A5049281923- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Esophageal and GI Pathology
- Liver physiology and pathology
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Gastrointestinal disorders and treatments
- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- Biliary and Gastrointestinal Fistulas
- Genomic variations and chromosomal abnormalities
- Pediatric Hepatobiliary Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Artificial Intelligence in Healthcare
- Actinomycetales infections and treatment
- Abdominal vascular conditions and treatments
- Obesity and Health Practices
King Faisal Specialist Hospital & Research Centre
2020-2025
Riyadh Armed Forces Hospital
2010-2019
King Fahad Hospital Jeddah
2011
Background and aim Artificial intelligence (AI)-powered chatbots, such as Chat Generative Pretrained Transformer (ChatGPT), have shown promising results in healthcare settings. These tools can help patients obtain real-time responses to queries, ensuring immediate access relevant information. The study aimed explore the potential use of ChatGPT-generated medical Arabic for with metabolic dysfunction–associated steatotic liver disease (MASLD). Methods An English patient questionnaire on MASLD...
Abstract Background The clinical utility of exome sequencing is now well documented. Rapid (RES) more resource-intensive than regular and typically employed in specialized settings wherein urgent molecular diagnosis thought to influence acute management. Studies on the RES have been largely limited outbred populations. Methods Here, we describe our experience with rapid a highly consanguineous population. Clinical included intensive care units, prenatal cases approaching legal cutoff for...
Hepatitis C virus (HCV) is a single stranded RNA virus. It affects millions of people worldwide and considered as leading cause liver diseases including cirrhosis hepatocellular carcinoma. A recent study reported that TLR4 gene polymorphisms are good prognostic predictors associated with protection from fibrosis among Caucasians. This aims to investigate the implication genetic on HCV infection in Saudi Arabian patients. Two SNPs gene, rs4986790 (A/G) rs4986791 (C/T), were genotyped 450...
// Ahmed A. Al-Qahtani 1, 2 , Mashael R. Al-Anazi 1 Nyla Nazir Rohit Ghai 3 Ayman Abdo 4, 8 Faisal M. Sanai 5, Waleed K. Al-Hamoudi Khalid Alswat Hamad I. Al-Ashgar 6 Mohammed Q. Khan Ali Albenmousa 7 Damian Dela Cruz Marie Fe F. Bohol and N. Al-Ahdal Department of Infection Immunity, Research Center, King Specialist Hospital & Riyadh, Saudi Arabia Microbiology Immunology, Alfaisal University School Medicine, Institute Hydrobiology, Aquatic Microbial Ecology, Biology Centre the Academy...
Introduction: The combination of sofosbuvir (SOF) with simeprevir (SMV) or daclatasvir (DCV) is very effective in treating hepatitis C virus (HCV) infection, particularly genotype (GT) 1. However, the data on GT4 are limited. We aimed to determine efficacy and safety SOF either SMV DCV GT4-infected patients. Patients Methods: In this real life, prospective, observational study, HCV (GT4) patients (n=96) were evaluated 2 groups basis 12-week treatment regimen they received. Group 1 (n=56)...
Viral mutations acquired during the course of chronic hepatitis B virus (HBV) infection are known to be associated with progression and severity HBV-related liver disease. This study HBV-infected Saudi Arabian patients aimed identify amino acid substitutions within precore/core (preC/C) region HBV, investigate their impact on disease towards hepatocellular carcinoma (HCC). Patients were categorized according disease, divided into following groups: inactive HBV carriers, active cirrhosis...
Autoimmune hepatitis (AIH) may present acutely, which can rapidly progress to fulminant type. This pattern has been described worldwide but is generally under-reported. We aim describe the clinical presentation and treatment outcomes of patients with acute onset AIH.A multicenter retrospective cohort study AIH. Clinical, biochemical, histological data were analyzed reported.Seventy included. The mean age was 33.8±1.5 years 58.6% female. Upon initial presentation, 94% had jaundice, 44%...
Hepatocellular carcinoma (HCC) is one of the leading causes death in Saudi male patients. Local clinical and demographic data this disease are scarce.We sought to describe characteristics outcomes patients from two tertiary care centers Arabia.Data were collected for all diagnosed have hepatocellular between June 2003 July 2008 who had been registered a special research database (the Observatory Liver Disease Registry (SOLID)). Data extracted SOLID clinical, biochemical, radiologic...
Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited.We analyzed of IL28B SNPs (hematological, biochemical, virological, and pathological factors) SVR HCV-G4 monoinfected cohort patients.One...
Recent studies have demonstrated that polymorphisms near the interleukin-28B (IL-28B) gene could predict response to Peg-IFN-a/RBV combination therapy in HCV-infected patients. The aim of study was correlate serum level IL28B patients with virus genotype/subgenotype and disease progression. detected variations at five single nucleotide (SNPs) region were genotyped analyzed. variation genetic found be strongly associated HCV infection when healthy control group compared all<mml:math...
Abstract Background Several trend analyses on liver transplantation (LT) indications have been published in the U.S. and other countries, but there are limited data LT indication trends Saudi Arabia (SA), especially since availability of direct-acting antivirals (DAAs) treatment for hepatitis C virus (HCV). This study aimed to analyze frequency among recipients SA over a 19-year period examine associations between etiologic-specific clinicodemographic characteristics. Methods retrospective...
Pulmonary complications after bariatric surgeries are rare but usually serious. They often occur early surgery the presentation might be delayed for several months. Gastropleural fistula is extremely and has been reported in a very small number of patients post sleeve gastrectomy gastric bypass. A 37-year-old lady presented with left sided pleural effusion empyema 2 years single anastomosis bypass surgery. She was found to have large gastropleural managed by surgical repair conversion...
Summary The aim of this study was to evaluate the association 10 SNP s in different micro RNA (mi s) with susceptibility hepatitis B virus ( HBV ) infection, clearance, persistence chronic and progression liver cirrhosis hepatocellular carcinoma HCC ). Patients were categorized into following groups: inactive carrier, active ‐cleared subject cirrhosis+ . Samples analysed for using either PCR ‐based genotyping or TaqMan assay. We found that rs1358379 associated persistent infection In...
Interleukin-37 (IL-37) has recently been recognized as a strong anti-inflammatory cytokine having anti-tumor activity against hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients. HCC is typical inflammation-related cancer, and genetic variations within the IL-37 gene may be associated with risk of HBV infection. Identification allelic patterns that genetically have high disease essential for development preventive diagnostics HBV-mediated liver pathogenesis. In this...
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common worldwide. We prospectively evaluated endothelial function by assessing flow-mediated dilatation (FMD) of brachial artery in patients with biopsy-proven NAFLD. This prospective study included 139 (50 healthy controls, 47 steatosis and 42 steatohepatitis), all whom were nondiabetic. Patients long-standing or uncontrolled hypertension, smokers, morbidly obese excluded. The medians (ranges) for vascular FMD steatohepatitis,...
Liver retransplant is considered the only hope for patients with irreversible graft failure after primary transplant. In most Western centers, retransplantis done mainly from deceased donors; so far, few published studies have reported on outcomes of liver living donors. this study, our aim was to analyze living-donor retransplant.Patients who underwent between February 2011 and 2019 were included in study. Preoperative, operative, postoperative data analyzed. Results 2 patient groups...
Variations at DEPDC5 gene have been recently reported as genetic markers associated with hepatocellular carcinoma (HCC) progression in chronic HCV-infected patients. This study was conducted to assess the association of variants advanced liver cirrhosis and HCC development among patients Saudi Arabian population. Six-hundred one were genotyped for polymorphisms (rs1012068 rs5998152), comparison 592 non-infected healthy control subjects. The allelic frequency genotype distribution both...
<h3>Objectives:</h3> To assess the outcomes of different types bariatric surgeries in a single newly established private obesity center. <h3>Methods:</h3> Retrospectively, we included patients who were entered registry for Obesity Unit, Riyadh National Hospital, Riyadh, Saudi Arabia between January 2013 and September 2014, completed one year follow up. Baseline characteristics, percent excess weight loss, safety data collected analyzed. <h3>Results:</h3> A total 79 included. Based on type...