A5103171831- Computational Drug Discovery Methods
- Eicosanoids and Hypertension Pharmacology
- Phytochemicals and Antioxidant Activities
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Microbial Metabolites in Food Biotechnology
- Circular RNAs in diseases
- Food composition and properties
- Synthesis and biological activity
- Hepatitis C virus research
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- Alcohol Consumption and Health Effects
- Multicomponent Synthesis of Heterocycles
- Rheumatoid Arthritis Research and Therapies
- Plant-Microbe Interactions and Immunity
- Medicinal Plants and Neuroprotection
- Selenium in Biological Systems
- Forest ecology and management
- Coconut Research and Applications
- Biosimilars and Bioanalytical Methods
Sunway University
2024-2025
Monash University Malaysia
2023-2024
Saveetha University
2023-2024
Columbia University Irving Medical Center
2024
Monash University
2023-2024
Jeffrey Cheah Foundation
2024
Australian Regenerative Medicine Institute
2023-2024
Mahsa University
2021
As we navigate the modern era, intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, products have been foundational to health solutions, serving as primary healthcare choice for 80% 85% world's population. These herbal-based, nature-derived substances, significant across diverse geographies, necessitate renewed emphasis on enhancing their quality, efficacy, safety. In current century, advent...
Background: Ovarian cancer, colloquially termed the “silent killer” among gynecological malignancies, remains elusive due to its often-asymptomatic progression and diagnostic challenges. Central pathogenesis is overactive PI3K/Akt/mTOR signaling pathway, responsible for various cellular functions, from proliferation survival. Within this context, phytochemical compounds mangiferin (derived Mangifera indica ) curcumin (from Curcuma longa stand out their potential modulatory effects. However,...
Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of adult life, followed by gradual occurrence psychiatric disturbances, cognitive and motor dysfunction. The daily performances life quality HD patients have been severely interfered these clinical signs symptoms until last stage neuronal cell death. To best our knowledge, no treatment is available to completely mitigate progression HD. Mangiferin, naturally occurring potent glucoxilxanthone, mainly isolated...
According to the World Health Organization (WHO), cancer is second-highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite advances in diagnosis and treatment during last couple decades, it remains a serious concern due limitations currently available management strategies. Therefore, alternative strategies are highly required overcome these glitches. In addition, many etiological factors such as environmental genetic initiate activation Janus kinase...
Abstract A series of resveratrol surrogate molecules were designed, synthesized and biologically evaluated for inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE) along with anti‐oxidant activity as potential novel multifunctional agents against Alzheimer's disease (AD). Six compounds by reacting (E)‐4‐(3,5‐Dimethoxystyryl) aniline benzaldehyde some selected derivatives in the presence ethanol a few drops glacial acetic acid which followed general scheme involved formation...
The main objective of the present study was to improve solubility and dissolution rate felodipine (FLD), a drug that does not dissolve well in water, using self-nanoemulsifying delivery system (SNEDDS). Many analyses have been performed laboratory different oils, non-ionic surfactants, water-soluble co-solvents prepare FLD-loaded SNEDDS. It involves measurements viscosity, refractive index, droplet size. Solubility studies revealed best way load drugs, pseudo-ternary phase diagrams showed...
Alzheimer's disease (AD) is a major cause of disability and one the top causes mortality globally. AD remains public health challenge due to its prevalence, impact on patients caregivers, current lack cure. In recent years, polyphenols have garnered attention for their potential therapeutic effects AD. The objective study was establish network pharmacology between selected plant origin Insilico tools such as SwissADME, ProTox3.0, pkCSM, Swiss Target Prediction, DisGeNET, InterActiVenn, DAVID...
ABSTRACT Starch is a biomacromolecule comprising glucose units linked together and one of the most widely sourced biomacromolecules from plants because its easy availability versatility. However, high water solubility rapid degradation restrict application starch in some areas, such as drug delivery. This review describes an enzymatic debranching methodology for enhancing properties improving performance both delivery applications various industrial uses. Enzymatic debranching, with enzymes...
In an innovative approach to push the boundaries of antimicrobial and antioxidant strategies, we present synthesis characterization a novel terpolymer derived from N-Phenyl-p-phenylenediamine 2-aminopyrimidine with formaldehyde in presence dimethylformamide as reaction medium through polycondensation technique. Leveraging this ligand, introduce intriguing terpolymer-metal complex, created Ni (II) metal ion. our pursuit validate structure properties these substances, performed meticulous...
Background Brassica oleracea var. botrytis is an annual or biennial herbaceous vegetable plant in the Brassicaceae family notable for its edible blossom head. A lot of effort has gone into finding defense-associated proteins order to better understand how cauliflower and pathogens interact. Endophytes are organisms that live within host reproduce. bacteria fungi reside tissues can either help harm plant. Several species have aided molecular biologists biotechnologists various ways. Water...
Starch derived from plants plays an essential role in pharmaceuticals due to its components Amylose and Amylopectin, which form granules for drug delivery. Its biocompatibility cost-effectiveness make it indispensable pharmaceutical formulations, facilitating controlled release tablet breakdown. The effectiveness safety of formulations are often hindered by challenges such as low solubility stability. In order overcome these obstacles, current research is focused on modifying the properties...
Diabetes mellitus, notably type 2, is a rising global health challenge, prompting the need for effective management strategies. Common medications such as metformin, insulin, repaglinide and sitagliptin can induce side effects like gastrointestinal disturbances, hypoglycemia, weight gain specific organ risks. Plant-derived therapies Karanjin from Pongamia pinnata present promising alternatives due to their historical use, holistic benefits potentially fewer adverse effects. This study...