A5050581544- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- vaccines and immunoinformatics approaches
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Chronic Lymphocytic Leukemia Research
- Soybean genetics and cultivation
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Hemoglobinopathies and Related Disorders
- Legume Nitrogen Fixing Symbiosis
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Polyomavirus and related diseases
- Biomedical Ethics and Regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
National Marrow Donor Program
2016-2025
Midwest Orthopaedic Research Foundation
2023
University of Minnesota Rochester
2019
University of Minnesota
2012-2018
United States Department of Agriculture
2010-2012
Agricultural Research Service
2009-2012
University of Illinois Urbana-Champaign
2011
National Center for Genome Resources
2011
Iowa State University
2011
The use of HLA-mismatched donors could enable more patients with ethnically diverse backgrounds to receive allogeneic hematopoietic cell transplantation (HCT) in the United States. However, real-world trends and outcomes following mismatched donor HCT for remain largely undefined. We conducted this study determine whether platforms have increased access patients, particularly through application novel graft-versus-host disease (GVHD) prophylaxis regimens, are comparable those non-Hispanic...
Hematopoietic cell transplantation (HCT) has been successfully used to treat many malignant and nonmalignant conditions. As supportive care, donor selection, treatment modalities evolve, documenting HCT trends outcomes is critical. This report from the Center for International Blood Marrow Transplant Research (CIBMTR) provides an update on current activity survival rates in United States. Additional data use of adolescent young adult (AYA) population are included. AYA patients more...
Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in -C disparities single class I HLA-mismatched UD-HCT.
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic transplantation (alloHCT). The donor’s Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK activation by activating KIR-ligand interactions or minimizing inhibitory interactions. Alternative classifications intended predicting alloHCT donor...
The nutritional and economic value of many crops is effectively a function seed protein oil content. Insight into the genetic molecular control mechanisms involved in deposition these constituents developing needed to guide crop improvement. A quantitative trait locus (QTL) on Linkage Group I (LG I) soybean (Glycine max (L.) Merrill) has striking effect content.A near-isogenic line (NIL) pair contrasting differing an introgressed genomic segment containing LG QTL was used as resource...
Race, ethnicity, and ancestry are terms that often misinterpreted and/or used interchangeably. There is lack of consensus in the scientific literature on definition these insufficient guidelines proper classification, collection, application this data community. However, defining groups for human populations crucial multiple healthcare applications clinical research. Some examples impacted by population classification include HLA matching stem-cell or solid organ transplant, identifying...
In patients without a matched sibling donor (MSD) or well-matched unrelated (MUD), hematopoietic cell transplantation (HCT) can still be successful when using an HLA-mismatched (MMUD) in combination with post-transplantation cyclophosphamide (PTCy), abatacept, other novel approaches. This may allow clinicians to choose suitable from wide range of options while optimizing selection characteristics, including age. We hypothesized that allowing for 5/8 HLA match level considering...
Unambiguous HLA typing is important in hematopoietic stem cell transplantation (HSCT), disease association studies, and solid organ transplantation. However, current molecular methods only interrogate the antigen recognition site (ARS) of genes, resulting many cis-trans ambiguities that require additional to resolve. Here we report high-resolution 10,063 National Marrow Donor Program (NMDP) registry donors using long-range PCR by next generation sequencing (NGS) approach on buccal swab...
Acquired aplastic anemia (AA) is caused by autoreactive T cell-mediated destruction of early hematopoietic cells. Somatic loss human leukocyte antigen (HLA) class I alleles was identified as a mechanism immune escape in surviving cells some patients with AA. However, pathogenicity, structural characteristics, and clinical impact specific HLA AA remain poorly understood. Here, we evaluated somatic 505 from 2 multi-institutional cohorts. Using combination mutation frequencies, peptide-binding...
We present an electronic format for exchanging data HLA and KIR genotyping with extensions next-generation sequencing (NGS). This addresses NGS exchange by refining the Histoimmunogenetics Markup Language (HML) to conform proposed Minimum Information Reporting Immunogenomic Genotyping (MIRING) reporting guidelines (miring.immunogenomics.org). Our refinements of HML include two major additions. First, is supported new XML structures capture additional metadata required produce a result,...