A5077637158- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Brucella: diagnosis, epidemiology, treatment
- Childhood Cancer Survivors' Quality of Life
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Cytomegalovirus and herpesvirus research
- Atherosclerosis and Cardiovascular Diseases
- Burkholderia infections and melioidosis
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Blood groups and transfusion
- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Kruppel-like factors research
- Folate and B Vitamins Research
- Hepatitis C virus research
- Diabetes Management and Research
- Mesenchymal stem cell research
Cairo University
2011-2025
Security Forces Hospital
2023-2024
Children Cancer Hospital
2019
Methicillin-resistant
Objectives: This study aims to investigate hemostatic changes in patients with coronavirus disease (COVID-19) and their relationship severity survival. Methods: included 284 COVID-19 who attended the Security Forces Hospital, Makkah, Saudi Arabia between October 2020 March 2021, retrospectively reviewed demographic, radiological, laboratory findings. The coagulation profile was assayed at time of diagnosis for platelet counts using an automated hematology analyzer; Sysmex XN2000 while...
N-Acetyltransferases (NAT) have been known to modify the risk a variety of solid tumors. However, role NAT2 polymorphism in susceptibility childhood acute lymphoblastic leukemia (ALL) is still not well known. We performed case-control study determine if common polymorphisms play altering pediatric ALL. DNA 92 ALL patients and 312 healthy controls was analyzed for using PCR-RFLP method. The wild-type NAT2*4 encountered 8.6 % versus 11.8 (P = 0.23). rapid acetylators NAT2*12 803A>G, AG, GG,...
The P53 tumor suppressor gene plays a pivotal role in maintaining cellular homeostasis by preventing the propagation of genome mutations. its transcriptionally active form is capable activating distinct target genes that contribute to either apoptosis or growth arrest, like P21. However, MDM2 major negative regulator P53. Single nucleotide polymorphisms (SNP) codon Arg72Pro results impairment activity gene. A similar effect caused SNP 31 In contrast, position 309 increased expression due...
Type 1 diabetes is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors thought to provide fundamental element for disease. Apart from Major Histocompatibility locus which main contributor risk susceptibility, more than 40 loci are recognized. One among these CTLA-4, however data literature controversial. The aim our study was investigate role CTLA4 49 A/G as a factor development type in cohort Egyptian families. This case...
Methods. We report the case of a 73-year-old Saudi female who presented with severe thrombocytopenia and mild autoimmune hemolytic anemia associated brucellosis. The coexistence published cases two hematological disorders brucellosis is rare. Results. Despite initial treatment eltrombopag intravenous immunoglobulin (IVIG), our patient’s platelets count remained low significantly improved after initiation in form rifampicin doxycycline. Discussion. conclude by reviewing that many parts...
Testing of blood donors for markers transfusion-transmitted infections (TTIs) such as HBV, HCV, HIV, HTLV, syphilis, and malaria is mandatory in Saudi Arabia. This study determined the prevalence all tested TTIs among western region Arabia.This retrospective included 5,473 who attended donation center at Security Force Hospital (SFH) located Arabia from January 1, 2015 to December 31, 2018. The was classified per year, gender, age, type (first-time vs. returned donors), category (replacement...
Abstract Background Type1 diabetes mellitus (T1DM) has a multi-factorial pathogenesis; the interplay between genetic susceptibility and environmental factors is thought to provide fundamental element for disease. Apart from HLA, more than 50 variants are associated with T1DM. INS -23/Hph1 A>T (rs689) one of effective loci inconsistent reports in literature. Accordingly, this study was designed define frequencies polymorphism its association T1DM Egyptian diabetic children their...
Background DNA-methyltransferase 3 A (DNMT3A) plays an important role in DNA methylation. Its mutation is the commonest mutated epigenetic regulator acute myeloid leukemia (AML). However, relation between DNMT3 polymorphism and AML risk Egyptian patients still unknown. Objectives To detect frequency of DNMT3A-448A>G (rs 1550117) single nucleotide a cohort adult with normal controls matched by age, sex, ethnicity to assess its effect on susceptibility AML. Patients methods PCR-restriction...