A5005083399- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Diabetic Foot Ulcer Assessment and Management
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Diabetes Management and Research
- Liver Disease and Transplantation
- Chronic Kidney Disease and Diabetes
- Selenium in Biological Systems
- Neurological Disorders and Treatments
- Diabetes Treatment and Management
- Advanced Glycation End Products research
- Skin Diseases and Diabetes
- Metabolomics and Mass Spectrometry Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Salivary Gland Disorders and Functions
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
Tanta University
2017-2024
Cairo University
2019
Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung architecture and function, resulting in severe respiratory failure death. It has no definite treatment. Empagliflozin (EMPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, protective potential PF. However, the mechanisms underlying these effects require further elucidation. Therefore, this study aimed to evaluate ameliorative effect of EMPA against bleomycin (BLM)-induced PF mechanisms. Twenty-four...
Background: Stress hyperglycemia is a common finding during ST elevation myocardial infarction in diabetic patients and associated with worse outcome. However, there are limited data about stress non-diabetic its outcome especially undergoing primary percutaneous coronary intervention. Methods: The study was conducted on 660 who were managed Patients classified into two groups according to the presence of hyperglycemia: group I (patients hyperglycemia) II without hyperglycemia). analysed for...
Abstract Background Chronic kidney disease (CKD) signifies a frequently life‐threatening condition influencing structure and function. Despite its irrefutable importance, exact pathogenesis is not completely clarified. However, CKD known to be associated with accumulated uremic toxins/metabolites, interstitial fibrosis, systemic inflammation. So we aimed investigate the role of microbiota‐dependent metabolite trimethylamine N ‐oxide (TMAO), transforming growth factor β (TGFβ)/SMAD signaling,...
Diabetic retinopathy (DR) signifies a frequent serious diabetic complication influencing retinal structure and function. Dysregulation of lncRNAs drives wide array human diseases especially diabetes; thus, we aimed to study lncRNA HIF1A-AS2 role its interplay with hypoxia, oxidative stress (OS), angiogenesis in DR.60 DM patients addition 15 healthy subjects. were enrolled. LncRNA mRNA relative gene expression was assessed. Hypoxia inducible factor 1-alpha (HIF-1α), vascular endothelial...
Diabetic nephropathy (DN) is one of the major causes end-stage renal disease. Nod-like receptors nucleotide-binding domain and leucine-rich repeat pyrin-3 (NLRP3) inflammasome displays a considerable role in chronic inflammatory state observed diabetic patients. Urinary heat shock protein 72 (uHSP72) sensitive specific biomarker for early detection acute kidney injury. The aim this study was to evaluate NLRP3 relative gene expression, its correlation with oxidative stress markers, assess...
Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It one of the commonly known causes drug-induced nephrotoxicity, results acute renal injury. Adrenomedullin (ADM), a vasodilator peptide, widely distributed many tissues and potent protective effects. Therefore, current study aimed to examine potential mechanisms ADM against DOX-induced nephrotoxicity. A total 28 male Wistar rats were randomized into four groups: control group, doxorubicin group (15...
The cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is human glucagon-like peptide-1 receptor agonist (GLP-1R), which used primarily for treatment DM. Various recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic antioxidant effects. current study aimed investigate...
Abstract Growing evidence supports the role of gut-kidney axis and persistent mitochondrial dysfunction in pathogenesis diabetic nephropathy (DN). Ulinastatin (UTI) has a potent anti-inflammatory effect, protecting kidney gut barrier sepsis, but its effect on DN yet to be investigated. This study aimed assess potential mitigating UTI investigate possible involvement homeostasis this effect. Forty male Wistar rats were divided equally into four groups: normal; UTI-treated control; untreated...
Abstract The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle adipose tissue the liver to integrate energy homeostasis under diet-induced obesity. We aimed explore putative role irisin in protection against postmenopausal rat model by modulating expenditure (EE). Bilateral ovariectomy (OVX) was performed. After 3 weeks...
Alcoholic liver disease (ALD) encompasses a variety of injuries with various underlying mechanisms but still no effective treatment. So we aimed to monitor the influence simvastatin on alcohol-induced injury and elucidate its cytoprotective effect. Thirty male albino rats were randomly divided into five equal groups. Group 1 (control): received standard diet; group 2: (10 mg kg-1 day -1 ) once orally for 8 weeks; 3: 20% ethanol (7.9 g kg daily 4: along same dose 5: weeks then next weeks....
Abstract Background Vascular calcification (VC) is a major predictor of cardiovascular diseases that represent the principal cause mortality among type-2 diabetic patients. Accumulating data suggest vital role some microRNAs on vascular as an epigenetic regulator. Thus, we assessed herein, serum miR-433-3p in Methods Twenty healthy subjects (control group) and forty patients (20 without VC 20 with VC) were involved study. gene expression was measured. Runx2, Dickkopf-1 (DKK1), β-catenin,...
Valproic acid (VPA) is a commonly used drug for management of epilepsy. Prolonged VPA administration increases the risk hepatotoxicity. Liraglutide glucagon-like peptide 1 receptor (GLP-1R) agonist that act as novel antidiabetic with broad-spectrum anti-inflammatory and antioxidant effects. This study tested protective effect liraglutide against VPA-induced hepatotoxicity elucidating possible underlying molecular mechanisms. Forty adult male rats were allocated in to four equally sized...
Abstract Normal gonadal function can be disrupted by hypothyroidism. Hypothyroidism disturbs testicular directly and centrally affecting the hypothalamic‐pituitary‐testicular axis with unclear mechanism. As nesfatin‐1 neurons co‐localized TRH GnRH in hypothalamus, it could play a role hypothyroidism induced dysfunction. Selenium (Se), thyroid iodide supply, relieve these disturbances. So, we aim to identify of as link between dysfunction through modulating MAPK/ERK pathway while discussing...
Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential adropin and/or tirzepatide (Tirze) on cardiometabolic aberrations letrozole-induced PCOS model. Female Wistar non-pregnant rats were allotted into five groups: CON; PCOS; + adropin; Tirze; adropin+ Tirze. The serum sex hormones, glucose, lipid profiles securitized. Cardiac...