A5089572167- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Vitamin D Research Studies
- Glycosylation and Glycoproteins Research
- Nutrition and Health in Aging
- Animal Nutrition and Physiology
- Nutritional Studies and Diet
- Iron Metabolism and Disorders
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Nigella sativa pharmacological applications
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Bioactive Compounds and Antitumor Agents
- Moringa oleifera research and applications
- Long-Term Effects of COVID-19
- Rabbits: Nutrition, Reproduction, Health
- Drug-Induced Hepatotoxicity and Protection
- Cancer therapeutics and mechanisms
- Essential Oils and Antimicrobial Activity
- Herbal Medicine Research Studies
- Immunotoxicology and immune responses
- Dengue and Mosquito Control Research
Umm al-Qura University
2018-2025
The present work describes the systematic development of paclitaxel and naringenin-loaded solid lipid nanoparticles (SLNs) for treatment glioblastoma multiforme (GBM). So far only temozolomide therapy is available GBM treatment, which fails by large amount due to poor brain permeability drug recurrent metastasis tumor. Thus, we investigated combination containing naringenin GBM, as these drugs have individually demonstrated significant potential management a wide variety carcinoma. A product...
Cervical cancer is the most important female genital that develops from cervix, a lower part of uterus. Houttuynia cordata ubiquitously present in Asian countries, and traditionally prescribed to treat infections oedema. Our study emphasizes on biological synthesis route for developing copper nanocomplex using (Hc-CuONPs) plant extract. The UV–visible spectroscopy Hc-CuONPs revealed maximum peak at 350 nm, which proved formation FT-IR absorption peaks existence different functional groups....
Abstract Mangiferin (MF) is a natural C-glucosylxantone compound that has many substantial curative potentials against numerous illnesses including cancers. The present study's goal to appraise the chemo preventive possessions of MF on azoxymethane (AOM)-mediated colonic aberrant crypt foci (ACF) in rats. Rats clustered into 5 groups, negative control (A), inoculated subcutaneously with normal saline twice and nourished 0.5% CMC; groups B-E injected 15 mg/kg followed by ingestion CMC (B,...
Abstract Background There are various factors that play a major role in influencing the overall health conditions of women diagnosed with breast cancer. The population Makkah region diverse, therefore it is significant to highlight possible determinants cancer this population. This case-control study assessed including socioeconomic factors, health-related characteristics, menstrual histories and breastfeeding among postmenopausal Saudi Arabia. Methods A total 432 female participants (214...
Chemoresistance to 5-fluorouracil (5-FU) is common during colorectal cancer (CRC) treatment. This study measured the chemotherapeutic effects of 5-FU, active vitamin D3 (VD3), and/or metformin single/dual/triple regimens as complementary/alternative therapies. Ninety male mice were divided into: negative and positive (PC) controls, VD3, Met, 5-FU/VD3, 5-FU/Met, VD3/Met, 5-FU/VD3/Met groups. Treatments lasted four weeks following CRC induction by azoxymethane. Similar also applied in SW480...
This study investigated the chemotherapeutic effects of 5-fluorouracil (5-FU), metformin (Met), and/or thymoquinone (TQ) single/dual/triple therapies in HT29, SW480 and SW620 colon cancer (CRC) cell lines. Cell cycle/apoptosis were measured by flow cytometry. The gene protein expression apoptosis (PCNA/survivin/BAX/Cytochrome-C/Caspase-3) cycle (CCND1/CCND3/p21/p27) molecules, PI3K/mTOR/HIF1α oncogenic pathway, glycolysis regulatory enzymes quantitative-PCR Western blot. Markers oxidative...
Abstract Although vitamin D (VD) and calcium (Ca) attenuate cadmium (Cd) metabolism, their combined antioxidant anti‐inflammatory actions against Cd toxicity have not been previously explored. Hence, this study measured the protective effects of VD ± Ca supplements hepatotoxicity. Forty adult male rats were distributed to: negative controls (NCs), positive (PCs), VD, Ca, 3 (VDC) groups. All groups, except NC, received CdCl 2 in drinking water (44 mg/L) for 4 weeks individually or...
The Biarum species (Kardeh) has been consumed as a traditional functional food and medicine for decades. current study investigates the phytochemistry, in-vitro in-vivo bioactivities of methanol extracts B. bovei.The Gas-chromatography mass spectrophotometer (GS/GS-MS) was used to analyze phytochemical profile bovei leaves corms. (BBE) were also investigated antioxidant, anticancer, acute toxicity (2000 mg/kg) activities.The chemical profiling BBE revealed mainly fatty acids, phytosterol,...
Abstract Background To investigate the anticancer effects of 5-Fluorouracil (5-FU), thymoquinone (TQ), and/or coenzyme Q10 (CQ10), alone and combined, in HT29, SW480, SW620 human colorectal cancer (CRC) cell lines. Methods Cell cycle progression apoptosis were assessed by flow cytometry. Gene protein expression molecules involved (BLC2, survivin, BAX, Cytochrome-C, Caspase-3), (CCND1, CCND3, p21, p27), PI3K/AKT/mTOR/HIF1α oncogenic pathway, glycolysis (LDHA, PDH, PDHK1) also analysed...
Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient with numerous biological activities extensively utilized in tumour chemotherapy. The present study investigates the chemo-preventive potentials of PN on azoxymethane-mediated colonic aberrant crypt foci rats.Sprague Dawley rats clustered into five groups, normal control (A) and cancer controls were subcutaneously injected saline 15 mg/kg azoxymethane, respectively, nourished 10% tween 20 fed 20; reference (C),...
Breast cancer is one of the leading causes death worldwide, it affects both men and women. In Saudi Arabia, breast has been most prevalent type in women, for past few years. Dietary habits cultural beliefs vary according to region, further studies are required demonstrate relationship between these dietary risk developing cancer. This study aimed discover preventive factors Mediterranean diet rates among postmenopausal women Makkah region Arabia.A case-control was conducted King Abdulla...
The objective of the current study was to ascertain effect using ginger powder or frankincense oil at different levels on production rate, biochemical properties blood, and immune response laying Japanese quail housed from 12 21 wk age. Three hundred sexually mature (200 females 100 males) were distributed among 5 groups age in a completely randomized design. Group 1: received basal diet not including additives acted as control group. Groups 2 3: with 250 500 mg ginger/kg feed, respectively....
Weight loss is a significant health problem among patients with head and neck cancer (HNC) that attributable primarily to the tumor or therapy. Critical weight (CWL) defined as unintentional of ≥5% weight. Therefore, this study's goal was investigate determine possible factors influencing CWL HNC who have received radiotherapy concurrent chemoradiotherapy (CCRT). We conducted retrospective analysis 175 CCRT either their primary, adjuvant, combined treatment at Oncology Center in King...
The exploration for effective in-feed additives is growing owing to the global climatic change trend alleviate negative effects of heat stress in laying hens. This research assessed potential using B-glucan (G) as an anti-heat agent Matrouh hens subjected early shock programs during period. Factorial design (3×3) was used, including three levels (control, at days and eight weeks age) β-glucan (0, 100 200 mg /kg diet). During first 12 egg production (EP), treatments were exposed challenge....
Breast cancer is a global health concern, with increasing disease burden and disparities in access to healthcare. Late diagnosis limited treatment options underserved areas contribute poor outcomes. In response this challenge, we developed novel family of 2-substituted-quinoxaline analogues, combining coumarin quinoxaline scaffolds known for their anticancer properties. Through versatile synthetic approach, designed, synthesized, characterized set 2-substituted derivatives. The...
Background. Timely detection of the progression highly contagious coronavirus disease (COVID-19) is utmost importance for management and intervention patients in intensive care (ICU). Aim. This study aims to better understand this new infection report changes various laboratory tests identified critically ill associated with poor prognosis among COVID-19 admitted ICU. Methods. was a retrospective that included 160 confirmed SARS-CoV-2-positive patients. Results. Elevated serum ferritin,...
Chronic kidney disease, one of the most common diseases in world, is characterized by irreversible impairment kidney's metabolic, excretory, and endocrine functions. During end-stage renal patients require replacement therapy, such as hemodialysis (HD). Protein-energy wasting a health problem among HD patients. This study aims to assess nutritional status at two centers Jeddah, Saudi Arabia, determine its associated factors. A cross-sectional was conducted different dialysis Arabia; 211...
Abstract Dengue fever is a major public health problem in Saudi Arabia. Unfortunately, preventive strategies are still deficient. It can progress to severe and lethal forms, available knowledge does not allow early prediction of which cases dengue (DF) will hemorrhagic (DHF). The aim this study was evaluate the host viral factors that could play role progression frame revised 2009 WHO classification. Data were compiled from Jeddah Fever Operation Room (DFOR) Maden Al-Fahd primary healthcare...