A5031850022- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Liver Disease and Transplantation
- Cervical and Thoracic Myelopathy
- Peroxisome Proliferator-Activated Receptors
- Muscle and Compartmental Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- CAR-T cell therapy research
- Parasites and Host Interactions
- Congenital limb and hand anomalies
- Cerebrovascular and Carotid Artery Diseases
- Oral and Maxillofacial Pathology
- Dialysis and Renal Disease Management
- Emergency and Acute Care Studies
- Viral gastroenteritis research and epidemiology
- Helminth infection and control
- Radiation Dose and Imaging
- Surgical Sutures and Adhesives
- Spinal Cord Injury Research
- Hemoglobinopathies and Related Disorders
- Drug-Induced Hepatotoxicity and Protection
Prince Sultan University
2024
Tanta University
2009-2023
Al-Azhar University
2023
Duke Medical Center
2010-2021
Duke University Hospital
2018-2021
Neurological Surgery
2021
Bridge University
2021
University of Puerto Rico at Carolina
2021
RELX Group (Netherlands)
2019
Duke University
2009-2019
Interleukin-17 (IL-17) is a cytokine recently shown to be elevated, along with interferon-γ (IFNγ) and tumor necrosis factor (TNFα), in degenerated herniated intervertebral disc (IVD) tissues, suggesting role for these cytokines disease. The objective of our study was investigate the involvement IL-17 costimulants IFNγ TNFα pathology. Cells were isolated from anulus fibrosus nucleus pulposus tissues patients undergoing surgery degeneration or scoliosis. production inflammatory mediators,...
Abstract Introduction Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both patients. The objective of this study describe spatiotemporal ground reaction force changes a rat medial meniscus transection (MMT) model knee compare these gait measures with assays weight bearing tactile allodynia. Methods Sixteen rats were the study. collateral ligament (MCL) was transected twelve...
There has been an increased interest in lumbar interbody fusions through Kambin's triangle. In this study, we describe percutaneous access to the disc and insertion of expandable titanium cage triangle without facetectomy. The objective study is determine feasibility as well clinical radiographical outcomes completely fusion (percLIF) using triangle.A retrospective review patients undergoing single-level percLIF for grade 1 spondylolisthesis via was performed. Demographic information,...
Abstract Introduction Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that antagonists can attenuate heightened nociception resulting from radiculopathy the preclinical model. Less is known about potential impact on gait compensations, despite being clinical relevance. In this study, we expand previous descriptions compensations rat and describe...
Chordoma cells can generate solid-like tumors in xenograft models that express some molecular characteristics of the parent tumor, including positivity for brachyury and cytokeratins. However, there is a dearth markers relate to chordoma tumor growth, as well cell lines needed advance treatment. The objective this study was isolate novel primary source analyze growth mouse model comparison with established U-CH1 U-CH2b lines.Primary from sacral chordoma, called "DVC-4," were cultured...
ABSTRACT The relationship between impaired calcium sensing, dysregulated parathyroid hormone (PTH) secretion, and cell proliferation in neoplasia is not understood. We previously reported that a GTPase activating protein, regulator of G-protein signaling 5 (RGS5) overexpressed subset tumors associated with primary hyperparathyroidism (PHPT) RGS5 can inhibit from the calcium-sensing receptor (CASR). In vivo, we found RGS5-null mice have abnormally low PTH levels. To gain better understanding...
Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, even midbrain, have been documented in rat models of radiculopathy or nerve injury. The objective this study was evaluate gait expression key receptors midbrain a rodent model radiculopathy. Radiculopathy induced by harvesting tail nucleus pulposus (NP) placing upon right L5 DRG rats...
Traumatic spinal cord injury (SCI) is a serious public health problem. Outcomes are determined by severity of immediate injury, mitigation secondary downstream effects, and rehabilitation. This study aimed to understand how the center type patient presents whether they transferred influence management outcome.
Children with thalassaemia major may be kept alive by repeated blood transfusion.Even then they die later from intractable cardiac failure, liver cirrhosis, or diabetes mellitus, due to excess deposition of iron in various organs (Engle, 1964).Venesection, at frequent intervals, was tried many years ago overcome this difficulty.Despite its beneficial effects, venesection imposes a severe strain on the already anaemic patient.Attempts reduce amount absorbed intestine proved failure...
It was observed that type II diabetes mellitus associated with chronic liver failure improved after stem cell transplantation. However, there were no adequate studies regarding this issue. The aim of study to evaluate the effect transplantation on and function tests.This pilot included 30 patients post-hepatitis who classified into two groups: Group I 2 diabetes. without Autologous CD34+ CD133+ cells percutaneously infused portal vein. Responders (regarding improvement as well condition)...
Summary: This case report details the challenging management of a 3-year-old girl with severe left-hand extension contracture resulting from scald burn. Delayed presentation prompted 2-stage surgical approach. The first stage involved excising contracted skin and using groin flap for reconstruction. Two weeks later, donor site closure was performed. patient later underwent syndactyly release extensor tenotomy, achieving significant metacarpophalangeal proximal interphalangeal joint flexion....
Background: The biologic mechanisms that differentiate successful arteriovenous fistula (AVF) maturation from stenosis are not well understood. brachiobasilic transposition offers an opportunity for studying the vascular remodeling process. This procedure is a two stage process: first to create AVF and second, transpose near skin in delayed fashion, allowing harvest naïve vein, mature stenotic tissue. Identifying molecular differences with regards success (maturation) or failure (stenosis)...
Background: Hemodialysis patients routinely employ relative blood volume (RBV) monitoring to direct fluid management and enhance cardiovascular stability, Aim: In order determine how estimates of changes may vary based on the method, current study sought examine in hematocrit, haemoglobin, or total protein concentration receiving normal maintenance hemodialysis. Subject Methods: This was a prospective cross-sectional curried out at Nephrology Departments Al Hussien University Hospitals Ahmed...
Background: Recently, it has been recognized that non-alcoholic fatty liver disease (NAFLD) represents an important burden of for patients with type 2 diabetes mellitus (DM).those individuals not only have a high prevalence NAFLD but also seem to increased severity the disease.Therefore, is very diagnose early and manage properly in primary stage which will enhance prognosis prevent secondary complications.Objective: The present study aimed evaluate role neck circumference (NC) as predictive...
Abstract Background. Disulfiram (DSF), a carbamate derivative and potent aldehyde dehydrogenate inhibitor, is used clinically to treat alcoholism. Although, relatively nontoxic, DSF exhibits significant anticancer effects, when administered with heavy metals (Cu Zn). Because of this the fact that crosses blood-brain barrier, being investigated as potential agent for brain tumor therapy. In previous study, we showed that, in glioblastoma (GBM) cells, copper-DSF complex inhibited activity DNA...