A5045177481- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Childhood Cancer Survivors' Quality of Life
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Folate and B Vitamins Research
- Nuclear Structure and Function
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- HIV-related health complications and treatments
- Innovative Teaching Methods
- Vitamin D Research Studies
- Blood groups and transfusion
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Experimental Learning in Engineering
- Parathyroid Disorders and Treatments
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- HIV Research and Treatment
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
King Abdulaziz University
2022-2025
Soliman Fakeeh Hospital
2022
University of Nottingham
2012-2019
An apurinic/apyrimidinic (AP) site is an obligatory cytotoxic intermediate in DNA Base Excision Repair (BER) that processed by human AP endonuclease 1 (APE1). APE1 essential for BER and emerging drug target cancer. We have isolated novel small molecule inhibitors of APE1. In this study, we investigated the ability to induce synthetic lethality (SL) a panel double-strand break (DSB) repair deficient proficient cells; i) Chinese hamster (CH) cells: BRCA2 (V-C8), ATM (V-E5), wild type (V79)...
Reduced Folate Carrier1 (RFC1) gene's metabolism is crucial for DNA synthesis, epigenetic mechanisms, and cellular methylation events. Nonetheless, RFC1 polymorphisms have drawn a lot of interest in current medical genetics studies. The objectives the study were to ascertain relationship between risk acute lymphoblastic leukemia Sudanese patients genetic variant (G 80A). Using Real-Time Polymerase Chain Reaction (RT-PCR) method, 150 Acute Lymphoblastic Leukemia (ALL) healthy control...
The flipped classroom is a teaching strategy used to enhance the engagement of students in learning process. Replacing didactic lectures with active strategies through sessions fosters independence and opportunity for engage different passive styles. Although many studies approach have been conducted medical students, few focused on effect other professional fields. aim this study was assess performance laboratory science hematology course their perception as an strategy. In addition,...
Chronic kidney disease, one of the most common diseases in world, is characterized by irreversible impairment kidney's metabolic, excretory, and endocrine functions. During end-stage renal patients require replacement therapy, such as hemodialysis (HD). Protein-energy wasting a health problem among HD patients. This study aims to assess nutritional status at two centers Jeddah, Saudi Arabia, determine its associated factors. A cross-sectional was conducted different dialysis Arabia; 211...
The Human Immunodeficiency Virus (HIV) is a highly morphic, retrovirus that rapidly evolves through mutation as well recombination. Because of the immunocompromised status in HIV patients, there often higher chance acquiring different secondary infections followed by liver cirrhosis, hepatitis B & C, and HIV-associated nephropathy. current study was conducted to see prevalence infections, hematological biochemical markers for renal associated diseases, detect envelope gene (GP41) newly...
Background: The outcome of acute myeloid leukemia (AML) is influenced by ethnicity, geographic variations, and the patient’s molecular profile. We aimed to explore mutation frequencies nucleophosmin 1 (NPM1) FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) or domain (TKD) with correlation cytogenetic profiles in patients AML. Methods Results: Bone marrow/whole blood samples from 33 AML were screened for NPM1/FLT3-ITD mutations fragments analysis using a GeneScan analyzer....
Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, epigenetic processes. It encoded by the MTRR gene, which garnered a lot of attention current medical genetics research. This study was conducted to association between (A66G) polymorphism risk developing acute lymphoblastic leukemia among Sudanese patients. Materials Methods. case-control 150 patients with (ALL) healthy participants as control group were enrolled....
α-thalassemia (α-thal) is a genetic disorder characterized by decreased synthesis of α-globin chains. A deletion mutation most often causes it in one or more No comprehensive characterization studies have been conducted on α-thal patients the Saudi population. Therefore, this research aims to identify spectrum mutations responsible for our region. Individuals with microcytic, hypochromic red blood cells and normal hemoglobin (Hb) A2 were enrolled. Sixty samples individuals suspected selected...
Methionine synthase reductase, which is encoded by the methionine reductase (
Context: Bone remodeling comprises balanced coupling of bone formation and resorption, low mineral density (BMD) demonstrates high rates resorption. Osteoporosis is a chronic asymptomatic disease with fragile bones impending risk fractures mediated by minor trauma. Whereas mineralization integrity are determined calcium vitamin D, specific serum markers such as alkaline phosphatase (ALP) osteocalcin (OC) play vital role in formation. Materials Methods: Serum calcium, ALP, OC levels were...
Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation is initiated by mutations in the JAK2 gene. This turn, a vital pathogenetic mechanism myeloproliferative neoplasms (MPNs). However, several factors affect pathogenesis MPNs other than gene mutations, such as downregulation cytokine signaling (SOCS) proteins, which are potent inhibitors JAK/STAT pathway. Therefore, we hypothesized that regulation SOCS protein system might be possible through activating...
The most effective way to control severity and mortality rate of the novel coronavirus disease (COVID-19) is through sensitive diagnostic approaches an appropriate treatment protocol. We aimed identify effect adding corticosteroid Tocilizumab a standard protocol in treating COVID-19 patients with chronic hematological lab biomarkers.This study was performed retrospectively on 68 who were treated by different therapeutic protocols. categorized into four groups: group represented patients'...
Abstract MCL1 and BCL2 are pro-survival molecules which inhibit the apoptosis of AML cells treated with cytotoxic chemotherapy. The nuclear chaperone NPM1 is most frequently mutated gene in AML. Using siRNA, we established that knockdown reduced expression both (P=0.034) (P=0.025) increased p53 (P=0.03) NPM1-mutant OCI-AML3 cells. These effects were not seen expressing wildtype NPM1. differentiating agent ATRA also (P=0.005) (P=0.0005). (3 days, 500 nM) cell number by 50% through growth...
Childhood (pediatric) obesity is becoming increasingly common at an alarming rate. Obese children are more likely to develop insulin resistance, relative insufficiency, and type 2 diabetes. Recent research suggests that mitochondrial dysfunction related to, may be predictive of, resistance among adult relatives of diabetes patients. Mitochondria produce ATP, which used create energy, especially in muscle tissue, they play a role glucose fat metabolism. Mitochondrial plays the development...
The most effective way to control severity and mortality rate of the novel coronavirus disease (COVID-19) is through sensitive diagnostic approaches an appropriate treatment protocol. We aimed identify effect adding corticosteroid Tocilizumab a standard protocol in treating COVID-19 patients with chronic hematological lab biomarkers.This study was performed retrospectively on 68 who were treated by different therapeutic protocols. categorized into four groups: group represented patients'...