A5048590975- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Phytochemicals and Antioxidant Activities
- Diverse Scientific Research Studies
- Antioxidant Activity and Oxidative Stress
- Hibiscus Plant Research Studies
- Curcumin's Biomedical Applications
- Nuts composition and effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ethnobotanical and Medicinal Plants Studies
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Mangiferin and Mango Extracts
- Tannin, Tannase and Anticancer Activities
- Diet and metabolism studies
- Nanoparticles: synthesis and applications
- Plant Toxicity and Pharmacological Properties
- Nigella sativa pharmacological applications
- Food Science and Nutritional Studies
- Neonatal Health and Biochemistry
- Moringa oleifera research and applications
- Nutritional Studies and Diet
University of Calabar
2014-2025
Universiti Sains Malaysia
2012-2016
College of Medical Sciences
2014
Imo State University
2012
Polyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. We assessed antidiabetic and hence impact on biochemical indices toxicity by combination extracts from neem bitterleaf. Thirty rats, 25 diabetic 5 non-diabetic were used for study. The rats divided equally into five groups respectively treated: saline (diabetic control), bitterleaf combined, only, only chlorpropamide 24 day period....
As we navigate the modern era, intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, products have been foundational to health solutions, serving as primary healthcare choice for 80% 85% world's population. These herbal-based, nature-derived substances, significant across diverse geographies, necessitate renewed emphasis on enhancing their quality, efficacy, safety. In current century, advent...
As part of an investigation into the antidiabetic mechanism some indigenous medicinal plants, proximate, vitamins and mineral elements phytochemical compositions Azadirachta indica, Vernonia amygdalina Gongronema latifolium were quantitatively determined using standard methods compared. Of 3 plants G. had highest (p<0.05) crude protein fat contents but lowest in fibre composition, whereas A. indica with content composition. Fat ash V. . Also showed composition A, E niacin compared to...
This study evaluated the anti-inflammatory effect of Kaempferia galanga (KG) using an activity-guided approach. KG rhizomes were serially extracted with petroleum ether, chloroform, methanol and water. These extracts (2 g/kg each) tested for their ability to inhibit carrageenan-induced rat paw edema. The chloroform extract was found exert highest inhibition (42.9%) compared control (p < 0.001), hence it further fractionated by washing hexane, hexane-chloroform (1:1) chloroform. fraction...
To study the antidiabetic activity of Gynura procumbens (G. procumbens) used in traditional management diabetes Southern Asia. G. leaves were extracted sequentially with graded percentage ethanol water (95%, 75%, 50%, 25% and 0%), extracts tested for using acute (7 h), subcutaneous glucose tolerance test sub-chronic (14 d) non-diabetic streptozotocin-induced diabetic rats. The further subjected to phytochemical studies. In dose (1 g/kg), significantly lowered fasting blood (FBG) rats...
One vital therapeutic approach for the treatment of type 2 diabetes mellitus is use agents that can decrease postprandial hyperglycaemia by inhibiting carbohydrate digesting enzymes. The present study investigated effects bioassay-guided extract and fractions dried fruit pericarp Phaleria macrocarpa, a traditional anti-diabetic plant, on α-glucosidase α-amylase, in bid to understand their mechanism, as well possible attenuation action glucose increase.Methanol (ME), obtained successive...
Abstract Background Bisphenol-A (BPA), a chemical impregnated into plastic bottles which has been linked to obesity and its associated health problems, was used induce in this study. The cost reported limitations side effects of orthodox medications employed for weight management, have necessitated shift attention medicinal plants, given their comparative advantage the common belief amongst locals that plants are free from negative effects. One plant found application loss local population...
Background: The prevalent disease known as breast cancer has a significant impact on both men's and women's health quality of life. Aim: aim this study was to explore the potential roles Lecaniodiscus cupanioides (planch.) extract triterpenoid-derived gold nanoparticles (AuNPs) in therapy, specifically targeting MCF-7 cell lines. Methods: Gold were synthesized utilizing triterpenoid (ZJ-AuNPs) leaf from (LC-AuNPs). Fourier transform infrared spectroscopy (FTIR), Dynamic light scattering...
Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis insulin or impaired function. Throughout history, several civilizations have used traditional medicinal plants treat and control diabetes. This paper offers thorough review, date, antidiabetic natural compounds origin, specifically highlighting their reported modes mechanisms action therapeutic possibilities, with view fast-tracking possibility...
Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, Terminalia cattapa kernels were evaluated in vitro silico. RBC membrane stabilisation for characteristics, antioxidant activities by ABTS, DPPH, H2O2, nitric oxide scavenging assays, α-glucosidase α-amylase inhibitory assays conducted used to evaluate anti-diabetic activity. With an IC50 value 208 μg/mL , P. showed...
This study evaluated the impact of Vernonia amygdalina (VA) on transcription key enzymes involved in cellular modulation glucose streptozotocin-induced diabetic rats a bid to understand possible anti-diabetic mechanism VA. The chloroform fraction VA (200 mg/kg and 400 body weight) was administered SDRs for 7 14 days. Thereafter, expression (transcription) carbohydrate regulatory genes selected tissues - adipose, muscle liver. Also, weight blood changes were monitored. A 14-day administration...
An earlier anti-hyperglycemic study with serial crude extracts of Phaleria macrocarpa (PM) fruit indicated methanol extract (ME) as the most effective. In present investigation, was further fractionated to obtain chloroform (CF), ethyl acetate (EAF), n-butanol (NBF) and aqueous (AF) fractions, which were tested for antidiabetic activity. The NBF reduced blood glucose (p < 0.05) 15 min after administration, in an intraperitoneal tolerance test (IPGTT) similar metformin. Moreover, it lowered...
This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del. (VA) supplemented diet. VA leaf powder fed at 5% and 15% diet-induced obese rats for 4 weeks its compared with orlistat (5.14 mg/kg p.o.), an drug. Food intake, body organ weights, total fat, some lipid components amino transaminase activities in serum, hepatocytes brain; as well serum glucose, were measured during or end study. Result showed respective decrease 12.78% 38.51% weight gain, against...
Fruits of Phaleria macrocarpa are used in the traditional health system Indonesians and lower course Malaysia, as effective remedy management for diabetes mellitus. This study therefore investigated hypoglycemic anti-hyperglycemic effects P. extracts normal diabetic rats, respectively. The fruits were sequentially extracted petroleum ether, methanol water to obtained 3 extracts. Blood glucose response acute dose (1g/kg b.w.) intra-peritoneal tolerance test (IPGTT) was performed rats a 12-day...
The protective effect of ethanolic leaf-extract an anti-diabetic plant, Vernonia amygdalina Del. on hepatic cell architecture and some biochemical indices liver function has been studied in alloxanized Wistar rats. Twenty-one rats (120-160g) were included the study assigned to 3 groups 7 each. Groups 1 2, normal diabetic controls received placebo treatment, whereas group experimentally administered plant extract (400mg/kg body weight) by gastric intubation for 14 days. Serum aminotransferase...
Azadirachta indica A. Juss. (Meliaceaes) leaves have been used traditionally to treat swelling and rheumatism in Indian cultures.To fractionate leaf extracts using bioactivity guided manner for identification of the active anti-inflammatory principles.Polarity-gradient sequential (petroleum ether, chloroform, methanol, water) were screened their potential carrageenan-induced rat paw edema model (1 g/kg). The chloroform extract was sequentially fractionated obtain n-hexane (F-1),...