A5019863392- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Ocular Diseases and Behçet’s Syndrome
- Acute Myeloid Leukemia Research
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Glutathione Transferases and Polymorphisms
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Liver physiology and pathology
- Otitis Media and Relapsing Polychondritis
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Vasculitis and related conditions
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Blood groups and transfusion
- Blood disorders and treatments
Cairo University
2009-2024
Background: Because of the high prevalence hepatocellular carcinoma (HCC) in Egypt, new markers with better diagnostic performance than alpha-feto protein (AFP) are needed to help early diagnosis. The aim this work was compare clinical utility both serum and mRNA glypican3 (GPC3) as probable for HCC among Egyptian patients. Materials Methods: A total 60 subjects, including 40 HCC, 10 cirrhosis normal controls were analyzed GPC3 (sGPC3) by ELISA. GPC-3 from circulating peripheral blood...
Hepatocellular carcinoma (HCC) is usually asymptomatic in the early stage and does not show elevated alpha-feto protein (AFP). AFP shows 60-80% sensitivity diagnosing HCC. Glypican3 (GPC-3) an oncofetal that only detected HCC cells but benign liver tissues, while Carcinoembryonic antigen (CEA) expressed various neoplasms including Although, it specific for Prothrombin induced by vitamin K absence-II (PIVKA-II) abnormal prothrombin increased serum of patients. It has higher specificity...
The utility of routine chimerism analysis as a prognostic indicator subsequent outcomes after allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning regimens remains controversial. To address this controversy, test results at 2 to 6 months HCT were evaluated for association risk chronic graft-versus-host disease (GVHD), nonrelapse mortality (NRM), relapse, and overall mortality. Only 70 1304 patients (5%) had < 95% donor-derived cells in the marrow. Low donor...
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The interindividual genetic variations in drug metabolizing enzymes and DNA repair genes influence efficacy toxicity of numerous chemotherapeutic drugs affecting treatment outcome.The aim study was to investigate impact CYP1, GSTP1 (XRCC1) polymorphisms on response chemotherapy ALL.Ninety seven ALL pediatric patients were genotyped for CYP1A1, ILe105Val XRCC1 Arg194Tryp single nucleotide (SNPs) using PCR-RFLP.No...
BackgroundWilms' tumor (WT1) gene overexpression has been reported in the majority of acute myeloid leukemia (AML) patients at diagnosis and evaluated as prognostic minimal residual disease (MRD) marker.Patients methodsWT1 was 68 adult AML end induction using quantitative real-time polymerase chain reaction (PCR).ResultsNo significant associations were encountered between WT1 other factors. Complete remission (CR) achieved 74% with overexpresssion compared to 80% normal levels (P = 0.5). No...
Type 1 diabetes is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors thought to provide fundamental element for disease. Apart from Major Histocompatibility locus which main contributor risk susceptibility, more than 40 loci are recognized. One among these CTLA-4, however data literature controversial. The aim our study was investigate role CTLA4 49 A/G as a factor development type in cohort Egyptian families. This case...
Behçet disease is a multi-system associated with human leukocyte antigen (HLA) class I polymorphism. High-resolution next-generation sequencing (NGS) haplotype analysis has not been performed previously for this disease. Sixty Egyptian patients diagnosed according to the International Study Group (ISG) criteria and 160 healthy geographic ethnic-matched controls were genotyped HLA loci (HLA-A, B, C). For II (DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1), 40 control samples genotyped. genotyping was...
Behçet's disease is an autoimmune with diverse clinical manifestations vasculitis being the hallmark of disease. The aim this work to study genetic association between human leukocyte antigen (HLA) class-I molecules Egyptians and susceptibility patterns.Fifty-seven patients diagnosed according 1990 International Study Group (ISG) criteria for coming from Egyptian origin up third grandfather were included in study. Healthy controls taken HLA Class-I case control studies population yielding a...
<h3>Background</h3> Behçet9s syndrome is a multisystem autoimmune that has male predominance. Its manifestations usually start in the young adulthood with target organ damage affecting mainly skin, eyes, Brain and blood vessels <sup>(1)</sup> <h3>Objectives</h3> The aim of study was to investigate HLA class I genotyping cohort Egyptian patients comparing them healthy population (control group) estimate possible association between susceptibility as well presentations. <h3>Methods</h3>...
Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy. Protein phosphatase 2A (PP2A) major serine/threonine and tumor suppressor that negatively regulates numerous signal transduction pathways. Cancerous inhibitor of PP2A (CIP2A) an endogenous PP2A. CIP2A overexpression was shown to be recurrent event in cytogenetic normal AML patients. The aim the study evaluate prognostic significance patients with AML.Research design methods included 174 newly diagnosed...