A5022597155- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Long-Term Effects of COVID-19
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- Bone health and osteoporosis research
- Sesquiterpenes and Asteraceae Studies
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- COVID-19 Impact on Reproduction
- Iron Metabolism and Disorders
- Cancer therapeutics and mechanisms
- Essential Oils and Antimicrobial Activity
- Tuberculosis Research and Epidemiology
- Blood donation and transfusion practices
- Pharmacogenetics and Drug Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Acute Myeloid Leukemia Research
- Phytochemistry and Bioactive Compounds
- Reproductive System and Pregnancy
King Abdulaziz University
2023-2024
King Abdul Aziz University Hospital
2022
Despite the advanced development in field of drug discovery and design, fighting infectious non-infectious diseases remains a major worldwide heath challenge due to limited activity currently used drugs. Nevertheless, recent years, approach designing nanoparticles for therapeutic applications has gained more interest promise future use. Thus, current study is focused on evaluation A. judaica extract chitosan loaded (CNPsLE) potential antimicrobial anticancer activities. The HPLC analysis...
There are millions of cancer cases worldwide every year, and breast is one the most prevalent diseases with highest mortality rate. The manual effort pathologists can be significantly reduced by computerized diagnostic systems, which improve accuracy reliability diagnosis. In this paper, we present four novel systems for diagnosis in different scenarios: binary versus multi-class classification magnification-specific (MS) magnification-independent (MI) classification. each proposed developed...
It is worth noting that laurel (Laurus nobilis L.) contains several pharmacologically and nutritionally active compounds may differ according to the pretreatment process. The current study designed clarify effect of moist heat on phenolic flavonoid constituents anti-Helicobacter pylori, antioxidant, antidiabetic, anti-Alzheimer's activities leaf extract (LLE). Unmoist-heated (UMH) moist-heated (MH) LLEs showed presence numerous constituents, although at different levels concentration. MH...
Abstract Despite the vital activity of many compounds, they lack that effectiveness due to their low solubility in water. Unfortunately, for this reason, rutin often leads tissue permeability and insufficient bioavailability, which has greatly limited its pharmacological utility. Therefore, present investigation is designed overcome problem by formulating rotin nanocrystals (RNCs) with studying some applications vitro silico. RNCs were created via ultrasonication approach showed a spherical...
Low bone mass, degeneration of tissue, and disruption microarchitecture are all symptoms the disease osteoporosis, which can decrease strength increase risk fractures. The main objective current study was to use a phospholipid-based phase separation in-situ gel (PPSG) in combination with an alendronate sodium nanoemulsion (ALS-NE) help prevent resorption rats. effect factors such as concentrations ALS aqueous solution, surfactant Plurol Oleique CC 497, Maisine oil on characteristics...
The present work studied the anticancer effects of four honey varieties on human cells by studying some physical parameters, hydrogen peroxide content, catalase, glucose oxidase, and microbial activities. Honey samples were (nigella sativa, moringa, sidr, pumpkin), which coded as NS, MO, SI, PU honey, respectively. tested bacterial isolates Staphylococcus aureus , Enterococcus faecalis used for Two types cells, breast, colon adenocarcinoma cell lines properties. SI showed lowest value...
Overexpression of the epidermal growth factor receptor (EGFR) has been shown to be a critical in tumor development and cancer progression. Although established EGFR inhibitors have effective treatment cancer, they are associated with several side effects. As result, there is an urgent need develop novel that can effectively target while causing no adverse Here, bioactive compounds Glycyrrhiza glabra screened against catalytic site. The LTS0058805, LTS0114552, LTS0128805, LTS0174203,...
Purpose: Genetic mutations are major factors in the diagnosis and prognosis of leukemia, it is difficult to assess these variants using single-gene analysis. Therefore, this study aimed develop a fast cost-effective method for genetic screening myeloid malignancies customized next-generation sequencing (NGS) panel. Patients Methods: A panel was designed investigated 15 acute leukemia patients. The included 11 genes that were most commonly mutated malignancies. This sequence complete genome...
The current study was designed to formulate ternary solid dispersions (TSDs) of dexibuprofen (Dex) by solvent evaporation augment the solubility and dissolution profile, in turn providing gastric protection effective anti-inflammatory activity. Initially, nine formulations (S1 S9) binary (BSDs) were developed. Formulation S1 comprising a 1:1 weight ratio Dex Syloid 244FP® chosen as optimum BSD formulation due its better profile. Afterward, 20 TSD developed using BSD. containing with 40%...
Cancer management is highly dependent on the immune status of patient. During COVID-19 pandemic, a large number people suffered from anxiety and depression, especially cancer patients. The effect depression breast (BC) prostate (PC) patients, during pandemic has been analyzed in this study. Levels proinflammatory cytokines (IFN-γ, TNF-α, IL-6) oxidative stress markers malondialdehyde (MDA) carbonyl content (CC) were estimated patients' serum samples. Serum antibodies against vitro hydroxyl...
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found crepe ginger and lettuce, medicinal herb with anticancer properties. Expression its downstream target genes (Myc TERT) wasdownregulated upon treatment costunolide Jurkat cells. A significant change telomere length cells not at 72...
The use of tyrosine kinase inhibitors (TKIs) and other targeted therapeutics plays a pivotal role in treatment management for individuals diagnosed with chronic myeloid leukemia (CML). However, some patients may experience fewer favorable outcomes resistance. Our work aims to whole transcriptome sequencing evaluate the variations gene expression patterns among CML based on their response TKI therapy.
The presence of COVID-19 antibodies in the maternal circulation is assumed to be protective for newborns against SARS-CoV-2 infection. We investigated whether crossed transplacental barrier and there was any difference hematological parameters neonates born mothers who recovered from during pregnancy. cross-sectional study conducted at Saidu Group Teaching Hospitals, located Swat, Khyber Pakhtunkhwa. After obtaining written informed consent, 115 healthy, unvaccinated mother-neonate dyads...
Background: β-thalassemia is an autosomal recessive hereditary hemoglobin production disorder characterized by abnormal synthesis. The efficient and safe therapies for transfusion-dependent (TDT) patients are desperately required to minimize the requirement blood transfusion. Objective: To establish safety efficacy of low-dose thalidomide in TDT patients. Methodology: retrospective cohort study was conducted Khyber Medical University, Peshawar Blood Diseases Clinic, investigate therapy...