A5027855119- Neonatal Respiratory Health Research
- Parasitic Diseases Research and Treatment
- Neonatal and fetal brain pathology
- Pesticide Exposure and Toxicity
- Parasites and Host Interactions
- Adipose Tissue and Metabolism
- Neonatal and Maternal Infections
- Parasite Biology and Host Interactions
- Curcumin's Biomedical Applications
- Selenium in Biological Systems
- Osteoarthritis Treatment and Mechanisms
- Reproductive Health and Contraception
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Ovarian function and disorders
- Asthma and respiratory diseases
- Congenital Heart Disease Studies
- Toxoplasma gondii Research Studies
- Congenital Diaphragmatic Hernia Studies
- Cerebrovascular and Carotid Artery Diseases
- Chemotherapy-induced organ toxicity mitigation
- Cancer Mechanisms and Therapy
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Peptidase Inhibition and Analysis
Tanta University
2016-2025
Alexandria University
2025
Suez Canal University
2025
Mayo Clinic in Arizona
2025
Tanta University Hospital
2023
Tufts University
2018
Jean Mayer Human Nutrition Research Center on Aging
2018
University of Miami
2018
Universität Hamburg
2018
Hamburg University of Technology
2018
Abstract Background In secondary Sjogren syndrome (sSS), the presence and extent of hearing vestibular abnormalities are controversial. Hence, to ascertain if individuals with Rheumatoid arthritis (RA) associated (sSS) had subclinical audio-vestibular impairment as well investigate whether serum anticardiolipin muscarinic receptors type 3 antibodies a role in its pathogenesis, this cross-sectional study was conducted on 50 RA patients manifestations without such were included, along...
Thiamethoxam (TMX), a widely used second-generation neonicotinoid insecticide, has raised concerns due to its toxic effects on non-target species, including mammals. Its prolonged use is associated with hepatotoxicity, nephrotoxicity, and reproductive damage. This study evaluates the dose-dependent biochemical, histopathological, genetic of TMX in male albino rats, emphasizing impact liver, kidney, systems. Forty Wistar rats were assigned control three experimental groups treated at 26, 39,...
Background: Total mesorectal excision (TME) remains the gold standard for resection of rectal cancer regardless modality: open, laparoscopic, or robotic. The transanal TME (TaTME) approach has been utilized to overcome difficulties encountered with dissection tumors in distal pelvis. Recently, a single-port robotic (rSPa) was introduced, where three arms and camera emanate from 2.5 cm diameter port. This report presents first experience United States combining those two approaches (rSPa...
Organophosphorus poisoning is a major global health problem with hundreds of thousands deaths each year. Research interest in N-acetylcysteine has grown among increasing evidence the role oxidative stress organophosphorus poisoning. We aimed to assess safety and efficacy as an adjuvant treatment patients acute This was randomized, controlled, parallel-group trial on 30 suffering from poisoning, who were admitted Poison Control Center Tanta University Emergency Hospital, Tanta, Egypt, between...
BACKGROUND: Birth asphyxia is a leading case of neonatal morbidity and mortality especially in developing countries. Hypoxic-ischemic encephalopathy (HIE) attributed to can be ameliorated with several remedies, although full recovery curr
Trichinellosis is a serious food-borne zoonotic infection of cosmopolitan distribution. Currently, treatment for trichinellosis far from ideal. Given the important role oxidative stress and immune-mediated inflammation in pathogenesis trichinellosis, this study was designed to evaluate possible protective effects resveratrol (RSV) during intestinal muscular phases Trichinella spiralis mice. The oral administration RSV at dose 20 mg/kg once daily two weeks resulted significant reductions both...
liver cancer is one of the most common cancers in world. So far, there no gold standard treatment for hepatocellular carcinoma. We conducted this vitro study to assess effect three natural products: Boswellic acids, curcumin and naringin versus corresponding nanoparticles (NPs) on Hep G2 cells proliferation.Boswellic acid, curcumin, naringin-loaded NPs were prepared using nanoprecipitation method. Human (HepG2) cell line was cultured Dulbecco's modified Eagle's medium (DMEM). The growth...
Liver cirrhosis is a scene profitable to the advance of hepatocellular carcinoma (HCC). The current work was engrossed weigh potential role Cichorium intybus linn against thioacetamide (TAA)-induced liver and their probable underlying biochemical molecular mechanisms. farnesoid-X-receptor (FXR) expression, proliferating cell nuclear antigen (PCNA) immunoreactivity, activated AMP protein kinase (pAMPK), sirtuin-1 (SIRT1), interleukin-6 (IL6) levels were estimated in hepatic tissue by...
This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration indomethacin (30 mg/kg). 50 male albino rats were allocated into 5 equal groups: control group received normal saline orally, orally for days and (50 mg/kg) on last day, ranitidine (reference drug) before receiving NAC groups at 300 500 mg/kg, respectively, day. Gastric tissue interleukin-1β (IL-1β),...
Varicocele is a leading cause of male infertility. Melatonin highly pleiotropic neurohormone. We aimed to characterize the melatonin epigenetic potential in varicocele and involved molecular mechanisms.Fifty-two albino rats were randomly divided into four groups (13 each): control (I), (II), (III) treated (IV) groups. Left was induced by partial left renal vein ligation. Reproductive hormones, epididymal sperm functional parameters, testicular 3/17 β-hydroxysteroid dehydrogenases,...
Abstract The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle adipose tissue the liver to integrate energy homeostasis under diet-induced obesity. We aimed explore putative role irisin in protection against postmenopausal rat model by modulating expenditure (EE). Bilateral ovariectomy (OVX) was performed. After 3 weeks...
Overweight and obesity are recognized as major drivers of cancers including breast cancer. Several cytokines, interleukin-6 (IL-6), IL-10 lipocalin 2 (LCN2), well dysregulated cell cycle proteins implicated in carcinogenesis. The nuclear, casein kinase cyclin-dependent substrate-1 (NUCKS-1), is a nuclear DNA-binding protein that has been several human cancers, cancer.The present study was conducted to evaluate NUCKS-1 mRNA expression tissue from obese patients with without cancer lean...
This study aimed to evaluate the potential mitigating effect of fisetin on monosodium glutamate (MSG)-induced testicular toxicity and investigate possible involvement silent mating type information regulation 2 homolog 1 (SIRT1) in this effect.Forty male rats were divided into normal control, fisetin-treated, MSG-treated, + MSG-treated groups. Testosterone, GnRH, FSH, LH measured plasma, as well SIRT1 phosphorylated AMP-activated protein kinase (pAMPK) levels tissues using ELISA. Hydrogen...
Lactoferrin (LF) was previously suggested to have a protective effect against liver fibrosis by preventing hepatic stellate cells (HSCs) activation. The of LF on heat shock protein 47 (HSP47) has not yet been studied so this study designed investigate HSP47 as potential target for management and comparing it with silymarin (SM) in thioacetamide (TAA)-induced model. Rats were divided into four groups; normal control, TAA (TAA-treated), (LF + TAA-treated), SM (SM TAA-treated). After 6 weeks,...
Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In present study, protective effect curcumin atrazin-intoxicated rats evaluated. Toxicity was induced by oral administration atrazine (400 mg/kg/day) 3 weeks. at dose 400 mg/kg/day given simultaneously route. Redox status, mitochondrial function, 8-hydroxydeoxyguanosine (8-OHdG) level...