A5033502699- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Apelin-related biomedical research
- Angiogenesis and VEGF in Cancer
- T-cell and Retrovirus Studies
- Natural Compounds in Disease Treatment
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Parasitic Diseases Research and Treatment
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Adipose Tissue and Metabolism
- Blood groups and transfusion
- RNA modifications and cancer
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
Tanta University
2018-2024
Institute of Clinical Research
2020
Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung architecture and function, resulting in severe respiratory failure death. It has no definite treatment. Empagliflozin (EMPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, protective potential PF. However, the mechanisms underlying these effects require further elucidation. Therefore, this study aimed to evaluate ameliorative effect of EMPA against bleomycin (BLM)-induced PF mechanisms. Twenty-four...
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a life-threatening clinical issue with limited preventive approaches, posing substantial challenge to cancer survivors. The anthraquinone diacerein (DCN) exhibits significant anti-inflammatory, anti-proliferative, and antioxidant actions. Its beneficial effects on DIC have yet be clarified. Therefore, this study investigated DCN’s cardioprotective potency its conceivable molecular targets against DIC. Twenty-eight Wister rats were assigned...
Abstract Objectives This study aimed to evaluate the urinary level of soluble CD163 (sCD163) in patients with type 2 diabetes as a potential early indicator diabetic nephropathy (DN). Methods cross-sectional included 60 and 20 healthy individuals. Patients were divided into three groups according their albumin/creatinine ratio: normoalbuminuric, microalbuminuric, macroalbuminuric groups. Urinary levels sCD163 (usCD163) measured using ELISA. Results The mean showed significantly increasing...
Octamer-binding transcription factor 4 (Oct4) is a that has an important role in stem cell differentiation and self-renewal. Oct4 also been implicated tumorigenicity of different cancers. This study aimed to analyze expression gastric carcinoma (GC) evaluate the relation between clinicopathologic parameters, tumor proliferation, angiogenesis addition patient survival.Oct4 mRNA was detected by quantitative reverse PCR (qRT-PCR) 45 GC specimens adjacent non-cancerous tissues. We found...
This study aimed to assess the diagnostic value of two serum angiogenetic markers neuropilin-1 (NRP-1) and angiopoietin-2 (ANG-2) in patients with hepatocellular carcinoma (HCC) their relation tumor characteristics. 149 subjects were recruited divided into 50 recently diagnosed HCC, 49 cirrhosis on top hepatitis C virus infection, healthy subjects. Serum NRP-1 ANG-2 estimated by ELISA. Alpha-fetoprotein (AFP) levels measured using fluorescence immunoassay. significantly higher HCC...
Ferroptosis is associated with oxidative stress (OS) and caused by iron-dependent lipid-peroxidative damage, but its role in PE unclear. The aim of this study to determine whether pannexin 1 (Panx1) toll-like receptor 4 (TLR4) are key regulators ferroptosis PE.The included 65 patients 25 healthy pregnant women. In normal placental tissues, OS markers, including Fe2+, malondialdehyde (MDA), reduced glutathione (GSH) levels, heme oxygenase-1 (HO-1) peroxidase (Gpx4) activity, were estimated....
This study aimed to investigate the prognostic role of circulating miR-146a in prediction early response imatinib treatment patients with chronic myeloid leukemia (CML). Sixty CML and 20 healthy controls were recruited this study. BCR-ABL was assessed by quantitative rt-PCR at days 0 90 therapy. Circulating levels 0, 14 therapy for once controls. At day treatment, achieved 48 (80.0%). Responders had significantly lower baseline Sokal score when compared non-responders. They also expression...
To assess the circulating micro-RNA-150 (miR-150) expression in patients with chronic myeloid leukemia (CML) relation to imatinib response.Sixty CML and 20 age- sex-matched control subjects were enrolled. Circulating miR-150 levels assessed by quantitative real-time polymerase chain reaction on days 0, 14, 90 of therapy for once subjects.The baseline was significantly lower than subsequent elevation at 14 after start treatment. Early treatment response (ETR) main study outcome. The had a...
Objectives: This study aims to investigate hemostatic changes in patients with coronavirus disease (COVID-19) and their relationship severity survival. Methods: included 284 COVID-19 who attended the Security Forces Hospital, Makkah, Saudi Arabia between October 2020 March 2021, retrospectively reviewed demographic, radiological, laboratory findings. The coagulation profile was assayed at time of diagnosis for platelet counts using an automated hematology analyzer; Sysmex XN2000 while...
Background and Objectives: Essential hypertension is a complex progressive cardiovascular disorder. Renin–angiotensin aldosterone system (RAAS) plays major role in blood pressure regulation. Aldosterone, synthesized the adrenal cortex by synthase encoded CYP11B2 gene. This case-control study was aiming to investigate relationship between gene (CYP11B2) biallelic polymorphism promoter at position −344 (−344C/T) with essential left ventricular hypertrophy Egyptian population.Methods: conducted...
Abstract Growing evidence supports the role of gut-kidney axis and persistent mitochondrial dysfunction in pathogenesis diabetic nephropathy (DN). Ulinastatin (UTI) has a potent anti-inflammatory effect, protecting kidney gut barrier sepsis, but its effect on DN yet to be investigated. This study aimed assess potential mitigating UTI investigate possible involvement homeostasis this effect. Forty male Wistar rats were divided equally into four groups: normal; UTI-treated control; untreated...
Growing evidence supports the role of gut microbiota in chronic inflammation, insulin resistance (IR) and sex hormone production polycystic ovary syndrome (PCOS). Adropin plays a pivotal regulation glucose lipid metabolism is negatively correlated with IR, which affects intestinal hormones. However, effect adropin administration PCOS has yet to be investigated. The present study aimed assess effects on letrozole (LTZ)-induced rats potential underlying mechanisms. experimental groups were...
Varicocele is a leading cause of male infertility. Melatonin highly pleiotropic neurohormone. We aimed to characterize the melatonin epigenetic potential in varicocele and involved molecular mechanisms.Fifty-two albino rats were randomly divided into four groups (13 each): control (I), (II), (III) treated (IV) groups. Left was induced by partial left renal vein ligation. Reproductive hormones, epididymal sperm functional parameters, testicular 3/17 β-hydroxysteroid dehydrogenases,...
<br><b>Background</b> The diagnosis of chronic myeloid leukemia (CML) is complex based mainly on the presence Philadelphia chromosome with morphological characteristics and leukocyte alkaline phosphatase (LAP) score. However, it can be confused should differentiated from different disorders including specifically leukemoid reaction (LR). HOX transcript antisense RNA (HOTAIR) expression may a useful biomarker for detection cancer.<br><b>Objective</b> This study was aimed to explore accuracy...
The objective of our study was to assess the effect human umbilical cord blood (HUCB) mesenchymal stem cells (MSCs) transplantation on schistosomal hepatic fibrosis in mice. animals were divided into three groups. Group I is a control group, where mice infected with Schistosoma mansoni cercariae and remained untreated. other two groups treated either praziquantel (Group II) or HUCB-MSCs III). Liver function tests, as well histopathological evaluation liver using hematoxylin eosin Masson's...
This study aimed to evaluate the potential mitigating effect of fisetin on monosodium glutamate (MSG)-induced testicular toxicity and investigate possible involvement silent mating type information regulation 2 homolog 1 (SIRT1) in this effect.Forty male rats were divided into normal control, fisetin-treated, MSG-treated, + MSG-treated groups. Testosterone, GnRH, FSH, LH measured plasma, as well SIRT1 phosphorylated AMP-activated protein kinase (pAMPK) levels tissues using ELISA. Hydrogen...