A5071878313- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Photodynamic Therapy Research Studies
- Advanced Radiotherapy Techniques
- Infrared Thermography in Medicine
- Trigeminal Neuralgia and Treatments
- Cerebral Venous Sinus Thrombosis
- Cancer Treatment and Pharmacology
- Management of metastatic bone disease
- Ocular Oncology and Treatments
- Patient-Provider Communication in Healthcare
- Social Media in Health Education
- Patient Satisfaction in Healthcare
- Fetal and Pediatric Neurological Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Heat shock proteins research
- Intracranial Aneurysms: Treatment and Complications
- Dermatologic Treatments and Research
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
Duke Medical Center
2021-2024
Duke University
2021-2024
Duke University Hospital
2021-2024
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
University of California, Davis
2020-2021
Neurological Surgery
2020-2021
Oxford University Press (United Kingdom)
2020
Abstract Brain extraction, or skull-stripping, is an essential data preprocessing step for machine learning approaches to brain MRI analysis. Currently, there are limited extraction algorithms the neonatal brain. We aim adapt established deep algorithm automatic segmentation of brains from MRI, trained on a large multi-institutional dataset improved generalizability across image acquisition parameters. Our model, ANUBEX (automated nnU-Net extractor), was designed using and subset...
INTRODUCTION: Laser interstitial thermal therapy (LITT) is used to treat radiographically progressive brain metastases following stereotactic radiosurgery (SRS), while resection has been reserved for large, symptomatic lesions in the upfront setting. Resection-associated morbidity eloquently-located may hinder definitive management. METHODS: Patients receiving or LITT associated with primary motor cortex (PMC) from 2015-2023 were retrospectively reviewed. Clinicodemographic and survival data...
INTRODUCTION: Laser interstitial thermal therapy (LITT) allows for confirmatory tissue diagnosis, surgical cytoreduction, and faster return to systemic therapies patients with brain tumors or radiation necrosis. Ablated remains in situ following LITT, post-LITT edema potentially associated transient clinical worsening complicating subsequent response assessment. METHODS: All receiving LITT at a single center necrosis from 2015 – 2023 = 9 months of MRI follow-up were retrospectively reviewed....
OBJECTIVE The traditional freehand placement of an external ventricular drain (EVD) relies on empirical craniometric landmarks to guide the craniostomy and subsequent passage EVD catheter. diameter trajectory physically limit possible trajectories that can be achieved during In this study, authors implemented a mixed reality–guided procedure evaluate benefit optimally drilled accurate METHODS Optical marker–based tracking using OptiTrack system was used register brain hologram drilling...
Abstract Background Laser interstitial thermal therapy (LITT) of intracranial tumors or radiation necrosis enables tissue diagnosis, cytoreduction, and rapid return to systemic therapies. Ablated remains in situ, resulting characteristic post-LITT edema associated with transient clinical worsening complicating response assessment. Methods All patients receiving LITT at a single center for from 2015 2023 ≥9 months MRI follow-up were included. An nnU-Net segmentation model was trained...
OBJECTIVE Meningiomas are the most common primary brain tumors in adults and a subset aggressive lesions resistant to standard therapies. Laser interstitial thermal therapy (LITT) has been successfully applied other tumors, recent work aims explore safety long-term outcome experiences of LITT for both new recurrent meningiomas. The authors’ objective was report outcomes data largest cohort LITT-treated meningioma patients date. METHODS Eight United States–based hospitals enrolled with...
Patients increasingly utilize online physician review websites (PRWs) and social media to inform healthcare-related decisions. This provides neurosurgeons with opportunities for increased patient engagement. And despite the growing use of among neurosurgeons, relationship between utilization reviews remains unknown. The goal this study was characterize PRW ratings across academic neurosurgery departments.Social accounts (Twitter, Facebook, YouTube, Instagram) departments were identified....
BACKGROUND: The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal therapy (LITT) represents novel treatment for local control brain tumors through photocoagulation with stereotactically implanted laser fiber. Because the use continues to increase within neurosurgery, characterization LITT is necessary improve outcomes. OBJECTIVE: To quantify risk tumor seeding along fiber tract patients...
Abstract Purpose: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within tumors and amplify the ablative capacity of LITT. Experimental Design: The impact GNS on LITT coverage was tested in ex vivo models using clinical equipment agarose gel–based phantoms control GNS-infused central “tumors.” In accumulation amplification...
Background: Meningiomas are the most common primary central nervous system neoplasm in United States. While majority of meningiomas benign, World Health Organization (WHO) Grade I tumors, a not-insignificant proportion tumors anatomically complex locations or demonstrate more aggressive phenotypes, presenting challenge for local disease control with surgery and radiation. Laser interstitial thermal therapy (LITT) consists stereotactic delivery laser light tumor ablation is minimally...
INTRODUCTION: Meningiomas are a common central nervous system tumor, and subset aggressive lesions resistant to standard therapies. Laser interstitial thermal therapy (LITT) has been successfully applied other brain tumors, but its role in meningioma treatment is understudied. METHODS: Eight United States-based hospitals enrolled patients with the prospective multicenter registry pooled additional retrospective enrollments for this cohort study. Demographics, procedural, safety, outcomes...
Abstract BACKGROUND Despite changes in national policy, women and minority patients remain under-accrued glioma clinical trials. Supervised machine learning may serve as a novel approach to understanding which variables their complex interplay most influence enrollment for underrepresented patients. We aimed design externally validate models predict therapeutic trial a) all patients, b) women, c) NIH-designated with low- high-grade glioma. METHODS In 20-year retrospective cohort of 1042...
INTRODUCTION: Cytoreductive surgery is a cornerstone of management for intracranial tumors. However, such treatment may remove an important source neoantigen. In the case laser interstital thermal therapy (LITT), thermally-ablated tumor remans in situ, allowing potential anti-tumor immune response. METHODS: Brain cell lines (CT-2A) were stereotactically implanted into C57BL/6 mice. A 1064 nm Nd:YAG (Neuroblate, Monteris Medical) was used to ablate normal brain and tissue. RESULTS: To...
INTRODUCTION: Immune checkpoint blockade (ICB) has gained acceptance as a life-extending therapy in variety of solid tumor types. For patients with brain metastases, combination stereotactic radiosurgery (SRS) and ICB remains an area clinical equipoise. Similarly, for recurrent or difficult-to-access intracranial lesions, safety synergy laser interstitial thermal (LITT) yet to be explored. METHODS: In accordance IRB-approved protocol, all undergoing LITT at tertiary center from 2015-2022...
Abstract BACKGROUND Laser interstitial thermal therapy (LITT) has clinical utility in treating radiographically progressive brain metastases (BM) following stereotactic radiosurgery (SRS), while resection been reserved for large, symptomatic lesions the upfront setting. Resection-associated morbidity eloquently-located may hinder definitive management. METHODS Patients receiving or LITT BM associated with primary motor cortex (PMC) from 2015-2023 were retrospectively reviewed....
Abstract OBJECTIVE Laser interstitial thermal therapy (LITT) is a minimally invasive option for the management of intracranial pathologies, including radiographically progressive tumors following stereotactic radiosurgery. Although LITT has been increasingly accepted in recent years, little known regarding presentation and outcomes patients with diverse backgrounds, particularly centers specializing central nervous system (CNS) metastases. METHODS All receiving their index brain metastasis...
Abstract Stereotactic radiosurgery (SRS) is the standard of care for initial management brain metastases (BM) and provides excellent local control with reduced incidence adverse neurocognitive effects. However, radiographically progressive lesions post-SRS pose a key clinical challenge, as imaging characteristics cannot effectively distinguish between recurrence (LR) radiation necrosis (RN). A retrospective analysis was performed on patients receiving SRS treatment BM 2011-2022 who...