A5079715763- Dialysis and Renal Disease Management
- Heavy Metal Exposure and Toxicity
- Paraquat toxicity studies and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Pesticide Exposure and Toxicity
- Poisoning and overdose treatments
- Central Venous Catheters and Hemodialysis
- Climate Change and Health Impacts
- Chronic Kidney Disease and Diabetes
- Trace Elements in Health
- Muscle and Compartmental Disorders
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Pesticide and Herbicide Environmental Studies
- Healthcare cost, quality, practices
- Acute Ischemic Stroke Management
- Pharmacological Effects and Toxicity Studies
- Erythropoietin and Anemia Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Myeloid Leukemia Research
- Parathyroid Disorders and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Biosensors and Analytical Detection
- Suicide and Self-Harm Studies
Chang Gung University
2016-2025
Chang Gung Memorial Hospital
2016-2025
Linkou Chang Gung Memorial Hospital
2015-2024
Memorial Hospital of South Bend
2009-2023
Mackay Memorial Hospital
2023
Taichung Veterans General Hospital
2023
China Medical University
2021-2023
Memorial
2022
Kidney Research UK
2019-2020
Chiayi Chang Gung Memorial Hospital
2020
Inflammatory markers such as interleukin (IL)-6 and tumour necrosis factor-alpha (TNF-α) are elevated in dialysis patients can predict cardiovascular events all-cause mortality. Endotoxin is an important source also another marker of inflammation with chronic kidney disease. The aim this study was to evaluate the impact oral probiotics on serum levels endotoxemia cytokines peritoneal (PD) patients. decline residual renal function, peritonitis episodes, were recorded. From July 2011 June...
<h3>Background:</h3> Studies into the association between hypertensive disorders during pregnancy and end-stage renal disease are limited. We investigated risk of after delivery among women with pregnancy. <h3>Methods:</h3> used insurance claims data from 1998 to 2009 identify 26 651 aged 19–40 years old who experienced pregnancy; these had no history hypertension, diabetes, kidney or lupus. also randomly selected 213 397 without as a comparison cohort; frequency was matched by age index...
Abstract Background Diabetic nephropathy (DN) has been recognized as the leading cause of end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, indicated to possess an insulin-like property in diabetes. In present study, we aimed investigate renoprotective effects RSV and delineate its underlying mechanism early-stage DN. Methods The protective on DN were evaluated streptozotocin (STZ)-induced diabetic rats. Results plasma glucose, creatinine, blood urea nitrogen significantly...
<h3>Importance</h3> Glucagon-like peptide-1 (GLP-1) receptor agonist use is associated with reduced mortality and improved cardiovascular outcomes in the general population diabetes. Dipeptidyl peptidase-4 (DPP-4) inhibitors are commonly used antidiabetic agents for patients advanced-stage chronic kidney disease (CKD). The association of these 2 drug classes among diabetes CKD or end-stage (ESKD) not well understood. <h3>Objective</h3> To assess whether GLP-1 agonists a ESKD better compared...
Surface-enhanced Raman spectroscopy (SERS)-based biosensors have attracted much attention for their label-free detection, ultrahigh sensitivity, and unique molecular fingerprinting. In this study, a wafer-scale, ultrasensitive, highly uniform, paper-based, portable SERS detection platform featuring abundant dense gold nanopearls with narrow gap distances, are prepared deposited directly onto ultralow-surface-energy fluorosilane-modified cellulose fibers through simple thermal evaporation by...
This paper introduces the concept of "Drawing-PADs" (Drawing paper-based microfluidic analytical devices) allowing to intuitively evaluate urinary albumin (Alb) index, a clinically important parameter used for early detection renal deficiencies related diabetes, among others. To enable regular monitoring Alb simple examination method suitable self-diagnosis is highly desirable. The Drawing-PADs rely on simultaneous naked eye and creatinine (Cre) single device according distance-based PAD...
Abstract Introduction This retrospective observational study examined the clinical features, degrees of toxic hepatitis, physiological markers and outcomes after intentional paraquat poisoning sought to determine what association, if any, might exist between these findings. Methods A total 187 patients were referred for management ingestion 2000 2010. Patients categorized into two groups according their hepatic complication, i.e. with ( N = 87) or without 100) hepatitis. Demographic,...
Background Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2−4 h after intoxication effectively reduces mortality, the effect early HP humans remains unknown. Methods We analyzed records all PQ-poisoned admitted 2 hospitals between 2000 and 2009. Patients were grouped according or late high-dose (oral cyclophosphamide [CP] intravenous dexamethasone [DX]) repeated pulse...
Objectives We aimed at determining peptic ulcer disease (PUD) incidence among chronic kidney (CKD) patients during 1998–2008, compared to without CKD, and examining associations between CKD PUD. Methods Data for 1998–2008 were extracted from the National Health Insurance Research Database in Taiwan. The annual PUD (cases per thousand persons year) was calculated separately with CKD. Characteristics of newly diagnosed (n = 16322) those a control group 32644). 2 groups matched age, sex, index...
Paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality morbidity. The objective of this study was to identify predictors cases paraquat poisoning. Furthermore, we sought determine the association between these parameters.A total 187 patients were referred for management intentional ingestion January 2000 December 2010. Demographic, clinical, laboratory data recorded. Sequential organ assessment (SOFA) acute...
Background Little is known on the effectiveness of influenza vaccine in ESRD patients. This study compared incidence hospitalization, morbidity, and mortality end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) between cohorts with without vaccination. Methods We used insurance claims data from 1998 to 2009 Taiwan determine these events within one year after vaccination (N = 831) non-vaccine 3187) cohorts. The cohort rate ratio hazard (HR) morbidities were measured. Results...
Paraquat intoxication is characterized by multi-organ failure, causing substantial mortality and morbidity. Many paraquat patients experience acute kidney injury (AKI), sometimes requiring hemodialysis. We observed 222 paraquat-intoxicated between 2000 2012, divided them into AKI (n = 103) non-AKI 119) groups. The rate was higher for than (70.1% vs. 40.0%, P < 0.001). Patients with had a longer time to hospital arrival (P 0.003), lower PaO2 0.006) alveolar-arterial O2 difference 0.001) 48 h...
Methanol poisoning is a serious public health issue in developing countries, but few data are available the literature on acute kidney injury (AKI) after methanol intoxication. This study examined clinical features, spectrum and outcomes of AKI patients with intoxication evaluated predictors mortality A total 50 were seen at Chang Gung Memorial Hospital between 2000 2013. Patients grouped according to status renal damage as (n = 33) or non-AKI 19). Demographic, clinical, laboratory, obtained...
Background: The negative impacts of particulate matter with an aerodynamic diameter 2.5 μm or less (PM ) are well known. Patients undergoing maintenance hemodialysis (HD) have significantly higher blood cadmium levels (BCLs) than healthy individuals. As elemental can be found in the PM particle fraction, we conducted this study to assess effect environmental exposure and other clinical variables on BCLs HD patients. Patient Methods: This cross-sectional included 754 hD patients who had...
Previous research suggest that repeated lead-chelation therapy decelerates progression of renal insufficiency in non-diabetic (non-DM) patients with high-normal body lead burden (BLB). Study findings are limited by relatively short-term follow-up and small sample size.A total 116 non-DM chronic kidney diseases (serum creatinine level 1.5-3.9 mg/dl), BLB (>60 microg <600 microg) no exposure history were randomly assigned to a chelation or control group this 4-year clinical trial. For 3...