A5027125676- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Neurological Complications and Syndromes
- Renal and related cancers
- Pharmacological Effects and Toxicity Studies
- Antifungal resistance and susceptibility
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Innovations in Medical Education
- Testicular diseases and treatments
- Glioma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Advances in Oncology and Radiotherapy
- Vascular Tumors and Angiosarcomas
- Neurofibromatosis and Schwannoma Cases
- Bacterial Identification and Susceptibility Testing
- Pancreatic and Hepatic Oncology Research
Cairo University
2016-2025
Children Cancer Hospital
2015-2024
Cancer Institute (WIA)
2023
Pediatric Oncology Group
2019
National Heart Institute
2018
The present paper is concerned with the study and publication of an unpublished offering basin belonging to individual named Mr-sw-anx, who lived during fifth Dynasty. It was found in his mastaba at Giza, excavated by S. Hassan 1929-1930, currently preserved Egyptian Museum Faculty Archaeology Cairo University under number (519/1234). offer good condition. made white limestone, rectangular shape two semi- equal depressions that gradually incline from top bottom. contains for liquid...
Carbapenem-resistant Enterobacteriaceae (CRE) is an important emerging threat among pediatric cancer patients, with a high mortality rate. This retrospective study included all patients bloodstream infections (BSIs) at children's hospital in Egypt (2013-2017). Two hundred and fifty-four CRE BSI were identified; 74% had hematological malignancies, 26% solid tumors. Acute myeloid leukemia was the most common malignancy (50%). The main clinical features for acquiring CRE-BSI previous...
Background Anaplastic large cell lymphoma (ALCL) constitutes 10-15% of childhood non-Hodgkin lymphoma. EFS is 70% and currently 80% with the additional targeted agents such as CD30 directed conjugated monoclonal antibody brentuximab or ALK inhibitors crizotinib. Expression CD3, a T-cell marker, can be lost diminished in some ALCL cases. The literature conflicting on whether CD3 expression affects prognosis, it has been analyzed mostly relapse setting. purpose this study was to determine...
Children with acute leukemia may experience high treatment-related mortality, which often occurs early in the induction phase. The aim of study was to assess incidence and risk factors related increased mortality during therapy pediatric patients leukemia. This is a retrospective that included who presented National Cancer Institute, Cairo University, between January 2011 December 2013. 370 patients, 253 lymphoblastic leukemia, 100 myeloid 17 mixed phenotype total death rates were 40.5%...
Mucormycosis represents a real challenge in immunocompromised patients. This study aimed to describe the clinical characteristics, treatment outcome and infection-related mortality our patients at Children's Cancer Hospital 57357, Cairo, Egypt. is retrospective during period 2007-2017. Data analysis included demographic data, risk factors, diagnostic workup, outcome. During period, 45 developed proven mucormycosis according EORTC/MSG criteria (2008). Ninety percentof cases were of...
The outcome for advanced neuroblastoma has improved with combined modality therapy: induction chemotherapy, surgery, and consolidation high-dose chemotherapy/autologous HSCT, followed by local radiation, cisretinoic acid, recently antibody therapy. In the United States, most common conditioning regimen is CEM, while in Europe/Middle East, Bu/Mel been widely used; it remains unclear which best outcome. Assess renal, hepatic, infectious toxicity through Day+100 2 different regimens....
Abstract Bloodstream infections (BSI) are a frequently observed complication after hematopoietic stem cell transplant (HSCT). Retrospective analysis of clinical and microbiological data during the first 100 days from 302 consecutive pediatric patients who underwent HSCT for malignant disease at our institute between January 2013 June 2017. A total 164 autologous 138 allogeneic HSCT. The overall incidence BSI was 37% with 92% infectious episodes occurring pre‐engraftment phase. Gram‐positive...
Abstract Childhood cancer is a priority in Egypt due to large numbers of children with cancer, suboptimal care and insufficient resources. It difficult evaluate progress survival because paucity data National Cancer Registry. In this study, we studied rates trends the largest available cohort (n = 15 779, aged 0‐18 years) from between 2007 2017, treated at Children's Hospital Egypt‐(CCHE), representing 40% 50% all childhood cancers across Egypt. We estimated 5‐year overall (OS) for 14 808...
Abstract Background Using fluoroquinolone prophylaxis in pediatric neutropenic patients is a controversial issue due to the concern about emergence of resistant strains addition lack studies. This study was performed assess effectiveness levofloxacin during autologous stem cell transplantation. Methods an observational who underwent transplantation, comparing received historical controls. Results A total 96 were included (46 control group and 50 levofloxacin). The median duration till onset...
To determine the prognostic value of quantitative fluorine-18-fluorodeoxyglucose (F-FDG) standardized uptake (SUV) in patients with pediatric rhabdomyosarcoma (RMS).Consecutive 98 (50 males and 48 females) (age range: 4 months to 17.5 years, mean age: 5.8 ± 4.5) pathologically proven RMS who underwent PET/computed tomography for initial staging were retrospectively assessed whether primary SUVmax primary/liver ratio could predict event-free survival (EFS) overall (OS) 36 using receiver...
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The interindividual genetic variations in drug metabolizing enzymes and DNA repair genes influence efficacy toxicity of numerous chemotherapeutic drugs affecting treatment outcome.The aim study was to investigate impact CYP1, GSTP1 (XRCC1) polymorphisms on response chemotherapy ALL.Ninety seven ALL pediatric patients were genotyped for CYP1A1, ILe105Val XRCC1 Arg194Tryp single nucleotide (SNPs) using PCR-RFLP.No...
Hepatosplenic fungal infection (HSFI) is a severe invasive observed during neutrophil recovery in patients with acute leukaemia treated intensive chemotherapy. Retrospective analysis including all paediatric haematological malignancies HSC Children Cancer Hospital Egypt (2013-2018). Twenty-five developed HSFI (19 diagnosed as hepatosplenic candidiasis). Most of the cases (92%) occurred induction phase. Organs affected were follows: liver 18 patients, renal 13 spleen 12 skin four and retina...
Acute myeloid leukemia (AML) is characterized by blocked or aberrant differentiation of hematopoietic stem cells. The MECOM gene overexpression in progenitors induces block, resulting increased self-renewal and survival these transformed progenitors. However, its exact role AML remains unclear. We aimed to estimate the prevalence among pediatric patients, assess impact on clinical outcome.Real-time quantitative polymerase chain reaction Livak method (2ΔΔCt) were used determine relative...
Molecular testing plays a pivotal role in monitoring measurable residual disease (MRD) acute myeloid leukemia (AML), aiding the refinement of risk stratification and treatment guidance. Wilms tumor gene 1 (
The purpose of this study was to assess the clinical and radiological patterns outcome predictors posterior reversible encephalopathy syndrome (PRES) in pediatric cancer patients. A retrospective included patients who developed PRES during their treatment at Children's Cancer Hospital Egypt. total 50 PRES. Leukemia lymphoma were commonest diagnoses (64%). Regarding MRI findings, occipital affection most common (92%), followed by frontal temporal lobes involvement 32% 22% respectively...
According to the Fifth National Wilms Tumor Study (NWTS-5), tumor-specific loss of heterozygosity (LOH) for chromosomes 1p and 16q identifies a subset patients with tumor (WT) who despite having favorable histology (FH) have significantly increased risk relapse death. We aimed find out LOH frequencies in FH-WT as well its correlation survival outcome epidemiologic clinical characteristics. Data presenting Cancer Institute, Egypt, were retrospectively analyzed. Paraffin blocks tested using...
Children and adolescents with HL have excellent long-term survival exceeding 95% after combined modality treatment. However, about 20% will either relapse or PRF. Salvage HDCT followed by AHSCT is considered to be the preferential treatment.To describe outcome (OS EFS) prognostic factors in pediatric patients relapsed refractory (r/rHL) who underwent AHSCT.We retrospectively included 43 r/rHL from July 1, 2007, till December 31, 2016, at Children's Cancer Hospital of Egypt. MAC regimen given...