A5003800717- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Nonmelanoma Skin Cancer Studies
- Multiple Myeloma Research and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- Liver physiology and pathology
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Melanoma and MAPK Pathways
- Cancer and Skin Lesions
- Advanced Biosensing Techniques and Applications
- Myasthenia Gravis and Thymoma
- Pregnancy and Medication Impact
- Prostate Cancer Treatment and Research
University of Miami
2011-2025
Sylvester Comprehensive Cancer Center
2010-2025
University of Miami Health System
2024
University of Miami Hospital
2018
The University of Texas MD Anderson Cancer Center
2006-2009
Texas A&M University
2004
Highlights•Self-resolved viremia is uncommon when CMV DNA levels reach the ≥150 IU/mL cutoff.•Duration of shorter starting preemptive therapy at <350 IU/mL.•Starting does not increase risk cytopenias.•Eradication by treatment day 35 associated with reduced NRM.•Refractory a high mortality rate after HCT.AbstractThe optimal viral load threshold which to initiate cytomegalovirus (CMV) in hematopoietic cell transplantation (HCT) recipients remains be defined. In an effort address this question,...
Reduced-intensity conditioning (RIC) regimens have the potential to decrease transplantation-related morbidity and mortality. However, engraftment failure has been prohibitively high after RIC unrelated umbilical cord blood transplantation (UCBT) in chemotherapy-naïve children with nonmalignant diseases (NMD). Twenty-two a median age of 2.8 years, many severe comorbidities prior viral infections, were enrolled novel protocol consisting hydroxyurea, alemtuzumab, fludarabine, melphalan,...
Cytomegalovirus (CMV) reactivation is a major complication among seropositive allogeneic hematopoietic cell transplantation recipients; however, data on CMV after chimeric antigen receptor (CAR) T-cell therapy are limited. We report the incidence and outcomes of 95 adult CMV-seropositive patients who received CAR between February 2018 2023. were (any viremia) clinically significant infection (cs-CMV). Thirty-one (33%) had evidence viremia), 10 (11%) cs-CMV. The median time from infusion to...
Genotoxic stress triggers the p53 tumor suppressor network to activate cellular responses that lead cell cycle arrest, DNA repair, apoptosis or senescence. This functions mainly through transactivation of different downstream targets, including inhibitor p21, which is required for short-term arrest long-term senescence, proapoptotic genes such as upregulated modulator (PUMA) and Noxa. However, mechanism switches from still unknown. In this study, we found mice harboring a hypomorphic mutant...
Following the advent of molecular assays that measure T cell receptor excision circles (TRECs) present in recent thymic emigrants, it has been conclusively shown thymopoiesis persists most adults, but functional output decreases with age, influencing maintenance a diverse and (TCR) repertoire. Space flight to result variety phenotypic changes human cells reactivation latent viruses. While space influence architecture rodents, not previously assessed astronauts. Here, we longitudinally over...
Allogeneic hematopoietic stem cell transplantation (aHSCT) can cure patients with otherwise fatal leukemias and lymphomas. However, the benefits of aHSCT are limited by graft-versus-host disease (GVHD). Minnelide, a water-soluble analog triptolide, has demonstrated potent antiinflammatory antitumor activity in several preclinical models proven both safe efficacious clinical trials for advanced gastrointestinal malignancies. Here, we tested effectiveness Minnelide preventing acute GVHD as...
Background Chimeric antigen receptor (CAR) T cell therapy is FDA-approved for the treatment of refractory or multiple-relapsed CD19+ B-NHL. Despite its ability to induce rapid and durable responses, it carries risk significant toxicities including cytokine release syndrome (CRS) reversible encephalopathy. There have been reports bone marrow failure after engineered-T cellular immunotherapy, however, no such exist CAR-T cells. Here, we report persistent cytopenias (PCTT) following...
The present studies examined experimental transplant outcomes using mobilized peripheral blood from mice and humans together with FoxP3+Treg cells. Donor were treated filgrastim / or plerixafor their (PB) displayed significant elevations in hematopoietic stem progenitor populations. Some of these PB donors concurrently administered a Treg expansion strategy consisting TL1A-Ig fusion protein low dose rIL-2. A increase (4-5x) the frequency Tregs occurred during mobilization. C3H.SW was...
Peptide vaccination against tumor-associated antigens remains one of the most common methods immunization in cancer vaccine clinical trials. Although peptide has been reported to increase circulating antigen-specific T-cells, they have had limited efficacy and there is a necessity their capacity generate strong antitumor responses. We sought improve peptide-based vaccines immunotherapy metastatic melanoma using LHRH agonist (leuprolide) as adjuvant. Seventy HLA-A*0201 stage IIb-IV patients...