A5039507593- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Whipple's Disease and Interleukins
- Helicobacter pylori-related gastroenterology studies
- Hepatitis Viruses Studies and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Galectins and Cancer Biology
- Parathyroid Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Respiratory viral infections research
- T-cell and Retrovirus Studies
- TGF-β signaling in diseases
- Animal Virus Infections Studies
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Estrogen and related hormone effects
Kiyatec (United States)
2024
Washington University in St. Louis
2024
University of Maryland, Baltimore
2016-2021
Shahid Beheshti University of Medical Sciences
2012-2021
Biotechnology Research Center
2016
Academic Center for Education, Culture and Research
2016
Shahid Beheshti University
2013-2015
Aja University of Medical Sciences
2011
Hepatitis A virus (HAV) and hepatitis E (HEV) are enteric hepatotropic viruses their prevalence is related to the sanitary conditions of region under investigation. There only a few studies on seroepidemiology these two in general Iranian population. The purpose this investigation was measure infections Between 2006 2007, cross sectional study performed Tehran, Iran. Blood specimens were collected questionnaires filled for 551 persons. Patient sera tested by ELISA anti-HEV anti-HAV IgGs....
Crohn's disease (CD) and ulcerative colitis (UC) are types of chronic inflammatory bowel (IBD) which the actual causes remain unknown. Emerging data indicate that alterations in cytokine synthesis may be involved IBD pathogenesis. The aim present study was to determine whether tumor necrosis factor (TNF)‑α mRNA expression level rs1799964 polymorphism genetic susceptibility component development. TNF‑α peripheral blood mononuclear cells (PBMCs) measured using comparative reverse‑transcription...
The influence of microsatellite instability (MSI) on the prognosis colorectal cancer (CRC) requires more investigation. We assessed role MSI status in survival individuals diagnosed with primary cancer. In this retrospective cross-sectional study was determined 158 formalin-fixed paraffin-embedded tumors and their matched normal tissues from patients who underwent curative surgery. Cox proportional hazard modeling performed to assess clinical prognostic significance. we found that MSI-H were...
Abnormal feedback of serum calcium to parathyroid hormone (PTH) secretion is the hallmark primary hyperparathyroidism (PHPT). Although molecular pathogenesis neoplasia in PHPT has been linked abnormal expression genes involved cell growth (e.g., cyclin D1, retinoblastoma, and β-catenin), basis sensing by calcium-sensing receptor (CaSR) PTH hypersecretion are incompletely understood. Through gene profiling, we discovered that an orphan adhesion G protein-coupled (GPCR), GPR64/ADGRG2,...
Gastric cancer (GC) is the second cause of cancer-related death worldwide. Interleukin (IL)-16 has a vital role in development and homeostasis immune system. In present study, we evaluated an exon variant rs4072111 C/T polymorphism 3' UTR rs1131445 within miRNA binding with gastric susceptibility Iranian population. Genomic DNA was isolated from peripheral blood samples according to phenol chloroform extraction. The genotypes IL-16 polymorphisms T/C were determined by polymerase chain...
Host genetic background is known as an important factor in patients’ susceptibility to infectious diseases such viral hepatitis. The aim of this study was determine the effect polymorphisms interleukin-16 (IL-16) cytokine on hepatitis B virus (HBV) infected patients develop chronic HBV infection. Genotyping conducted using PCR followed by enzymatic digestion and RFLP (restriction fragment length polymorphism) analysis. We genotyped three single nucleotide (SNPs) Il-16 gene (rs11556218...
Abstract Hepatitis B virus (HBV) isolates from Iranian patients around the country were characterized. Eighty‐one complete genomes HBV sequenced and analyzed. The studied population was grouped into three categories including inactive carriers, with chronic hepatitis, liver cirrhosis. Molecular phylogenetic analyses revealed that infected genotype D subgenotype D1. most common subtype ayw2 , followed by ayw3 ayw4 . Several deletions insertions had no correlation disease outcome observed in...
Abstract Mechanisms of activation, signaling, and trafficking adhesion G protein–coupled receptors (aGPCRs) have remained largely unknown. Several aGPCRs, including GPR56/ADGRG1 GPR64/ADGRG2, show increased activity in the absence their N‐terminal fragment (NTF). This constitutive signaling is plausibly caused by binding extracellular 15–25 amino acid–long tethered agonist to domains cognate aGPCRs. To test role NTF GPR64 endocytosis, we generated mutants that lack either alone (ΔNTF) or...
Interleukin-16 (IL-16) is a multifunctional pro-inflammatory cytokine that was previously found in association with complex disorders, and it now cleared this plays critical role regulation of cellular functions such as homoeostasis. Due to the complexity endometriosis its resemblance cancer, we designed present case-control study determine effects genetic polymorphisms human IL-16 gene on Iranian women's susceptibility endometriosis. A total 126 patients (stages I-IV) 144 healthy women...
Helicobacter pylori (H. pylori) infection is now recognized as a worldwide problem. CagA the first bacterial oncoprotein to be identified in relation human cancer. noted for structural diversity its C-terminal region (contains EPIYA motifs), with which interacts numerous host cell proteins. Deregulation of signaling by translocated proteins provides new aspect microbial–host interaction. The aim this study compare cellular effects two different motifs on pathways involve gastric...
Chronic hepatitis C infection is caused by the virus (HCV), and its clinical complications include liver cirrhosis, failure, hepatocellular carcinoma.Transforming growth factor-β1 (TGF-β1) an important cytokine in cell growthand differentiation, angiogenesis, extracellular matrix formation, immune responseregulation, cancer development progression.The aim of this study was to investigate relationship between single nucleotide polymorphisms (SNPs) TGF-β1 chronic HCV among patients referred...
Hepatitis C virus (HCV) has infected approximately 170 million people worldwide. While the seroprevalence of anti-HCV antibody among Iranian blood donors is 0.13%, HCV infection prevalent in 59-80% injecting drug users. One hundred seventy-eight positive patients were referred to Gastroenterology Department at Taleghani Hospital (Tehran, Iran) between June 2007 and 2012. Out 178 samples, 142 for HCV-RNA. subtypes determined using phylogenetic analysis NS5B or 5'UTR/core regions. Of viremic...
Colorectal cancer (CRC) is the fourth most common cause of death in world. Genetic variants 8q24.21 including rs10505477 and rs6983267 have been hypothesized to be involved susceptibility CRC. This study aims investigate possible association between these loci their haplotypes with CRC risk Iranian population.Subjects were recruited from two hospitals Tehran. The polymorphisms genotyped by TaqMan real time PCR using subject genomic DNA, extracted either formalin-fixed, paraffin-embedded...
Abstract Association of the severity Helicobacter pylori induced diseases with virulence entity colonized strains was proven in some studies. Urease has been demonstrated as a potent factor for H. . The main aim this study investigation relationships ure B sequence diversity, urease activity and genotypes different histopathological changes gastric tissue infected patients suffering from disorders. Analysis isolated indicated significant associations between presence severe active gastritis...