A5101695997- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Statistical Methods and Inference
- Acute Myeloid Leukemia Research
- Statistical Methods in Clinical Trials
- Chronic Myeloid Leukemia Treatments
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Histone Deacetylase Inhibitors Research
- Polyomavirus and related diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Plant Pathogens and Fungal Diseases
- Antifungal resistance and susceptibility
- Sperm and Testicular Function
- Insurance, Mortality, Demography, Risk Management
- Immunotherapy and Immune Responses
- Neutropenia and Cancer Infections
Medical College of Wisconsin
2016-2025
Hospital of Hebei Province
2024
Tongde Hospital of Zhejiang Province
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2020-2023
Second Affiliated Hospital of Zhejiang University
2023
Mayo Clinic in Arizona
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Shandong University
2019-2022
Shandong Provincial Hospital
2019-2022
Institute of Dermatology
2022
The use of HLA-mismatched donors could enable more patients with ethnically diverse backgrounds to receive allogeneic hematopoietic cell transplantation (HCT) in the United States. However, real-world trends and outcomes following mismatched donor HCT for remain largely undefined. We conducted this study determine whether platforms have increased access patients, particularly through application novel graft-versus-host disease (GVHD) prophylaxis regimens, are comparable those non-Hispanic...
PURPOSE: To evaluate the results of high-dose chemotherapy and autologous hematopoietic stem-cell transplantation (autotransplants) in patients with diffuse aggressive non-Hodgkin’s lymphoma (NHL) who never achieve a complete remission conventional chemotherapy. PATIENTS AND METHODS: Detailed records from Autologous Blood Marrow Transplant Registry (ABMTR) on 184 NHL achieved subsequently received an autotransplant were evaluated. Transplants performed between 1989 1995 reported to ABMTR by...
The problem of testing for a centre effect in multi-centre studies following proportional hazards regression analysis is considered. Two approaches to the can be used. One fits model with fixed covariate included each (except one). need specific adjustment evaluated using either score, Wald or likelihood ratio test hypothesis that all effects are equal zero. An alternative approach introduce random frailty into model. Recently, Commenges and Andersen have proposed score this By Monte Carlo...
Abstract BACKGROUND: The purpose of the current study was to determine whether use hematopoietic stem cell transplantation (HCT) treat leukemia, lymphoma, or multiple myeloma (MM) differs by race and sex. METHODS: annual incidence MM estimated in United States people aged <70 years sex using Surveillance, Epidemiology, End Results (SEER) cancer registry between 1997 2002 US census reports for year 2000. autologous, human leukocyte antigen (HLA) identical sibling, unrelated HCT performed...
In this paper we describe flexible competing risks regression models using the comp.risk() function available in <strong>timereg</strong> package for R based on Scheike et al. (2008). Regression are specified transition probabilities, that is cumulative incidence setting. The model contains Fine and Gray (1999) as a special case. This can be used to do goodness-of-fit test subdistribution hazards’ proportionality assumption (Scheike Zhang 2008). program also construct confidence bands...
Abstract The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes HCT approaches by donor adults with ALL in remission. primary objective was to compare overall survival (OS) among HCTs PTCy and HLA-matched sibling (MSD), 8/8 unrelated (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing MSD HCT,...
Abstract With competing risks failure time data, one often needs to assess the covariate effects on cumulative incidence probabilities. Fine and Gray proposed a proportional hazards regression model directly subdistribution of risk. They developed estimating procedure for right‐censored based inverse probability censoring weighting. Right‐censored left‐truncated data sometimes occur in biomedical researches. In this paper, we study risk with data. We adopt new weighting technique estimate...
Autologous hematopoietic cell transplantation (AHCT) for plasma myeloma is performed less often in people >70 years old than ≤70 old. We analyzed 11,430 AHCT recipients prospectively reported to the Center International Blood and Marrow Transplant Research between 2008 2011, representing majority of US activity during this period. Survival (OS) was compared 3 cohorts: ages 18 59 (n = 5818), 60 69 4666), 946). Median OS not reached any cohort. In multivariate analysis, increasing age...
BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo‐HCT) remains the only potentially curative treatment option for relapsed follicular lymphoma (FL), yet questions remain about optimal timing. This study analyzed long‐term outcomes and associated factors among recipients of allo‐HCT with FL. METHODS Patients FL who underwent from 2001 to 2011 a human leukocyte antigen (HLA)–matched donor were included. Outcome analyses overall survival (OS), progression‐free (PFS),...
Although allogeneic hematopoietic cell transplantation (alloHCT) offers cure for older patients with acute lymphoblastic leukemia (ALL), disease relapse remains a major issue. Whether matched sibling donors (MSDs) are still the preferred donor choice compared to younger unrelated (MUDs) in contemporary era of improved practices unknown. This retrospective cohort registry study queried Center International Blood and Marrow Transplant Research (CIBMTR) database B ALL (B-ALL) age ≥ 50 years...
Objective: To determine whether the conclusions of a 1991 study, which showed that adults with acute lymphoblastic leukemia in first remission had similar leukemia-free survival rates when treated chemotherapy or HLA-identical sibling bone marrow transplantation, remain valid after more than 4 years additional follow-up. Design: Retrospective comparison two cohorts patients using left-truncated Cox regression to adjust for differences baseline characteristics and time treatment. Setting...
Summary In some clinical studies comparing treatments in terms of their survival curves, researchers may anticipate that the curves will cross at point, leading to interest a long‐term comparison. However, simple comparison fixed point be inefficient, and use weighted log‐rank test overly sensitive early differences survival. We formulate problem as one testing for after prespecified time propose variety techniques this hypothesis. study these methods using simulation illustrate them on...
With competing risks data, one often needs to assess the treatment and covariate effects on cumulative incidence function. Fine Gray proposed a proportional hazards regression model for subdistribution of risk with assumption that censoring distribution covariates are independent. Covariate-dependent sometimes occurs in medical studies. In this paper, we study proper adjustments covariate-dependent censoring. We consider covariate-adjusted weight function by fitting Cox using predictive...
Emerging epidemiological studies indicate that hypercholesterolaemia is a risk factor for testosterone deficiency. However, the underlying mechanism unclear. Testicular Leydig cells are primary source of in males. To identify effect and cholesterol overload on cell function, rats were fed with HC (HC) diet to induce hypercholesterolaemia. During 16-week feeding period, serum levels reduced time-dependent manner diet. Accordingly, these steroidogenic enzymes within cells, including acute...
Summary. We studied the association between CD34 cell dose and transplant outcomes in 359 bone marrow (BM) 511 peripheral blood stem (PBSC) recipients from human leucocyte antigen (HLA)‐identical siblings, reported to International Bone Marrow Transplant Registry (IBMTR). Transplants for leukaemia were performed 1995 1998. Patients divided into those receiving below or above median + dose, BM (3 × 10 6 /kg) PBSC (6 grafts respectively. Cox proportional hazards regression was used adjust...
A frequent occurrence in medical research is that a patient subject to different causes of failure, where each cause known as competing risk. The cumulative incidence curve proper summary curve, showing the failure rates over time due particular cause. common question assess covariate effects on function. standard approach construct regression models for all cause-specific hazard rate functions and then model covariate-adjusted function hazards given set covariates. New methods have been...
This study described long-term outcomes of autologous haematopoietic-cell transplantation (HCT) for advanced Hodgkin (HL) and non-Hodgkin lymphoma (NHL). The included recipients HCT HL (N = 407) NHL 960) from 1990-98 who were in continuous complete remission at least 2 years post-HCT. Median follow-up was 104 months 107 NHL. Overall survival 10-years 77% (72-82%) HL, 78% (73-82%) diffuse large-cell NHL, (71-83%) follicular 85% (75-93%) lymphoblastic/Burkitt 52% (37-67%) mantle-cell (67-85%)...