A5028474885- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Bioactive natural compounds
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Diverse Scientific Research Studies
- Diabetes Treatment and Management
- vaccines and immunoinformatics approaches
- Quinazolinone synthesis and applications
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Animal Diversity and Health Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Neuroendocrine Tumor Research Advances
- Chemical Thermodynamics and Molecular Structure
- Mosquito-borne diseases and control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Jeddah
2022-2025
University of Haripur
2024
Mardin Artuklu University
2024
Jazan University
2024
Islamia College University
2024
Monash University
2024
King Abdulaziz University
2022
Abstract Background N ‐4 cytidine acetylation (ac4C) is an epitranscriptomics modification catalyzed by ‐acetyltransferase 10 (NAT10); important for cellular mRNA stability, rRNA biogenesis, cell proliferation and epithelial to mesenchymal transition (EMT). However, whether other crucial pathways are regulated NAT10‐dependent ac4C in cancer cells remains unclear. Therefore, this study, we explored the impact of NAT10 depletion using unbiased RNA‐seq. Methods High‐throughput sequencing...
Abstract Lung cancer is a disease with high mortality rate and it the number one cause of death globally. Approximately 12–14% non-small cell lung cancers are caused by mutations in KRAS G12C . The most prevalent mutants patients. was first considered undruggable. sotorasib adagrasib recently approved drugs that selectively target , offer new treatment approaches to enhance patient outcomes however drug resistance frequently arises. Drug development challenging, expensive, time-consuming...
The signal transducer and activator of transcription 3 (STAT3) plays a fundamental role in the growth regulation cellular life. Activation over-expression STAT3 have been implicated many cancers including solid blood tumors other diseases such as liver fibrosis rheumatoid arthritis. Therefore, inhibitors are be coming growing interesting area pharmacological research. Consequently, aim this study is to design novel STAT3-SH3 computationally for reduction fibrosis. Herein, we performed...
Cytochrome c is a critical protein in energy metabolism, and its structural adaptations to different temperatures play key role enabling species like the wild Bactrian camel (Camelus ferus) Arabian dromedarius) thrive their respective cold hot environments. This study investigates structural, thermodynamic, dynamic properties of cytochrome at temperatures. Thermal Titration Molecular Dynamics (TTMD) simulations, which involve analyzing behaviour across range temperatures, were carried out...
This study sought to ascertain if zinc nanoparticles (ZnNPs) could lessen the toxicity of azoxystrobin (AZ). naturally occurring methoxyacrylate is one most often used fungicides in agriculture male albino rats. Six sets 60 mature rats were randomly assigned: control (distilled water), Azoxystrobin formulation (AZOF), nano-formula (AZON), ZnNPs, AZOF + and AZON ZnNPs. Blood tissues obtained for further immunohistochemical, pathological, biochemical examination. The results showed that...
Venetoclax (ABT199) is a selective B-cell lymphoma 2 (BCL-2) inhibitor. The US FDA recently approved it to be used in combination with low-dose cytarabine or hypomethylating agents acute myeloid leukemia (AML) elderly patients non-eligible for chemotherapy. However, acquiring resistance venetoclax AML the primary cause of treatment failure. To understand molecular mechanisms inherent BCL-2 inhibitors, we generated venetoclax-resistant cell line model and assessed consequences this on its...
Cancer frequently develops resistance to the majority of chemotherapy treatments.This study aimed examine synergistic cytotoxic and antitumor effects SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), Doxorubicin (DOX), using in vitro experimentation.The precise combination CAN+DOX has been found greatly enhance doxorubicin (DOX) MCF-7 cells.Interestingly, it was shown that cancer cells exhibit an increased demand for glucose ATP order support their...
Purpose: Genetic mutations are major factors in the diagnosis and prognosis of leukemia, it is difficult to assess these variants using single-gene analysis. Therefore, this study aimed develop a fast cost-effective method for genetic screening myeloid malignancies customized next-generation sequencing (NGS) panel. Patients Methods: A panel was designed investigated 15 acute leukemia patients. The included 11 genes that were most commonly mutated malignancies. This sequence complete genome...
<title>Abstract</title> Diabetes, an alarming modern-day epidemic, imposes a substantial burden due to its rising incidence rate. in addition metabolic consequences, has emerged as contributor cognitive decline via number of underlying processes, including neuroinflammation. Among the critical processes linked diabetes, release pro-inflammatory cytokines received lot attention. The aim this current research study is determine potential 6-amino flavone agent for treating Alloxan-induced...
Aging is a complex process that not yet fully understood. Despite advancements in research, deeper understanding of the underlying biological mechanisms necessary to develop interventions promote healthy longevity. The aim this study was elucidate associated with aging and longevity elderly individuals. RNA sequencing (RNA-seq) data used obtained from Gene Expression Omnibus (GEO) database (accession number GSE104406), which collected Fluorescent Activated Cell Sorting (FACS) human bone...
Aging is a complex process that not yet fully understood. Despite advancements in research, deeper understanding of the underlying biological mechanisms necessary to develop interventions promote healthy longevity. The aim this study was elucidate associated with aging and longevity elderly individuals. RNA sequencing (RNA-seq) data used obtained from Gene Expression Omnibus (GEO) database (accession number GSE104406), which collected Fluorescent Activated Cell Sorting (FACS) human bone...
Dengue, caused by the dengue virus (DENV), a member of flavivirus family, continues to pose significant threat populations worldwide, despite advances in technology. Nearly half global population is at risk contracting disease, ranging from mild fever (DF) severe hemorrhagic (DHF) and Dengue Shock Syndrome (DSS). The precise mechanisms underlying progression DF DHF DSS remain unclear, presence various DENV serotypes exacerbates this situation. Urbanization climate change are expected affect...
The NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome is a well-known frequently cited regulator of caspase-1 activation. It plays significant role in several pathophysiological processes major the innate immune response. A growing amount scientific evidences for its aberrant activation various chronic inflammatory diseases attracts interest development new inhibitors. One successful strategies used to identify inhibitors peptide Compared small molecule inhibitors, show...