A5051574040- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Glycosylation and Glycoproteins Research
- Machine Learning in Bioinformatics
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Delphi Technique in Research
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
University of Colorado Anschutz Medical Campus
2022-2024
University of Colorado Denver
2023
Universidade Federal do Paraná
2017-2021
Even though immunoglobulins are critical for immune responses and human survival, the diversity of immunoglobulin heavy chain gene (IGH) is poorly known mostly characterized by only serological methods. Moreover, this genomic region not well-covered in databases genome-wide association studies due to particularities that impose technical difficulties its analysis. Therefore, IGH has never been systematically sequenced across populations. Here, we deliver an unprecedented comprehensive...
Abstract Background Studies have identified individual blood biomarkers associated with chronic obstructive pulmonary disease (COPD) and related phenotypes. However, complex diseases such as COPD typically involve changes in multiple molecules interconnections that may not be captured when considering single molecular features. Methods Leveraging proteomic data from 3,173 COPDGene Non-Hispanic White (NHW) African American (AA) participants, we applied sparse canonical correlation network...
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells. KIR genes are encoded by a rapidly evolving gene family on chromosome 19 present an unusual variation presence absence high allelic diversity. Although many studies have associated polymorphism with susceptibility several diseases over last decades, high-resolution allele-level haplotypes only recently started be...
Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction KIR and HLA implicated in viral infections, autoimmunity, reproduction there growing evidence the coevolution these two independently segregating gene families. By leveraging HLA-C data from 1000 Genomes consortium we observed that KIR2DL1 variant rs2304224 * T associated with lower expression...
Studies have identified individual blood biomarkers associated with chronic obstructive pulmonary disease (COPD) and related phenotypes. However, complex diseases such as COPD typically involve changes in multiple molecules interconnections that may not be captured when considering single molecular features. Leveraging proteomic data from 3,173 COPDGene Non-Hispanic White (NHW) African American (AA) participants, we applied sparse canonical correlation network analysis (SmCCNet) to 4,776...
Genetically determined variation of killer cell immunoglobulin like receptors (KIR) and their HLA class I ligands affects multiple aspects human health. Their extreme diversity is generated through complex interplay natural selection for pathogen resistance reproductive health, combined with demographic structure dispersal. Despite significant importance to health conditions differential effect across populations, the nature extent immunogenetic under-studied many geographic regions. Here,...