A5059014202- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Hemoglobinopathies and Related Disorders
- Drug Transport and Resistance Mechanisms
- Iron Metabolism and Disorders
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Electrochemical sensors and biosensors
- Glioma Diagnosis and Treatment
- Autism Spectrum Disorder Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Saffron Plant Research Studies
- Cerebral Venous Sinus Thrombosis
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Nigella sativa pharmacological applications
- Biochemical Analysis and Sensing Techniques
- Lanthanide and Transition Metal Complexes
- Chemotherapy-induced organ toxicity mitigation
King Saud University
2019-2024
Security Forces Hospital
2019-2023
Nova Southeastern University
2017-2022
Taif University
2022
University of Tabuk
2022
Imam Mohammad ibn Saud Islamic University
2021
King Abdulaziz Medical City
2020
Pharmac
2020
National Guard Health Affairs
2020
Southeastern University
2017
As we navigate the modern era, intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, products have been foundational to health solutions, serving as primary healthcare choice for 80% 85% world's population. These herbal-based, nature-derived substances, significant across diverse geographies, necessitate renewed emphasis on enhancing their quality, efficacy, safety. In current century, advent...
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that leads to demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid myeloid origin play a significant role initiation amplification inflammation MS. STAT3 signaling plays pivotal both immune cells, such as neutrophils CD4+ T through regulation their potential. Dysregulation cell compartments has been reported In this report, we attempted investigate effect small molecular inhibitor STAT3,...
Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, inflammatory response, apoptotic events, and irritation which may develop into cancer. However, medications commonly used GU treatment cannot normalize mucosa, while causing several adverse effects. Proanthocyanidins (PAs) are dietary flavonoids numerous biological pharmacological activities. In current investigation, we studied potential anti-ulcerative activity of PAs against acidified ethanol...
In the present work, an attempt was undertaken to improve oral bioavailability and anticancer activity of abiraterone acetate. Solid lipid nanoparticles (SLNs) were developed using quality by design (QbD) principles evaluated through in vitro, ex vivo, vivo studies. suitability equilibrium solubility study, while surfactant cosurfactant screened based on ability form microemulsion with selected lipid. SLNs prepared emulsion/solvent evaporation method glyceryl monostearate, Tween 80,...
Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington's disease (HD). Methods: We conducted literature review the pathophysiology HD limitations currently available medications. also reviewed potential therapeutic benefits engeletin, flavanol glycoside, through Keap1/nrf2 pathway. then proposed across blood-brain barrier (BBB) bioavailability. Results: is an autosomal dominant...
Sepsis affects millions of people worldwide and is associated with multiorgan dysfunction that a major cause increased morbidity mortality. several morbidities, such as lung, liver, central nervous system (CNS) dysfunction. Sepsis-associated CNS usually leads to mental problems including depression. IL-17A one the crucial cytokines expressed secreted by Th17 cells. cells are reported be involved in pathogenesis depression anxiety humans animals. One protein tyrosine kinases plays key role...
The plant Trigonella foenum-graecum, well-known as fenugreek, has been shown to control type-2 diabetes, the level of cholesterol, inflammation wounds, disorders related gastrointestinal tracts, and cancer well. present study aimed evaluate anti-cancer potential methanolic fenugreek seed extract (FSE) its possible molecular mechanism action in breast cells.The anticancer FSE was evaluated MCF-7 SK-BR3 cells through various cellular assays after selecting IC10, IC25, IC35, IC50 doses by cell...
Dasatinib is an effective treatment for chronic myeloid leukemia. However, cases of idiosyncratic hepatotoxicity were reported. This study was conducted to investigate the chemopreventive effects hydroxychloroquine against dasatinib-induced hepatotoxicity. Balb/c mice randomly assigned into four groups; vehicle control (5% DMSO, i.p., n = 6), dasatinib (50 mg/kg; (10 mg/kg, and + mg/kg 50 6). Treatments given once every 2 days 14 days. Serum histopathological assessments liver architecture...
Non-small cell lung carcinoma is a challenging disease worldwide. This study aims to determine whether combining erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, with cabozantinib, mesenchymal-epithelial transition (c-Met) would have augmented therapeutic benefit on A549 cells. The combination of erlotinib and cabozantinib (5 µM) inhibited viability compared each monotherapy at ≥ 10 µM as confirmed by the MTT assay. Combination therapy also has more potent inhibition cellular...
Background Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% pregnant females, and 30% non-pregnant females 15 50 years) worldwide according the WHO. Environmental genetic factors play crucial role development IDA; testing revealed association number polymorphisms with iron status serum ferritin. Aim The current study aims reveal TMPRSS6 rs141312 BMP2 rs235756 Saudi Arabia. Methods...