A5014935339- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease and Transplantation
- Paraquat toxicity studies and treatments
- Contact Dermatitis and Allergies
- Gastrointestinal Tumor Research and Treatment
- Climate Change and Health Impacts
- HIV, Drug Use, Sexual Risk
- Hemoglobinopathies and Related Disorders
- Muscle and Compartmental Disorders
- Dermatology and Skin Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Hepatitis Viruses Studies and Epidemiology
- Acute Kidney Injury Research
- Air Quality and Health Impacts
- Complementary and Alternative Medicine Studies
- Liver Diseases and Immunity
- Trace Elements in Health
Keelung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2013-2023
Chang Gung Memorial Hospital
2008-2022
Tao Yuan General Hospital
2016
Memorial Hospital of South Bend
2012-2015
Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, mortality compared to (HBV) monoinfection. Reliable estimates prevalence HDV disease burden are essential formulate strategies find coinfected individuals more effectively efficiently. The global HBV infections was estimated be 262,240,000 in 2021. Only 1,994,000 were newly diagnosed 2021, than half new diagnoses made China. Our initial...
Paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality morbidity. The objective of this study was to identify predictors cases paraquat poisoning. Furthermore, we sought determine the association between these parameters.A total 187 patients were referred for management intentional ingestion January 2000 December 2010. Demographic, clinical, laboratory data recorded. Sequential organ assessment (SOFA) acute...
Paraquat intoxication is characterized by multi-organ failure, causing substantial mortality and morbidity. Many paraquat patients experience acute kidney injury (AKI), sometimes requiring hemodialysis. We observed 222 paraquat-intoxicated between 2000 2012, divided them into AKI (n = 103) non-AKI 119) groups. The rate was higher for than (70.1% vs. 40.0%, P < 0.001). Patients with had a longer time to hospital arrival (P 0.003), lower PaO2 0.006) alveolar-arterial O2 difference 0.001) 48 h...
IntroductionParaquat poisoning is characterized by acute lung injury, pulmonary fibrosis, respiratory failure, and multi-organ resulting in a high rate of mortality morbidity. The objectives this study were to identify predictors distress syndrome (ARDS) cases paraquat determine the association between these parameters. Materials MethodsIn total, 187 patients referred for management intentional ingestion 2000 2010. Demographic, clinical, laboratory data recorded. Sequential organ failure...
Summary Due to the introduction of newer, more efficacious treatment options, there is a pressing need for policy makers and public health officials develop or adapt national hepatitis C virus ( HCV ) control strategies changing epidemiological landscape. To do so, detailed, country‐specific data are needed characterize burden chronic infection. In this study 17 countries, literature review published unpublished on prevalence, viraemia, genotype, age gender distribution, liver transplants...
Summary Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar Taiwan) quantify characterize population as well forecast changes in infected corresponding disease burden from 2015...
Aortic pulse wave velocity (PWV) has been shown to be an independent predictor of cardiovascular mortality in patients with end-stage renal disease and the general population. Atmospheric particulate- matter (PM) concentrations their effects on system by affecting arterial stiffness central hemodynamic parameters had noted. The purpose this study was access correlation air pollution variables PWV undergoing hemodialysis (HD). This analyzed 127 HD treated at outpatient center. Brachial-ankle...
Summary The hepatitis C virus ( HCV ) epidemic was forecasted through 2030 for 17 countries in Africa, Asia, Europe, Latin America and the Middle East, interventions achieving Global Health Sector Strategy on viral targets—“ WHO Targets” (65% reduction ‐related deaths, 90% new infections of diagnosed by 2030) were considered. Scaling up treatment diagnosis rates over time would be required to achieve these targets all but one country, even with introduction high SVR therapies. scenarios...
Background/Aims: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality Studies on correlation between cardiovascular or UP limited. Methods: We analyze 866 hemodialysis (MHD) our centers. Clinical parameters 24-month infection-related recorded. Results: The associations all-cause, with clinical data including analyzed. Multivariate Cox regression demonstrated that a...
Abstract Background Circulating tumor cells (CTCs) are associated with breast cancer prognosis. Research is limited regarding the role of circulating stem-like (cCSCs) considering treatment response and survival among patients metastatic cancer. Accordingly, we performed this prospective study to clarify prognostic significance baseline cCSCs for in terms first-line chemotherapy. Methods Between April 2014 January 2016, prospectively enrolled 48 stage IV invasive ductal carcinoma who...
Summary Background Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis C virus ( HCV ) infection. Aim To evaluate pegylated interferon (peg IFN plus ribavirin RBV ‐infected patients. Methods Ninety‐one (age ≥65 years; elderly group) infection 91 gender‐ genotype‐matched middle‐aged 50–64 younger were assigned to receive weekly peg injection weight‐based oral for 24 weeks. The on‐ off‐treatment virological responses evaluated...
CO2 has been reported to be absorbed from the bowel more rapidly than air, resulting in a discomfort reduction after colonoscopy. Its role deeply sedated patients is limited. This study was designed investigate efficacy and safety of insufflation during colonoscopy with propofol.A total 125 continuous were randomly assigned receive either (n = 63) or air 62) propofol-sedated Postcolonoscopy abdominal pain, distention, satisfaction assessed at 1, 3, 24 h procedure, proportions pain-free...
Patients with non-alcoholic fatty liver disease (NAFLD) share similar pathophysiologies to those of patients alcohol disease. Alcoholic metabolic enzyme-related genes (alcohol dehydrogenase 1B (ADH1B) and aldehyde 2 (ALDH2)) may be associated pathophysiology in NAFLD patients. In this study, the association between ADH1B/ALDH2 gene polymorphism serum factors, body statures, hepatic steatosis/fibrosis status was evaluated NAFLD. Using biochemistry data, abdominal ultrasonography, fibrosis...
CD4+Foxp3+ regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, was proposed to be cause chronicity hepatitis B virus (HBV) infection but controversies. We then investigated role mTregs in distinct phases chronic HBV infection, especially non-inflammatory versus inflammatory phases. It found not rTregs increased only phase correlated serum alanine aminotransferase...
Abstract Serum albumin had been noted to be a predictor of mortality in hemodialysis (HD) patients. Normalized protein catabolic rate (nPCR) less than 0.8 or greater 1.4 g/kg/d was also associated with mortality. There no previous study show the effectiveness combination serum and nPCR predict chronic HD Eight hundred sixty-six patients were divided into 4 groups according their levels. Biochemical, hematological parameters recorded. The associations between groups, variables mentioned above...
Patients with chronic hepatitis C virus (HCV) infection are at a greater risk of developing insulin resistance (IR). However, little is known about when sensitivity may improve during or after treatment for C. In this study, we examined the effect combination therapy pegylated interferon-α and ribavirin on IR in patients HCV infection. We also analyzed factors associated changes sensitivity. was estimated by homeostasis model assessment (HOMA-IR). HOMA-IR measured before therapy, (12 24...
The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one the complications dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter <2.5 mm (PM2.5), have significantly been associated elevation systemic inflammatory markers. There no previous research on possible associations between CTS and PM2.5.This study enrolled 866 MHD patients treated...
Background:The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation highly toxic and carcinogenic acetaldehyde.It can induce unpleasant "Asian flush syndrome" associate increased risk cancers.However, date, little is known about in relation the postoperative prognosis hepatocellular carcinoma (HCC).Methods: From 2002 2012, 419 HCC patients receiving surgical resection were enrolled for...
Abstract Background: Proteinuria in patients with diabetes mellitus (DM) is sometimes caused by glomerular diseases other than diabetic nephropathy. In type 2 DM (T2DM), specific predictors for non‐diabetic renal disease (NDRD) are needed addition to the traditional indicators biopsy. Methods: From 1 January 2000 31 March 2011, we retrospectively enrolled 54 T2DM proteinuria who had undergone biopsies into present study. Associations between NDRD and 20 potential biomarkers, including serum...
Introduction . A bone marrow biopsy is a useful procedure for the diagnosis and staging of various hematologic systemic diseases. The objective this study was to investigate whether findings studies can predict mortality in chronic hemodialysis patients. Methods Seventy-eight end-stage renal disease patients on maintenance underwent biopsies between 2000 2011, with most common indication being unexplained anemia followed by leukocytosis leukopenia. Results survivors had higher incidence...
The advantage of hemodiafiltration (HDF) is well known. One the disadvantages HDF loss serum albumin, but this issue still obscure. Some risk factors associated with mortality were age dependent. Studies on albumin/hypoalbuminemia and in different stratification limited. aim cross-sectional study was to assess role other clinical variables albumin values maintenance hemodialysis (MHD) patients groups. We recruited a total 1216 MHD. Patients divided into 4 groups by youth (<30 years old),...
Factors of metabolic syndrome such as obesity are well-known risk factors for gallstone disease (GSD). There different indicators obesity, including weight, body mass index, waist circumference, and waist-to-height ratio. The predictive ability GSD remains unclear.
Combination therapy with pegylated interferon (pegIFN)-α and ribavirin (RBV) for chronic hepatitis C virus (HCV) infection is associated reduction in hemoglobin (Hb) concentrations anemia. The aim of this study was to evaluate the magnitude frequency change Hb determine predictive risk factors decrease during therapy.We enrolled 308 patients HCV who were receiving weekly subcutaneous pegIFN injection combination body weight-based oral RBV 24 weeks. Clinical virological characteristics used...
Although uremic pruritus (UP) is a common and annoying symptom for end-stage renal disease patients on hemodialysis (HD) peritoneal dialysis, its pathogenesis poorly understood. However, systemic inflammation one of the possible UP, blood lead level (BLL) has been noted to be associated with nutritional status in long-term HD patients. There might an interaction or association, therefore, between BLL UP through inflammation. We analyzed cross-sectional data among 866 participants. All this...