A5090238569- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Spine and Intervertebral Disc Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Myofascial pain diagnosis and treatment
- Cardiovascular Syncope and Autonomic Disorders
- Epilepsy research and treatment
- Health disparities and outcomes
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Health Policy Implementation Science
- Innovations in Medical Education
Duke University
2019-2024
Duke University Hospital
2019-2024
Duke Medical Center
2019-2024
ORCID
2023
Clinical Research Institute
2022
Oxford University Press (United Kingdom)
2020-2021
Bridge University
2021
University of Puerto Rico at Carolina
2021
Duke University Health System
2020
To quantify health care resource utilization and risk of complications in painful diabetic peripheral neuropathy (pDPN).Adult patients diagnosed with diabetes mellitus or (DPN) were identified MarketScan from January 2010 to December 2015. Subgroups (pDPN nonpainful DPN) based on the use pain medications 6 months before a new indexed diagnosis 1 year thereafter. Health costs collected for up 5 years, charted those at least 2 years follow-up. Complication comparisons made using χ2 Fisher...
In Brief Study Design. Retrospective analysis of inpatient and outpatient medical insurance claims data from a database containing >100 million individuals. Objective. The aim this study was to quantify the health care resource utilization (HCRU) nonsurgical treatments in first 2 years after chronic, refractory low back pain (CRLBP) diagnosis. Summary Background Data. Patients with persistent (LBP) despite conventional management who are not candidates for spine surgery considered have CRLBP...
Objectives/Goals: In 2018, a novel analytic resource navigation process was developed at Duke University to connect potential collaborators, leverage resources, and foster community of quantitative researchers scientists. We provide information about how this works along with guidance for academic medical centers develop similar initiatives. Methods/Study Population: Quantitative qualitative scientists expertise in data science, biostatistics, epidemiology, related fields play critical role...
Abstract BACKGROUND Opioid misuse in the USA is an epidemic. Utilization of neuromodulation for refractory chronic pain may reduce opioid-related morbidity and mortality, associated economic costs. OBJECTIVE To assess impact spinal cord stimulation (SCS) on opioid dose reduction. METHODS The IBM MarketScan® database was retrospectively queried all US patients with a diagnosis undergoing SCS between 2010 2015. usage before after procedure quantified as morphine milligram equivalents (MME)....
<h3>Background</h3> There has been heightened interest in performing percutaneous lumbar interbody fusions (percLIFs) through Kambin's triangle, an anatomic corridor allowing entrance into the disc space. However, due to its novelty, there are limited data regarding long-term benefits of this procedure. Our objective was determine efficacy and durability insertion expandable titanium cage triangle without facetectomy. <h3>Methods</h3> A retrospective review patients undergoing percLIF via...
OBJECTIVE Deep brain stimulation (DBS) is a well-established treatment for Parkinson’s disease (PD) and essential tremor (ET). Although the prevalence of PD ET can vary by sex race, little known about accessibility neurosurgical treatments these conditions. In this nationwide study, authors aimed to characterize trends in use DBS identify disparities diseases based on ethnic, racial, sex, insurance, income, hospital, geographic factors. METHODS Using dates January 1, 2012, December 31, 2019,...
To evaluate radiation exposure and image quality (IQ) for 3 intraoperative imaging systems (Airo TruCT, Cios Spin, O-arm) using varying dose settings in a single cadaveric model.Axial images of L4-5 instrumentation were obtained manufacturer protocols each system. Measurements included scattered dose, subjective objective IQ, estimates patient effective (ED). Four per system selected at level. Using the Likert scale (1 = best, 5 worst), 9 reviewers rated same 36 images. Objective IQ measures...
There is a profound need to identify modifiable risk factors screen and prevent pancreatic cancer. Air pollution, including fine particulate matter (PM2.5), increasingly recognized as factor for We conducted case-control study using data from the electronic health record (EHR) of Duke University Health System, 15-year residential history, NASA satellite (PM2.5) neighborhood socioeconomic data. Using deterministic probabilistic linkage algorithms, we linked history EHR quantify long term...
Essential tremor (ET) is a movement disorder that affects 4%-5% of adults >65 years. For patients with medically refractory ET, neurosurgical interventions such as deep brain stimulation (DBS) and unilateral MR-guided focused ultrasound thalamotomy (MRgFUS) are available. In this retrospective cohort study, we examined the demographics ET who have received MRgFUS evaluated trends in DBS usage USA after introduction 2016.
Tacrolimus remains the mainstay of immunosuppression in kidney transplantation. Understanding relationship between therapeutic tacrolimus levels and outcomes acute rejection, patient/graft survival, tolerability are important. The time to has not been well established, specifically with use extended release formulation (LCP-Tac). This study investigated 2 formulations, LCP-Tac immediate (IR-Tac), as a predictor clinical outcomes.
Nontraumatic, primary intracerebral hemorrhage (ICH) accounts for 2 million strokes worldwide annually and has a 1-year survival rate of 50%. Recent studies examining functional outcomes from ICH evacuation have been performed, but limited work done quantifying the incidence subsequent complications their healthcare economic impact. The purpose this study was to quantify resource utilization (HCRU) major that can arise ICH.
Traumatic spinal cord injury (SCI) is a serious public health problem. Outcomes are determined by severity of immediate injury, mitigation secondary downstream effects, and rehabilitation. This study aimed to understand how the center type patient presents whether they transferred influence management outcome.
Abstract This manuscript describes an experiential learning program for future collaborative biostatisticians (CBs) developed within academic medical program. The is a effort between the Biostatistics, Epidemiology, and Research Design (BERD) Methods Core Master of Biostatistics (MB) programme, both housed in Department Bioinformatics at Duke University School Medicine supported partnership with Clinical Translational Science Institute. To date, BERD Training Internship Program (BCTIP) has...
Translational research is a data-driven process that involves transforming scientific laboratory- and clinic-based discoveries into products activities with real-world impact to improve individual population health. Successful execution of translational requires collaboration between clinical science researchers, who have expertise in wide variety domains across the field medicine, qualitative quantitative scientists, specialized methodologic diverse domains. While many institutions are...
Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, impact of congenital HCMV (cCMV) on transfer has been underexplored.We evaluated total and antigen-specific cord blood levels efficiency a US-based cohort 93 mother-infant pairs including 27 cCMV-infected...
Background: Quetiapine is an atypical antipsychotic that commonly used in the Intensive Care Unit (ICU). The utility of quetiapine as a sedative adjunct has not yet been evaluated, but described previously studies evaluating for delirium or prophylaxis. Objective: To determine if adjunctive use reduces dosage requirements among mechanically ventilated adults without delirium. Methods: This retrospective intrapatient comparator study included all admitted to medical ICU who received between...