A5070311506- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Hematopoietic Stem Cell Transplantation
- Palliative Care and End-of-Life Issues
- Pelvic and Acetabular Injuries
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Cervical and Thoracic Myelopathy
- Mobile Health and mHealth Applications
- Sarcoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Cancer survivorship and care
- Polyomavirus and related diseases
- Spinal Dysraphism and Malformations
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Hip and Femur Fractures
- Cytomegalovirus and herpesvirus research
- Computational Drug Discovery Methods
- Gut microbiota and health
Duke Medical Center
2019-2025
Duke University
2017-2024
Duke University Hospital
2020-2024
INTRODUCTION: Double Crush Syndrome (DCS) involves impingement at a proximal and distal site along single nerve. While extensively studied in the upper extremity, DCS lower extremity remains under-investigated. Reported incidence rates among patients with symptoms range from 6.7% to 73%, while there is no reported rate for extremity. As such, face uncertainty when facing potential diagnosis of DCS, which may lead delays treatment increased costs. METHODS: A retrospective cohort study was...
Hematopoietic stem cell transplantation (HCT) is a curative treatment option for patients with hematologic conditions but presents many complications that must be managed as complex, chronic condition. Mobile health applications (mHealth apps) may permit tracking of symptoms in HCT. In seeking strategies to manage the complexities HCT, our team collaborated Sicklesoft, Inc., develop an mHealth app specifically HCT allow daily evaluation patient health, Technology Recordings better Understand...
Minimally invasive spine surgery (MISS) has the potential to further advance with use of robot-assisted (RA) techniques. While RA pedicle screw placement been extensively investigated, there is a lack literature on robot for other tasks, such as accessing Kambin's triangle in percutaneous lumbar interbody fusion (percLIF).To characterize surgical feasibility and preliminary outcomes an initial case series 10 patients receiving percLIF cage via triangle.We performed single-center,...
Patients undergoing allogeneic (allo) and autologous (auto) hematopoietic cell transplantation (HCT) require extensive hospitalizations or daily clinic visits for the duration of their transplantation. Home HCT, wherein patients live at home providers make trips to patient's residence perform assessments deliver any necessary interventions, may enhance patient quality life improve outcomes. We conducted first study HCT in United States evaluate this model US healthcare setting determine...
Gastrointestinal (GI) complications including graft-versus-host disease (GVHD) are a major cause of morbidity and mortality in allogenic stem transplant recipients. Although several studies have previously looked into the acute GI complications, fewer smaller reported late complications. In this large study we focus on (100 days post-transplant) single-center, retrospective all adult cell recipients who had their at Duke University over 6-year period, 479 patients underwent transplant, whom...
Given the high symptom burden and complex clinical decision making associated with a diagnosis of brain metastases (BM), specialty palliative care (PC) can meaningfully improve patient quality life. However, no prior study has formally evaluated patient-specific factors PC consultation among BM patients.We examined rates consults in cohort 1303 patients admitted to three tertiary medical centers from October 2015 December 2018. Patient demographics, surgical status, 30-day readmission, death...
Retrospective review of prospective, multicenter and international cohort study.To describe the effect gender on HRQoL, clinical outcomes survival for patients with spinal metastases treated either surgery and/or radiation.Gender differences in health-related are demonstrated numerous studies, women experiencing worse receiving lower standards care than men, however, influence that has low quality life (HRQoL) after spine remains unclear.Patient demographic data, overall survival, treatment...
Spinal column tumors can be difficult to process for single-cell omic studies, given the heterogeneity in tissue. Here, we present a protocol operating room-to-benchtop processing of clinical specimens from prostate cancer patient. We describe steps sample homogenization, red blood cell lysis, cryopreservation, and sequencing analysis. This used identify prognostic markers therapeutic targets patients with osseous spine metastases better inform eligibility trials.
Cytomegalovirus (CMV) results in significant morbidity and mortality following hematopoietic cell transplantation (HCT). Establishing the cost clinical impact is imperative to selection of appropriate CMV preventative strategies. This a retrospective cohort study consecutive patients undergoing their first allogeneic HCT between January 1, 2009, December 31, 2013. Detailed institutional data were obtained from start conditioning through 1-year post-transplantation. Baseline characteristics,...
Abstract Background Few studies have assessed the impact of race on short-term patient outcomes in brain metastasis population. The goal this study is to evaluate association with inpatient clinical presentation, treatment, in-hospital complications, and mortality rates for patients metastases (BM). Method Using data collected from National Inpatient Sample between 2004 2014, we retrospectively identified adult a primary diagnosis BM. Outcomes included nonroutine discharge, prolonged length...
OBJECTIVE In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to higher level care must be weighed against negative effects associated potential delays in treatment. While association and status has been examined other specialties, relationship between status, complications, risk mortality MSD yet explored. The purpose this study was examine on in-hospital diagnosed MSD. METHODS...
Patients with oncologic spine disease face a high systemic illness burden and often require surgical intervention to alleviate pain maintain stability. Wound healing complications are the most common reason for reoperation in this population known impact quality of life initiation adjuvant therapy. Prophylactic muscle flap (MF) closure is reduce wound high-risk patients; however, efficacy patients not well established.
Abstract BACKGROUND Despite changes in national policy, women and minority patients remain under-accrued glioma clinical trials. Supervised machine learning may serve as a novel approach to understanding which variables their complex interplay most influence enrollment for underrepresented patients. We aimed design externally validate models predict therapeutic trial a) all patients, b) women, c) NIH-designated with low- high-grade glioma. METHODS In 20-year retrospective cohort of 1042...
Prognostic indices for patients with brain metastases (BM) are needed to individualize treatment and stratify clinical trials. Two frequently used tools estimate survival in BM the recursive partitioning analysis (RPA) diagnosis-specific graded prognostic assessment (DS-GPA). Given recent advances therapies improved BM, this study aims validate analyze these 2 models a modern cohort.