was 4%...
Our understanding of health has changed substantially since the World Health Organization initially defined in 1948 as "a state complete physical, mental and social well-being not merely absence disease or infirmity". These changes include reconceptualizing on a continuum rather than static state, adding existential to mental, well-being. Further, good requires adaptation coping with stress is influenced by social, personal environmental factors. Building prior work, we propose reconsidered...