Saad Alghamdi

ORCID: 0000-0003-4532-9128
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About
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Research Areas
  • Nanoparticles: synthesis and applications
  • Liver Disease Diagnosis and Treatment
  • Synthesis and biological activity
  • Liver Disease and Transplantation
  • Hepatitis C virus research
  • Computational Drug Discovery Methods
  • Organ Transplantation Techniques and Outcomes
  • Medicinal Plants and Neuroprotection
  • Graphene and Nanomaterials Applications
  • Hepatitis B Virus Studies
  • Antibiotic Resistance in Bacteria
  • Tuberculosis Research and Epidemiology
  • Nanoparticle-Based Drug Delivery
  • SARS-CoV-2 and COVID-19 Research
  • Essential Oils and Antimicrobial Activity
  • Cholinesterase and Neurodegenerative Diseases
  • Mosquito-borne diseases and control
  • Liver Diseases and Immunity
  • Synthesis and Characterization of Heterocyclic Compounds
  • Natural Antidiabetic Agents Studies
  • COVID-19 Clinical Research Studies
  • Advanced Nanomaterials in Catalysis
  • Ethnobotanical and Medicinal Plants Studies
  • Phytochemicals and Antioxidant Activities
  • Pharmacological Effects of Natural Compounds

Umm al-Qura University
2014-2025

King Faisal Specialist Hospital & Research Centre
2011-2025

King Saud bin Abdulaziz University for Health Sciences
2022-2024

National Guard Health Affairs
2024

King Abdulaziz Medical City
2024

Johns Hopkins University
2024

King Abdullah International Medical Research Center
2024

King Abdulaziz University
2022-2024

King Khalid University
2024

Marwadi University
2024

Abstract A simple, eco-friendly, and biomimetic approach using Thymus vulgaris ( T . ) leaf extract was developed for the formation of ZnO-Ag nanocomposites (NCs) without employing any stabilizer a chemical surfactant. used first time, in novel approach, green fabrication NCs as size based reducing agent via hydrothermal method single step. Presence phenols has served both capping agents that play critical role production NCs. The effect silver nitrate concentration studied. in-vitro...

10.1038/s41598-019-44309-w article EN cc-by Scientific Reports 2019-06-05

Magnesium oxide nanostructured particles (NP) were prepared using a simple solution combustion technique different leaf extracts such as Mangifera indica (Mango - Ma), Azadirachta (Neem-Ne), and Carica papaya (Papaya-Pa) surfactants. The highly crystalline phase of MgO nanostructures was confirmed by PXRD FTIR studies for 2 h 500°C calcined samples. To analyze the characteristics obtained material-MaNP, NeNP, PaNP dosimetry applications, thermoluminescence (TL) carried out Co-60 gamma rays...

10.3389/fchem.2023.1143614 article EN cc-by Frontiers in Chemistry 2023-03-23

Aeromonas veronii is associated with substantial economic losses in the fish industry and food-borne illness humans. This study aimed to determine prevalence, antibiogram profiles, sequence analysis, virulence antimicrobial resistance genes, pathogenicity of A. recovered from Mugil seheli. A total 80 were randomly gathered various private farms Suez Province, Egypt. Subsequently, samples subjected clinical, post-mortem, bacteriological examinations. The retrieved isolates tested for profile,...

10.3390/pathogens11111262 article EN cc-by Pathogens 2022-10-29

Biofilms not only protect bacteria and Candida species from antibiotics, but they also promote the emergence of drug-resistant strains, making eradication more challenging. As a result, novel antimicrobial agents to counteract biofilm formation are desperately needed. In this study, Terminalia catappa leaf extract (TCE) was used optimize TCE-capped silver nanoparticles (TCE-AgNPs) via one-pot single-step method. Varied concentrations TCE have yielded different sized AgNPs. The...

10.3390/antibiotics10060725 article EN cc-by Antibiotics 2021-06-16

The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) and papain-like (PLpro) prevents viral multiplications; these enzymes have been recognized as one the most favorable targets for drug discovery against SARS-CoV-2. In present study, we screened 225 phytocompounds in 28 different Indian spices to identify compounds potential inhibitors SARS-CoV-2 Mpro PLpro. Molecular docking, molecular dynamics simulation, mechanics Poisson-Boltzmann surface...

10.1016/j.sjbs.2022.02.028 article EN cc-by-nc-nd Saudi Journal of Biological Sciences 2022-02-25

Bacillus cereus is a common food poisoning pathogen in humans. This study aimed to investigate the prevalence, molecular typing, antibiogram profile, pathogenicity, dissemination of virulence and antibiotic resistance genes associated with natural B. infection among Mugil seheli.Consequently, 120 M. seheli (40 healthy 80 diseased) were obtained from private fish farms Port-said Governorate, Egypt. Afterward, samples processed for clinical, post-mortem, bacteriological examinations. The...

10.2147/idr.s365254 article EN cc-by-nc Infection and Drug Resistance 2022-04-01

Pesticides are a class of xenobiotic compounds that recalcitrant and show persistence in the environment for longer period time. Research studies have linked their potential mutagenicity, teratogenicity, carcinogenicity. The accumulation pesticides water sources due to runoff from agricultural lands has posed serious threat biota ecosystem as well human population. Long-term exposure can cause neurological disorders, reproductive complications, cancer, immunological, pulmonary diseases. use...

10.1155/2022/2131583 article EN cc-by International Journal of Photoenergy 2022-06-08
Homie Razavi Marı́a Buti Norah A. Terrault Stefan Zeuzem Cihan Yurdaydìn and 86 more Junko Tanaka Alessio Aghemo Ulus Salih Akarca Nasser M. Al Masri Abduljaleel Alalwan Soo Aleman Abdullah S Alghamdi Saad Alghamdi Waleed K. Al‐Hamoudi Abdulrahman Aljumah Ibrahim Altraif Tarik Asselah Ziv Ben‐Ari Thomas Berg Mia J. Biondi Sarah Blach Wornei Silva Miranda Braga Carlos Eduardo Brandão‐Mello Maurizia Rossana Brunetto Joaquín Cabezas Hugo Cheinquer Pei‐Jer Chen Myeong-Eun Cheon Wan‐Long Chuang Carla S. Coffin Nicola Coppola Antonio Craxı̀ Javier Crespo Victor de Lédinghen Ann‐Sofi Duberg Ohad Etzion Maria Lúcia Gomes Ferraz Paulo Roberto Abrão Ferreira Xavier Forns Graham R. Foster Giovanni Battista Gaeta Ivane Gamkrelidze Javier García‐Samaniego Liliana Gheorghe Pierre M. Gholam Robert G. Gish Jeffrey S. Glenn Julian Hercun Yao‐Chun Hsu Ching‐Chih Hu Jee‐Fu Huang Naveed Z. Janjua Jidong Jia Martin Kåberg Kelly Kaita Habiba Kamal Jia‐Horng Kao Loreta A. Kondili Martin Lagging Pablo Lázaro Jeffrey V. Lazarus Mei‐Hsuan Lee Young‐Suk Lim Paul J. Marotta María Cristina Navas Marcelo Contardo Moscoso Naveira Mauricio Orrego Carla Osiowy Calvin Q. Pan Mário G. Pessôa Giovanni Raimondo Alnoor Ramji Devin Razavi‐Shearer Kathryn Razavi‐Shearer Cielo Ríos Manuel Rodríguez William Rosenberg Dominique Roulot Stephen Ryder Rifaat Safadi Faisal M. Sanai Teresa Santantonio Christoph Sarrazin Daniel Shouval Frank Tacke Tammo Lambert Tergast Juan Miguel Villalobos-Salcedo Alexis Voeller Hwai‐I Yang Ming‐Lung Yu Eli Zuckerman

Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, mortality compared to (HBV) monoinfection. Reliable estimates prevalence HDV disease burden are essential formulate strategies find coinfected individuals more effectively efficiently. The global HBV infections was estimated be 262,240,000 in 2021. Only 1,994,000 were newly diagnosed 2021, than half new diagnoses made China. Our initial...

10.1016/j.jhep.2023.02.041 article EN cc-by-nc-nd Journal of Hepatology 2023-04-07

Excessive use of antimicrobial medications including antibiotics has led to the emerging menace resistance, which, as per World Health Organization (WHO), is among top ten public health threats facing humanity, globally. This necessitates that innovative technologies be sought can aid in elimination pathogens and hamper spread infections. Zinc oxide (ZnO) multifunctionality owing its extraordinary physico-chemical properties functionality a range applications. In this research, ZnO...

10.1021/acsomega.3c03908 article EN cc-by-nc-nd ACS Omega 2023-07-24

Abstract Background Bacillus cereus is implicated in severe foodborne infection humans. This study intended to assess the occurrence, gro EL gene sequencing, biofilm production, and resistance profiles of emerged multidrug resistant (MDR) B. meat product samples. Moreover, this work highlights virulence toxigenic genes ( hbl ABCD complex, nhe ABC cyt K, ces , pc-plc ) antimicrobial bla 1, tet A, 2, B, erm A). Methods Consequently, 200 samples (sausage, minced meat, luncheon, beef liver; n =...

10.1186/s12866-024-03204-9 article EN cc-by BMC Microbiology 2024-02-07

Background and aim Artificial intelligence (AI)-powered chatbots, such as Chat Generative Pretrained Transformer (ChatGPT), have shown promising results in healthcare settings. These tools can help patients obtain real-time responses to queries, ensuring immediate access relevant information. The study aimed explore the potential use of ChatGPT-generated medical Arabic for with metabolic dysfunction–associated steatotic liver disease (MASLD). Methods An English patient questionnaire on MASLD...

10.1371/journal.pone.0317929 article EN cc-by PLoS ONE 2025-02-03

Blastocystis, a genetically diverse intestinal parasite with controversial pathogenic potential, has increasingly been incriminated for diarrheal illness in immunocompromised individuals including colorectal cancer (CRC) patients. The aim of the current study was to assess possible association between Blastocystis infection and CRC condition Makkah, Saudi Arabia (KSA).Stool samples were collected from 80 non-cancer (NC) 138 subjects 74 patients 64 other cancers outside gastrointestinal tract...

10.1186/s13027-017-0131-z article EN cc-by Infectious Agents and Cancer 2017-04-12

In the present study, antibiotic residues were detected in milk samples collected from dairy herds located Karnataka, India, by microbiological assay. Subsequently, antibiotics identified as azithromycin and tetracycline, high-performance liquid chromatography, further both cow found to be at high concentration (9708.7 5460 μg kg-1, respectively). We then investigated effects of temperature pH on stabilities tetracycline determine degradation rate constant k using first-order kinetic...

10.1371/journal.pone.0223475 article EN cc-by PLoS ONE 2019-10-10
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