A5066097397- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- T-cell and Retrovirus Studies
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Blood groups and transfusion
- Renal and related cancers
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Nanoparticles: synthesis and applications
- Genomic variations and chromosomal abnormalities
- SARS-CoV-2 detection and testing
- Medicinal Plants and Neuroprotection
- 3D Printing in Biomedical Research
King Abdulaziz University
2021-2025
Walter and Eliza Hall Institute of Medical Research
2014-2023
The University of Melbourne
2015-2023
KU Leuven
2019
VIB-KU Leuven Center for Cancer Biology
2019
RMIT Europe
2015
Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human that poorly understood at the molecular level. Here we report translocations targeting zinc finger E-box-binding transcription factor ZEB2 as recurrent genetic lesion in immature/ETP-ALL. Using conditional gain-of-function mouse model, demonstrate sustained Zeb2 expression initiates leukaemia. Moreover, Zeb2-driven exhibit some features immature/ETP-ALL gene signature, well an enhanced leukaemia-initiation potential...
Alzheimer's disease (AD), the most predominant cause of dementia, has evolved tremendously with an escalating frequency, mainly affecting elderly population. An effective means delaying, preventing, or treating AD is yet to be achieved. The failure rate dementia drug trials been relatively higher than in other disease-related clinical trials. Hence, multi-targeted therapeutic approaches are gaining attention pharmacological developments.As extension our earlier reports, we have performed...
Reduced Folate Carrier1 (RFC1) gene's metabolism is crucial for DNA synthesis, epigenetic mechanisms, and cellular methylation events. Nonetheless, RFC1 polymorphisms have drawn a lot of interest in current medical genetics studies. The objectives the study were to ascertain relationship between risk acute lymphoblastic leukemia Sudanese patients genetic variant (G 80A). Using Real-Time Polymerase Chain Reaction (RT-PCR) method, 150 Acute Lymphoblastic Leukemia (ALL) healthy control...
Abstract Herein, the synthesis of silver nanoparticles using extracts pistachio seed coat waste is investigated. The surface plasmon resonance peak at 443 nm was observed in by ultraviolet-visible spectroscopy (UV-Vis). To identify potential biomolecules involved bio-reduction ions, Fourier-transform infrared (FTIR) used. Scanning and transmission electron microscopy (SEM TEM) show irregular shapes with an average size ∼20 nm. active determined Brunauer, Emmett, Teller analysis 22 m 2 /g....
This study aimed to synthesise montelukast-loaded polymeric nanoparticles via the ionic gelation method using chitosan as a natural polymer and tripolyphosphate crosslinking agent. Tween 80, hyaluronic acid leucine were added modify physicochemical properties of nanoparticles, reduce nanoparticles’ uptake by alveolar macrophages improve powder aerosolisation, respectively. The ranged from 220 nm 383 with polydispersity index ≤0.50. zeta potential 11 mV 22 mV, drug association efficiency...
With the burgeoning worldwide aging population, incidence of Alzheimer's disease (AD) and its associated disorders is continuously rising. To appraise other relevant drug targets that could lead to potent enzyme targeting, 13 previously predicted ligands (shown favorable binding with AChE (acetylcholinesterase) GSK-3 (glycogen synthase kinase) were screened for targeting 3 different enzymes, namely butyrylcholinesterase (BChE), monoamine oxidase A (MAO-A), B (MAO-B) possibly meet unmet...
Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show oncogenic transcription factor Lmo2 causes maintenance transgenic mice by inhibiting early T cell differentiation. This results development of self-renewing preleukemic stem cells (pre-LSCs) and subsequent leukemogenesis, both which are profoundly inhibited restoration or expression antiapoptotic BCL2. Genomic analyses revealed presence...
Abstract Background Acute myeloid leukemia (AML) is a hematological malignancy that remains therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking bone marrow (BM) microenvironment are needed. This study aimed achieve an automated fabrication process three-dimensional (3D) AML model recapitulates 3D spatial structure BM applies drug screening investigational studies....
P2Y12 receptor is required for sustained activation of integrin αIIbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with αIIbβ3 plays critical roles in regulation growth stability vivo. The possible functional relationship between a molecular cluster platelets may affect formation. Hence our aim was to investigate the physical requirements this association platelets. Our investigations reveal specific constitutive human shown...
Testing of blood donors for markers transfusion-transmitted infections (TTIs) such as HBV, HCV, HIV, HTLV, syphilis, and malaria is mandatory in Saudi Arabia. This study determined the prevalence all tested TTIs among western region Arabia.This retrospective included 5,473 who attended donation center at Security Force Hospital (SFH) located Arabia from January 1, 2015 to December 31, 2018. The was classified per year, gender, age, type (first-time vs. returned donors), category (replacement...
Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, epigenetic processes. It encoded by the MTRR gene, which garnered a lot of attention current medical genetics research. This study was conducted to association between (A66G) polymorphism risk developing acute lymphoblastic leukemia among Sudanese patients. Materials Methods. case-control 150 patients with (ALL) healthy participants as control group were enrolled....
The use of tyrosine kinase inhibitors (TKIs) and other targeted therapeutics plays a pivotal role in treatment management for individuals diagnosed with chronic myeloid leukemia (CML). However, some patients may experience fewer favorable outcomes resistance. Our work aims to whole transcriptome sequencing evaluate the variations gene expression patterns among CML based on their response TKI therapy.
α-thalassemia (α-thal) is a genetic disorder characterized by decreased synthesis of α-globin chains. A deletion mutation most often causes it in one or more No comprehensive characterization studies have been conducted on α-thal patients the Saudi population. Therefore, this research aims to identify spectrum mutations responsible for our region. Individuals with microcytic, hypochromic red blood cells and normal hemoglobin (Hb) A2 were enrolled. Sixty samples individuals suspected selected...
Methionine synthase reductase, which is encoded by the methionine reductase (
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease called COVID-19. COVID-19 is primarily diagnosed using molecular techniques mainly real-time reverse transcriptase PCR. Reliable and accurate serologic assays for COVID-19, are an important tool surveillance epidemiologic studies. In this study, the IgG/IgM Rapid Test Cassette Prima detection of SARS-CoV-2 antibodies in blood, serum plasma samples collected from patients up to 48 days after symptom onset Saudi...
Different forms of human cancer show mutations for isocitrate dehydrogenases 1 and 2 (IDH1/2). Mutation these genes can cause aberrant methylation the genome CpG islands (CGIs), which leads to an increase suppressed oncogenes transcription or repression active tumor suppressor gene transcription. This study aimed identify prevalence IDH1/2 in acute leukemia patients. The cohort included 43 AML patients 30 childhood ALL patients, from whom DNA bone marrow samples were taken. alteration...
Tumor protein 53 (TP53) is a tumor-suppressor gene and plays an essential role in apoptosis, cell cycle arrest, genomic stability, DNA repair. Although it the most often mutated human cancer, has respectively low frequency hematological malignancy but significantly linked with complex karyotype, poor prognosis, chemotherapeutic response. Nevertheless, prevalence prognostic of TP53 mutations Saudi patients are not well reported. We, therefore, aim to assess malignancies Arabia.20 different...
The most effective way to control severity and mortality rate of the novel coronavirus disease (COVID-19) is through sensitive diagnostic approaches an appropriate treatment protocol. We aimed identify effect adding corticosteroid Tocilizumab a standard protocol in treating COVID-19 patients with chronic hematological lab biomarkers.This study was performed retrospectively on 68 who were treated by different therapeutic protocols. categorized into four groups: group represented patients'...
Background: The JAK2 V617F mutation’s discovery has largely facilitated the comprehension of myeloproliferative neoplasms’(MPNs) pathogenesis. In recent times, calreticulin (CALR) mutations have been detected in patients with JAK2V617F negative primary myelofibrosis (PMF), and essential thrombocythemia (ET).
 Methods: This study analyzed impact JAK 2 Exon 12 CALR common 65 MPN from Jeddah region. An allele-specific polymerase chain reaction (PCR) method was used to screen four on direct...