A5059827356- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Eosinophilic Disorders and Syndromes
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- Childhood Cancer Survivors' Quality of Life
- Genomics and Phylogenetic Studies
- Connective Tissue Growth Factor Research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Cardiac tumors and thrombi
- PI3K/AKT/mTOR signaling in cancer
- GDF15 and Related Biomarkers
- Lung Cancer Treatments and Mutations
Fred Hutch Cancer Center
2015-2025
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2008-2024
University of Washington
2003-2023
University of Washington Tacoma
2022
Cancer Research And Biostatistics
2010
SWOG Cancer Research Network
2010
Increasing the upper age limit for recipients of hematopoietic stem cell transplantation (HCT) naturally has also increased corresponding related donor population. Because aging is a risk factor malignancies, transferring preexisting malignant or premalignant hemopoietic clones in process HCT might be expected to increase as well. Anecdotal clinical cases malignancies derived from cells patients undergoing have been published since 1971. In this article, we report 12 new that fit 2 different...
We used next-generation sequencing (NGS) of the immunoglobulin genes to evaluate residual disease in 153 specimens from 32 patients with adult B cell acute lymphoblastic leukemia enrolled a single multicenter study. The results were compared multiparameter flow cytometry (MFC) data 66 (25 patients) analyzed by both methods. There was strong concordance (82%) between methods qualitative determination presence disease. However, 17% cases, detected but not MFC. In 54 bone marrow (BM) and...
Clofarabine and cytarabine target different steps in DNA synthesis replication, are synergistic vivo, have non-overlapping toxicities, making this combination a potentially promising treatment for acute lymphocytic leukaemia. Thirty-seven patients were treated. The median age was 41 years, 44% of either ≥2nd relapse or had refractory disease 59% poor risk cytogenetics. Six out 36 (17%) achieved complete remission with without count recovery; overall survival 3 months. Nucleoside transporter...
Despite immense interest in the proteome as a source of biomarkers cancer, mass spectrometry has yet to yield clinically useful protein biomarker for tumor classification. To explore potential particular class spectrometry-based quantitation approaches, label-free alignment liquid chromatography coupled tandem (LC-MS/MS) data sets, identification acute leukemias, we asked whether algorithm could distinguish known classes leukemias on basis their proteomes. This approach involves (1)...
Treatments for adults with newly-diagnosed acute lymphoblastic leukemia (ALL) may be prohibitively toxic and/or resource-intense. To address this, we performed a phase II study of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH). Imatinib or dasatinib was added Ph + disease; rituximab when CD20+. Fifty-three patients were evaluable: 28 disease, 25 Ph−. All had ≥1 high-risk clinical feature. Measurable residual disease-negativity by multiparameter...
Recurrent gene fusions are common drivers of disease pathophysiology in leukemias. Identifying these structural variants helps stratify by risk and assists with therapy choice. Precise molecular diagnosis low-and-middle-income countries (LMIC) is challenging given the complexity assays, trained technical support, availability reliable electricity. Current fusion detection methods require a long turnaround time (7–10 days) or advance knowledge genes involved fusions. Recent technology...
Abstract Background Long-read sequencing has great promise in enabling portable, rapid molecular-assisted cancer diagnoses. A key challenge democratizing long-read technology the biomedical and clinical community is lack of graphical bioinformatics software tools which can efficiently process raw nanopore reads, support output interactive visualizations for interpretations results. Another obstacle that high performance data analyses often leverage graphics processing units (GPU),...